Physico-chemical features and toxicity-associated pathways (Homo sapiens)

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Genes that were found to be up regulated have been marked red and genes that were found to be down regulated have been marked blue. These 3 pathways demonstrate close links between pathways associated with chemical hits and pathways associated with toxicity. The pathways associated with chemical hits (Wnt signaling, long-term depression, and ErbB signaling pathways) and the pathways associated with toxicity (focal adhesion, ALS, and pancreatic Cancer respectively) have been shown to have possible links through shared genes between the two pathways. The mechanisms of action presented by these links were only implied by the toxicity pathways.