T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection (Homo sapiens)

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Revision as of 23:35, 29 September 2016 by Khanspers (Talk | contribs)
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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none DNASuperantigen (SEB)Proliferation, Differentiation, Immune responseDagSHP1PIP3PLC-1yIKbNF-KbPKC-thetaRafTNF-alphaIL2IL4IL10IFN-gammaIL5GM-CSFCdk4Grb2NckNIKCD45RASGRP1SLP76CblCOTAktJunFosCalcineurinGADSIP3Dlgh1TCR-alphaCD3TCR-betaIKK-gammaIKK-betaIKK-alphaAP1CalmodulinERKMEK2MEK1Cd8Cd4LATMalt1CARMA1Bcl10Pdk1FynPI3KLckCtla4MKK7p38CD40LJNK2ItkPD1PakGsk3bSOSCd28CalciumTAK1ICOSNFATZap70Grb2RASCalciumCalmodulinName: The Reaction of the immune system when infected with Staphylococcal Enterotoxin BOrganism: Homo sapiens


Description

This pathway is based on Figure 4 of “A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway”(see bibliography). The pathway displays the T-cell receptors of homo sapiens when infected with the disease Staphylococcus Enterotoxin B. The binding of a superantigen to the T cell receptor results in a protein signaling pathway resulting in cell proliferation, differentiation, and immune response due to altered DNA expression.

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Tomar N, De RK; ''A model of an integrated immune system pathway in Homo sapiens and its interaction with superantigen producing expression regulatory pathway in Staphylococcus aureus: comparing behavior of pathogen perturbed and unperturbed pathway.''; PLoS One, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127932
Approved
view23:07, 17 January 2024Khanspersimproved layout
121717view15:08, 26 February 2022EweitzFix IDs, use gene symbols
121707view04:41, 26 February 2022EweitzUse gene symbol
120420view13:10, 30 November 2021EweitzFix incorrectly-cased symbols, and update some others to Ensembl preferred label
116778view09:50, 14 May 2021EweitzModified title
116777view09:49, 14 May 2021EweitzModified title
106753view13:23, 17 September 2019MaintBotHMDB identifier normalization
97627view10:08, 31 May 2018AMTanOntology Term : 'T cell' added !
90702view11:53, 13 December 2016EveloModified title
90701view11:53, 13 December 2016EveloModified title
90029view19:38, 8 October 2016AlexanderPicoModified description
89739view23:37, 29 September 2016KhanspersModified title
89738view23:36, 29 September 2016KhanspersModified description
89737view23:35, 29 September 2016Khansperscorrected label
89641view23:03, 22 September 2016Khanspersminor layout
89607view09:09, 20 September 2016EgonwReverted a premature change I made. Clearly human now.
88763view19:06, 14 August 2016AAR&CoModified description
88762view18:59, 14 August 2016AAR&CoAdded Data Nodes
88759view18:51, 14 August 2016AAR&CoEdited Annotations
88758view18:47, 14 August 2016AAR&CoModified Datanodes
88752view18:38, 14 August 2016AAR&CoPeriodical save, work in progress
88747view18:28, 14 August 2016AAR&CoPeriodical save, work in progress
88742view18:18, 14 August 2016AAR&CoPeriodical save, work in progress
88549view01:34, 11 August 2016AAR&CoPeriodical save, work in progress
88537view00:54, 11 August 2016AAR&CoPeriodical save, work in progress
88533view00:44, 11 August 2016AAR&CoPeriodical save, work in progress
88529view00:24, 11 August 2016AAR&CoPeriodical save, work in progress
88523view00:07, 11 August 2016AAR&CoModified Datanodes
88508view23:18, 10 August 2016AAR&CoPeriodical save, work in progress
88503view23:00, 10 August 2016AAR&CoModified Datanode
88498view22:57, 10 August 2016AAR&CoPeriodical save, work in progress
88496view22:53, 10 August 2016AAR&CoModified Datanodes
88489view22:33, 10 August 2016AAR&CoPeriodical save, work in progress
88483view22:23, 10 August 2016AAR&CoPeriodical save, work in progress
88480view22:12, 10 August 2016AAR&CoPeriodical save, work in progress
88193view23:42, 30 July 2016AAR&CoModified Datanode
88192view23:40, 30 July 2016AAR&CoModified Datanode Gene ID
88189view23:34, 30 July 2016AAR&CoModified Database
88174view14:34, 29 July 2016MkutmonOntology Term : 'infectious disease pathway' added !
88167view08:41, 29 July 2016Mkutmonunconnected lines
87424view11:33, 22 July 2016MkutmonOntology Term : 'immune response pathway' added !
87344view17:39, 21 July 2016AAR&CoModified title
87343view17:39, 21 July 2016AAR&CoAdded Datanodes
87342view17:27, 21 July 2016AAR&CoModified description
87341view17:26, 21 July 2016AAR&CoOntology Term : 'toxic shock syndrome' added !
87340view17:22, 21 July 2016AAR&CoAdded Datanodes
87339view17:21, 21 July 2016AAR&CoPeriodical save, work in progress
87338view17:14, 21 July 2016AAR&CoAdded Data Nodes
87337view17:10, 21 July 2016AAR&CoPeriodical save, work in progress
87336view17:05, 21 July 2016AAR&CoAdded Datanodes

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AP1GeneProductENSG00000177606 (Ensembl)
AktGeneProductENSG00000142208 (Ensembl)
Bcl10GeneProductENSG00000142867 (Ensembl)
CARMA1GeneProductENSG00000198286 (Ensembl)
CD3GeneProductENSG00000167286 (Ensembl) CD3 Not Specified
CD40LGeneProductENSG00000102245 (Ensembl)
CD45GeneProductENSG00000081237 (Ensembl)
COTGeneProductENSG00000107968 (Ensembl)
CalcineurinGeneProductENSG00000187446 (Ensembl)
CalciumMetaboliteHMDB00464 (HMDB)
CalmodulinProteinENSG00000198668 (Ensembl)
CalmodulinProteinP62204 (Uniprot-TrEMBL)
CblGeneProductENSG00000110395 (Ensembl)
Cd28GeneProductENSG00000178562 (Ensembl)
Cd4GeneProductENSG00000010610 (Ensembl)
Cd8GeneProductENSG00000153563 (Ensembl) CD8 Not Specified
Cdk4GeneProductENSG00000135446 (Ensembl)
Ctla4GeneProductENSG00000163599 (Ensembl)
DagGeneProductQ62165 (Uniprot-TrEMBL) Dag Not Specified
Dlgh1GeneProductENSG00000075711 (Ensembl)
ERKGeneProductENSG00000102882 (Ensembl)
FosGeneProductENSG00000170345 (Ensembl)
FynGeneProductENSG00000010810 (Ensembl)
GADSGeneProductENSG00000100351 (Ensembl)
GM-CSFGeneProductENSG00000164400 (Ensembl)
GRP1GeneProductO08967 (Uniprot-TrEMBL)
Grb2GeneProductENSG00000177885 (Ensembl)
Gsk3bGeneProductENSG00000082701 (Ensembl)
ICOSGeneProductENSG00000163600 (Ensembl)
IFN-gammaGeneProductENSG00000111537 (Ensembl)
IKK-alphaGeneProductENSG00000213341 (Ensembl)
IKK-betaGeneProductENSG00000104365 (Ensembl)
IKK-gammaGeneProductENSG00000269335 (Ensembl)
IKbGeneProductENSG00000100906 (Ensembl) Ikb Not Specified
IL10GeneProductENSG00000136634 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IP3Metabolite439456 (PubChem-compound)
ItkGeneProductENSG00000113263 (Ensembl)
JNK2GeneProductENSG00000050748 (Ensembl)
JunGeneProductENSG00000177606 (Ensembl)
LATGeneProductENSG00000213658 (Ensembl)
LckGeneProductENSG00000182866 (Ensembl)
MEK1GeneProductENSG00000169032 (Ensembl)
MEK2GeneProductENSG00000126934 (Ensembl)
MKK7GeneProductENSG00000076984 (Ensembl)
Malt1GeneProductENSG00000172175 (Ensembl)
NF-KbGeneProductENSG00000109320 (Ensembl)
NFATGeneProductENSG00000101096 (Ensembl) General Name for Transcription Factors
NIKGeneProductENSG00000006062 (Ensembl)
NckGeneProductENSG00000158092 (Ensembl)
PD1GeneProductENSG00000188389 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PIP3MetaboliteHMDB10147 (HMDB)
PKC-thetaGeneProductENSG00000065675 (Ensembl)
PLC-1yGeneProductENSG00000124181 (Ensembl)
PakGeneProductENSG00000149269 (Ensembl)
Pdk1GeneProductENSG00000152256 (Ensembl)
RASGeneProductENSG00000126458 (Ensembl)
RafGeneProductENSG00000132155 (Ensembl)
SHP1GeneProductENSG00000111679 (Ensembl)
SLP76GeneProductENSG00000043462 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
TAK1GeneProductENSG00000135341 (Ensembl)
TCR-alphaGeneProductENSG00000211879 (Ensembl)
TCR-betaGeneProductENSG00000281958 (Ensembl)
TNF-alphaGeneProductENSG00000232810 (Ensembl)
Zap70GeneProductENSG00000115085 (Ensembl)
p38GeneProductENSG00000100591 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3863"
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