Benzene metabolism (Homo sapiens)

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1NonenzymaticrearrangementCYP2E1Benzene1,2-BenzoquinoneEpoxide hydrolaseCatecholHydroquinoneMPOCYP2E1p-benzoquinoneGlutathione S-transferaseDihydrodioldehydrogenaseBenzene diol epoxideBenzene dihydrodiolPhenolNQO1NQO1OxepineBenzene oxideS-Phenylmercapturic acidMPO


Description

This pathway describes the metabolism of benzene. It is metabolised in the liver and forms several metabolites that can be toxic to the human body. Some of the metabolites are very volatile and can be found in blood and exhaled breath.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Rappaport SM, Kim S, Lan Q, Vermeulen R, Waidyanatha S, Zhang L, Li G, Yin S, Hayes RB, Rothman N, Smith MT; ''Evidence that humans metabolize benzene via two pathways.''; Environ Health Perspect, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106161view12:05, 16 August 2019MaintBotHMDB identifier normalization
97681view13:56, 1 June 2018AMTanOntology Term : 'hepatocyte' added !
94538view07:01, 21 September 2017EgonwRemoved a redundant newline.
89359view13:30, 7 September 2016Riannefijtenadded identifier vor microsomal epoxide hydrolase
89346view09:52, 6 September 2016RiannefijtenModified description
89345view09:52, 6 September 2016RiannefijtenModified description
89344view04:35, 6 September 2016EgonwUsed mim-conversion and annotated the catalysis with a mim approach too.
89339view03:16, 5 September 2016EgonwOntology Term : 'classic metabolic pathway' added !
89338view03:16, 5 September 2016EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
89313view13:15, 1 September 2016RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-BenzoquinoneMetaboliteHMDB12133 (HMDB)
Benzene dihydrodiolMetabolite418 (PubChem-compound)
Benzene diol epoxideMetabolite
Benzene oxideMetabolite104944 (PubChem-compound)
BenzeneMetaboliteHMDB01505 (HMDB)
CYP2E1GeneProductENSG00000130649 (Ensembl)
CatecholMetabolite289 (PubChem-compound)
Dihydrodiol dehydrogenaseProtein27294 (Entrez Gene)
Epoxide hydrolaseProtein
Glutathione S-transferaseGeneProduct2944 (Entrez Gene)
HydroquinoneMetaboliteHMDB02434 (HMDB)
MPOGeneProduct4353 (Entrez Gene)
NQO1GeneProductENSG00000181019 (Ensembl)
OxepineMetabolite6451477 (PubChem-compound)
PhenolMetaboliteHMDB00228 (HMDB)
S-Phenylmercapturic acidMetaboliteHMDB42011 (HMDB)
p-benzoquinone Metabolite4650 (PubChem-compound)

Annotated Interactions

No annotated interactions

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