Benzene metabolism (Homo sapiens)

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1Nonenzymatic rearrangementHydroquinoneCatecholOxepineCYP2E1CYP2E1PhenolNQO1Dihydrodiol dehydrogenaseNQO1p-benzoquinoneBenzene diol epoxideEpoxide hydrolaseMPOGlutathione S-transferase1,2-BenzoquinoneBenzene oxideBenzeneBenzene dihydrodiolS-Phenylmercapturic acidMPO


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Rappaport SM, Kim S, Lan Q, Vermeulen R, Waidyanatha S, Zhang L, Li G, Yin S, Hayes RB, Rothman N, Smith MT; ''Evidence that humans metabolize benzene via two pathways.''; Environ Health Perspect, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140984view11:34, 31 October 2025EweitzClear cached dimensions
140983view11:32, 31 October 2025EweitzEconomize layout
106161view12:05, 16 August 2019MaintBotHMDB identifier normalization
97681view13:56, 1 June 2018AMTanOntology Term : 'hepatocyte' added !
94538view07:01, 21 September 2017EgonwRemoved a redundant newline.
89359view13:30, 7 September 2016Riannefijtenadded identifier vor microsomal epoxide hydrolase
89346view09:52, 6 September 2016RiannefijtenModified description
89345view09:52, 6 September 2016RiannefijtenModified description
89344view04:35, 6 September 2016EgonwUsed mim-conversion and annotated the catalysis with a mim approach too.
89339view03:16, 5 September 2016EgonwOntology Term : 'classic metabolic pathway' added !
89338view03:16, 5 September 2016EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
89313view13:15, 1 September 2016RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-BenzoquinoneMetaboliteHMDB12133 (HMDB)
Benzene dihydrodiolMetabolite418 (PubChem-compound)
Benzene diol epoxideMetabolite
Benzene oxideMetabolite104944 (PubChem-compound)
BenzeneMetaboliteHMDB01505 (HMDB)
CYP2E1GeneProductENSG00000130649 (Ensembl)
CatecholMetabolite289 (PubChem-compound)
Dihydrodiol dehydrogenaseProtein27294 (Entrez Gene)
Epoxide hydrolaseProtein
Glutathione S-transferaseGeneProduct2944 (Entrez Gene)
HydroquinoneMetaboliteHMDB02434 (HMDB)
MPOGeneProduct4353 (Entrez Gene)
NQO1GeneProductENSG00000181019 (Ensembl)
OxepineMetabolite6451477 (PubChem-compound)
PhenolMetaboliteHMDB00228 (HMDB)
S-Phenylmercapturic acidMetaboliteHMDB42011 (HMDB)
p-benzoquinone Metabolite4650 (PubChem-compound)

Annotated Interactions

No annotated interactions

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