Nicotine metabolism in liver cells (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Hukkanen J, Jacob P 3rd, Benowitz NL; ''Metabolism and disposition kinetics of nicotine.''; Pharmacol Rev, 2005 PubMed Europe PMC Scholia
2. Benowitz NL, Hukkanen J, Jacob P 3rd; ''Nicotine chemistry, metabolism, kinetics and biomarkers.''; Handb Exp Pharmacol, 2009 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	119518	view	14:14, 8 July 2021	DeSl	Removed license item
	119517	view	14:13, 8 July 2021	DeSl	Updated shape of proteins; converted arrows to MIM types.
	117166	view	09:50, 18 May 2021	Eweitz	Modified title
	106147	view	12:04, 16 August 2019	MaintBot	HMDB identifier normalization
	99039	view	08:54, 26 October 2018	DeSl	Modified description
	96391	view	07:15, 12 March 2018	Asios Olia	Modified description
	96390	view	07:13, 12 March 2018	Asios Olia	Modified description
	96389	view	07:07, 12 March 2018	Asios Olia	Modified description
	96388	view	07:06, 12 March 2018	Asios Olia	Modified description
	96387	view	07:05, 12 March 2018	Asios Olia	Modified description
	96386	view	07:05, 12 March 2018	Asios Olia	Modified description
	92822	view	19:45, 8 July 2017	AlexanderPico	Ontology Term : 'drug pathway' added !
	92778	view	11:30, 4 July 2017	DeSl	Ontology Term : 'xenobiotic metabolic pathway' added !
	90593	view	07:00, 28 November 2016	Egonw	Modified description
	90565	view	09:49, 25 November 2016	Egonw	Added two lit references.
	89933	view	13:44, 6 October 2016	Egonw	Modified description
	70113	view	19:10, 12 July 2013	MaintBot	updated to 2013 schema
	70026	view	01:53, 12 July 2013	AlexanderPico	Modified title
	67507	view	11:18, 26 June 2013	Ddigles	Ontology Term : 'nicotine pathway' added !
	56442	view	21:37, 7 January 2013	Egonw	Added a missing HMDB data source value.
	46348	view	12:55, 19 January 2012	Egonw	Periodical save, work in progress
	45359	view	20:45, 7 October 2011	Khanspers	Ontology Term : 'hepatocyte' added !
	41180	view	23:42, 1 March 2011	MaintBot	Removed redundant pathway information and comments
	38479	view	18:19, 17 September 2010	AlexanderPico	Modified description
	38342	view	20:45, 1 September 2010	Khanspers	Changed name
	38341	view	19:16, 1 September 2010	Khanspers	Modified description
	38329	view	18:47, 1 September 2010	Khanspers	Changed DataNode type and arrows
	38300	view	21:16, 30 August 2010	Khanspers	Changed arrows to catalysis
	38299	view	21:14, 30 August 2010	Khanspers	Modified description
	38298	view	21:13, 30 August 2010	Khanspers	Modified description
	38297	view	21:12, 30 August 2010	Khanspers	Modified description
	38218	view	20:52, 27 August 2010	Khanspers	Modified categories
	38217	view	20:50, 27 August 2010	Khanspers	Modified description
	38216	view	20:49, 27 August 2010	Khanspers	Changed name
	38215	view	20:48, 27 August 2010	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
3'-Hydroxycotinine glucuronide	Metabolite	HMDB01204 (HMDB)
3'-Hydroxycotinine	Metabolite	HMDB01390 (HMDB)
5'-Hydroxycotinine	Metabolite	HMDB01427 (HMDB)
AOX1	GeneProduct	316 (Entrez Gene)
CYP2A6	GeneProduct	1548 (Entrez Gene)
CYP2B6	GeneProduct	1555 (Entrez Gene)
Cotinine N-oxide	Metabolite	HMDB01411 (HMDB)
Cotinine	Metabolite	HMDB01046 (HMDB)
Cotinineglucuronide	Metabolite	HMDB01013 (HMDB)
FMO3	GeneProduct	2328 (Entrez Gene)
Nicotine iminium ion	Metabolite	HMDB01010 (HMDB)
Nicotine-Gluc	Metabolite	HMDB01272 (HMDB)
Nicotine-N-oxide	Metabolite	HMDB01497 (HMDB)
Nicotine	Metabolite	HMDB01934 (HMDB)
Nornicotine	Metabolite	HMDB01126 (HMDB)
UGT1A4	GeneProduct	54657 (Entrez Gene)
UGT1A9	GeneProduct	54600 (Entrez Gene)

Annotated Interactions

No annotated interactions