Interleukin-1 induced activation of NF-kB (Homo sapiens)
From WikiPathways
Description
Interleukin-1 Induced activation of NF-kB through the phosphorylated TRAF6/Ajuba/PKCz/SQST1 complex. The pathway is defined by multiple binding steps to the TRAF6/Ajuba/PKCz/SQST1 complex. The small arrows constitute a earlier binding. After binding occurs the complex is phosphorylated and activates NF-kB. This pathway is based on figure 6 from Li et al.
Quality Tags
Ontology Terms
Saving...Bibliography
- Li F, Thiele I, Jamshidi N, Palsson BØ; ''Identification of potential pathway mediation targets in Toll-like receptor signaling.''; PLoS Comput Biol, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ADP | Metabolite | HMDB01341 (HMDB)  | |
| AJUBA | GeneProduct | ENSG00000129474 (Ensembl) | |
| ATP | Metabolite | HMDB00538 (HMDB) | |
| IL-1 | GeneProduct | ENSG00000115008 (Ensembl) | |
| IRAK1 | GeneProduct | ENSG00000184216 (Ensembl) | |
| NF-KB | GeneProduct | P19838 (Uniprot-SwissProt) | |
| PKCZ | GeneProduct | ENSG00000067606 (Ensembl) | |
| Phosphate | Metabolite | HMDB01429 (HMDB) | |
| SQSTM1 | GeneProduct | ENSG00000161011 (Ensembl) | |
| TIFA | GeneProduct | ENSG00000145365 (Ensembl) | |
| TRAF6 | GeneProduct | ENSG00000175104 (Ensembl) | |
| UBC13 | GeneProduct | ENSG00000177889 (Ensembl) | |
| UEV1A | GeneProduct | ENSG00000244687 (Ensembl) | |
| Ubiquitin | GeneProduct | P0CG48 (Uniprot-TrEMBL) |
Annotated Interactions
No annotated interactions
