Globo sphingolipid metabolism (Homo sapiens)

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Denise Slenter, Alexander Pico, Egon Willighagen, Kristina Hanspers, et al.

Description

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Ontology Terms

Pathway Ontology : signaling pathway pertinent to immunity

Bibliography

Hannun YA, Obeid LM; ''Sphingolipids and their metabolism in physiology and disease.''; Nat Rev Mol Cell Biol, 2018 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
117733	view	12:37, 22 May 2021	Eweitz	Modified title
115205	view	20:53, 4 February 2021	Khanspers	cleaned up layout
110180	view	14:18, 23 April 2020	Egonw	Ontology Term : 'globoside metabolic pathway' added !
108809	view	15:53, 30 January 2020	DeSl	Removed last modified item.
108808	view	15:51, 30 January 2020	DeSl	Reconnected last proteins.
108806	view	15:43, 30 January 2020	DeSl	Connected proteins in correct manner
108805	view	15:40, 30 January 2020	DeSl	Added lit. ref.
108803	view	15:34, 30 January 2020	DeSl	Modified description
106691	view	13:00, 17 September 2019	MaintBot	HMDB identifier normalization
97521	view	13:54, 24 May 2018	DeSl	Changed name for GeneNode.
96291	view	15:47, 7 March 2018	Fehrhart	fixed connections
94290	view	13:04, 31 August 2017	DeSl	I connected the nodes where I could... don't know what to do with the rest of this PW...
87539	view	02:06, 25 July 2016	AlexanderPico	Ontology Term : 'classic metabolic pathway' added !
87538	view	02:06, 25 July 2016	AlexanderPico	Ontology Term : 'sphingolipid metabolic pathway' added !
83526	view	16:40, 20 November 2015	Jmelius	Correct outdated id
71392	view	18:43, 17 October 2013	MaintBot	Automated update of data sources
69411	view	19:01, 8 July 2013	Egonw	Replaced an outdated HMDB identifier with the 3.5 one.
63195	view	20:52, 8 May 2013	MaintBot	Updating gpml version
62368	view	00:18, 28 April 2013	AlexanderPico	Removed phantom object
62367	view	00:17, 28 April 2013	AlexanderPico	Fixed annotations
59222	view	20:14, 22 February 2013	MaintBot	Updated Ensembl and UniProt data source
41234	view	23:46, 1 March 2011	MaintBot	Removed redundant pathway information and comments
34582	view	22:21, 21 December 2009	Khanspers	Modified categories
33069	view	20:53, 11 October 2009	MaintBot	Specify description
33068	view	20:52, 11 October 2009	MaintBot	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
2.4.1.-	GeneProduct	2.4.1.- (Enzyme Nomenclature)	2.4.1.-
A3GALT2	GeneProduct	ENSG00000128274 (Ensembl)
A3GALT2	GeneProduct	ENSG00000184389 (Ensembl)
A4GALT	GeneProduct	ENSG00000128274 (Ensembl)	2.4.1.228
ABO	GeneProduct	ENSG00000175164 (Ensembl)
B3GALT5	GeneProduct	ENSG00000183778 (Ensembl)
FUT1	GeneProduct	ENSG00000174951 (Ensembl)
FUT2	GeneProduct	ENSG00000176920 (Ensembl)	2.4.1.69
FUT9	GeneProduct	ENSG00000172461 (Ensembl)	2.4.1.152
Forssman Antigen Synthase	GeneProduct	Q8N5D6 (Uniprot-TrEMBL)	2.4.1.88
GALNT2	GeneProduct	ENSG00000143641 (Ensembl)
GCNT1	GeneProduct	ENSG00000187210 (Ensembl)
Gb3	Metabolite	HMDB04879 (HMDB)
Gb4	Metabolite	HMDB04960 (HMDB)
Globo H	Metabolite	HMDB04963 (HMDB)
Globoside Synthase	Protein	O75752 (Uniprot-TrEMBL)
LacCer	Metabolite	HMDB06750 (HMDB)
SSEA-3	Metabolite	HMDB04962 (HMDB)
SSEA-4	Metabolite
ST3GAL1	GeneProduct	ENSG00000008513 (Ensembl)
ST3GAL2	GeneProduct	ENSG00000157350 (Ensembl)	2.4.99.4
ST6GAL1	GeneProduct	ENSG00000073849 (Ensembl)
ST6GAL2	GeneProduct	ENSG00000144057 (Ensembl)
ST6GALNAC1	GeneProduct	ENSG00000070526 (Ensembl)
ST6GALNAC2	GeneProduct	ENSG00000070731 (Ensembl)
ST6GALNAC3	GeneProduct	ENSG00000184005 (Ensembl)
ST6GALNAC4	GeneProduct	ENSG00000136840 (Ensembl)
ST6GALNAC5	GeneProduct	ENSG00000117069 (Ensembl)
ST6GALNAC6	GeneProduct	ENSG00000160408 (Ensembl)
ST8SIA1	GeneProduct	ENSG00000111728 (Ensembl)	2.4.99.8