mir-124 predicted interactions with cell cycle and differentiation (Homo sapiens)
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Description
Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery.
A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.
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Ontology Terms
Saving...Bibliography
- Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, Purinton S, Wang Y, Ivan C, Kim HS, Borkowski RJ, Khan S, Rodriguez-Aguayo C, Lopez-Berestein G, Lea J, Gazdar A, Baggerly KA, Sood AK, White MA; ''A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.''; Mol Syst Biol, 2015 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AMPK | GeneProduct | ENSG00000132356 (Ensembl)  | |
| KLB1 | GeneProduct | ENSG00000118046 (Ensembl) | |
| PTBP | GeneProduct | ENSG00000011304 (Ensembl) | |
| SCP1 | GeneProduct | ENSG00000144579 (Ensembl) | |
| SIX4 | GeneProduct | ENSG00000100625 (Ensembl) | |
| STRADB | GeneProduct | ENSG00000082146 (Ensembl) | |
| hsa-miR-124a | Rna | MIMAT0000422 (miRBase mature sequence) |
Annotated Interactions
No annotated interactions
