DNA replication (Homo sapiens)

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p70Cdc62. Activation of the pre-replicative complexCdt1RFC140Mcm 4,6,7 trimer forms andassociates with the replication fork5. Leading/lagging strand synthesisOrc4Mcm4Mcm3Mcm2Orc complexDNAPolymerase AMcm6UbiquitinUbiquitinated Orc1Orc5RNA PrimerDNA polymerase alpha:primase: origin complexUbiquitinated Cdc6OriginOrc3RFC40Mcm3RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc5Pre-replicative complexOrc complexMcm2RFC37p180Phosphorylated Cdc6UbiquitinOrc4Mcm6RFC Heteropentamer:RNA primer-DNA primerMcm7RFC381. Assembly of the pre-replicative complexMcm10Orc3RNA primer-DNA primerOrc3Mcm5Degraded by proteasome in cytosolMcm10Orc complexCdc6Orc1p494. Switching of origins to post-replicative stateCdt13. DNA replication initiationOrc complexOrc complexMcm4Orc2Cdc6PrimaseOrc5DNA polymerase alpha:primase: origin complexPhosphorylated Orc1p58Cdc6Cdt1Mcm7Phosphorylation ofMcm 2-7 complexMcm5Orc3Cdt1Orc2RFC36Cdt1Pre-replicative complexDegraded byproteasomein cytosolGemininOrc2Orc2RNA primer-DNA primerRNA primer-DNA primer:origin duplex:PCNAProcessive complexORC5LCDK2MCM4MCM10ATPRPA1POLA2MCM2RFC5ATPADPRFC2PRIM1UTPORC1LGTPPOLD3RPA4PRIM2ACTPMCM7ORC4LRFC3ADPORC3LUBA52PCNAGMNNRFC4dGTPCDC45LdCTPRPA2ORC2LPOLE2CDT1MCM6POLEMCM3ATPMCM5POLARFC1POLD2UBCdUTPdATPPOLD4ORC6LPOLD1CDC7ATPRPA3CDC6ASK


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org

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Quality Tags

Image:Featured.pngReview changes for Featured
Image:Curated.pngReview changes for Approved

Ontology Terms

Pathway Ontology : classical complement pathway
 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138150
Approved
view17:52, 18 March 2025HasanbalciChange line style of two edges
137505
Featured
view11:44, 3 March 2025EgonwModified description
137473view15:01, 2 March 2025EgonwModified description
128700view16:52, 20 February 2024Khanspersremoved brackets from three groups
117096view11:31, 17 May 2021EweitzModified title
107180view14:26, 17 September 2019MaintBotChEBI identifier normalization
106374view00:56, 23 August 2019KhanspersModified description
105566view06:22, 9 August 2019KhanspersModified description
104049view16:27, 27 April 2019DeSlAdded new anchor for PCNA
104048view16:21, 27 April 2019DeSlOntology Term : 'DNA replication pathway' added !
104047view16:19, 27 April 2019DeSlAdded references.
102301view20:51, 17 December 2018Khanspersremoved GenMAPP comment
96302view18:25, 7 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
94886view18:02, 11 October 2017AlexanderPicoReattached interactions to anchors
94885view18:01, 11 October 2017AlexanderPicoReattached interactions to anchors
89897view13:12, 6 October 2016MkutmonModified description
89893view13:09, 6 October 2016MkutmonModified description
89891view13:08, 6 October 2016MkutmonReverted to version '14:46, 29 April 2015' by Mkutmon
89889view13:07, 6 October 2016MkutmonModified description
79981view14:46, 29 April 2015Zari
76196view22:59, 16 June 2014MaintBotminor move - test
70091view18:20, 12 July 2013MaintBotupdating to 2013 schema
41036view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
34997view23:26, 9 February 2010KhanspersModified description
34437view18:16, 10 December 2009MaintBotAutomatic update of empty xrefs
32440view17:17, 15 August 2009MaintBotFixed text labels
32113view13:49, 14 August 2009MaintBotFixed group labels
21660view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:DNA replication Reactome]] moved to [[Pathway:WP466]]: Moved to stable identifier
13884view13:07, 19 May 2008Thomasadded connectors and merged multi-line labels
13882view13:04, 19 May 2008ThomasWIP on connectors
13880view12:50, 19 May 2008ThomasWIP on connecting lines
13055view11:12, 17 May 2008MaintBotautomated metabolite conversion
12949view10:44, 17 May 2008MaintBotSticky edges patch by Sjoerd
12482view10:24, 15 May 2008ThomasModified categories
11947view00:15, 13 May 2008KhanspersUpdated pathway
7990view13:46, 7 January 2008MaintBot[[Pathway:Human:DNA replication Reactome]] moved to [[Pathway:Homo sapiens:DNA replication Reactome]]: Renaming species
7619view16:04, 18 December 2007MaintBotfixed category names
7209view12:33, 4 November 2007MaintBotAdded categories to GPML
19417view22:17, 22 May 2007D.Korengpml file for [[Human:DNA_replication_Reactome]]
6307view22:17, 22 May 2007Kdahlquistgpml file for [[Human:DNA_replication_Reactome]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ADPMetabolite58-64-0 (CAS)
ASKGeneProduct10926 (Entrez Gene)
ATPMetabolite1927-31-7 (CAS)
CDC45LGeneProduct8318 (Entrez Gene)
CDC6GeneProduct990 (Entrez Gene)
CDC7GeneProduct8317 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDT1GeneProduct81620 (Entrez Gene)
CTPMetabolite65-47-4 (CAS)
GMNNGeneProduct51053 (Entrez Gene)
GTPMetabolite2564-35-4 (CAS)
MCM10GeneProduct55388 (Entrez Gene)
MCM2GeneProduct4171 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM5GeneProduct4174 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
ORC1LGeneProduct4998 (Entrez Gene)
ORC2LGeneProduct4999 (Entrez Gene)
ORC3LGeneProduct23595 (Entrez Gene)
ORC4LGeneProduct5000 (Entrez Gene)
ORC5LGeneProduct5001 (Entrez Gene)
ORC6LGeneProduct23594 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
POLA2GeneProduct23649 (Entrez Gene)
POLAGeneProduct5422 (Entrez Gene)
POLD1GeneProduct5424 (Entrez Gene)
POLD2GeneProduct5425 (Entrez Gene)
POLD3GeneProduct10714 (Entrez Gene)
POLD4GeneProduct57804 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRIM2AGeneProductENSG00000146143 (Ensembl)
RFC1GeneProduct5981 (Entrez Gene)
RFC2GeneProduct5982 (Entrez Gene)
RFC3GeneProduct5983 (Entrez Gene)
RFC4GeneProduct5984 (Entrez Gene)
RFC5GeneProduct5985 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2GeneProduct6118 (Entrez Gene)
RPA3GeneProduct6119 (Entrez Gene)
RPA4GeneProduct29935 (Entrez Gene)
UBA52GeneProduct7311 (Entrez Gene)
UBCGeneProduct7316 (Entrez Gene)
UTPMetabolite9850 (ChEBI)
dATPMetabolite1927-31-7 (CAS)
dCTPMetabolite2056-98-6 (CAS)
dGTPMetabolite2564-35-4 (CAS)
dUTPMetabolite17625 (ChEBI)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP466"
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