mRNA, protein, and metabolite inducation pathway by cyclosporin A (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Nrf2ATF4L-leucineROSL-IsoleucineSLC3A2SLC7A5SLC1A5L-tyrosineL-ValineL-tryptophanL-threonineL-alanineL-glutamineL-asparagineSLC3A2SLC7A5SLC1A5KEAP1KEAP1ATF4Name: mRNA, protein, and metabolite inducation pathway by cyclosporin AOrganism: Homo sapiens


Description

Exposure to cyclosporin A triggers a cascade of changes in expression and abundance of various mRNAs, proteins, and metabolites, which can be measured experimentally.

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:MissingXref.pngAnnotate nodes
Image:Curated.pngReview changes for Approved

Ontology Terms

 

Bibliography

  1. Wilmes A, Limonciel A, Aschauer L, Moenks K, Bielow C, Leonard MO, Hamon J, Carpi D, Ruzek S, Handler A, Schmal O, Herrgen K, Bellwon P, Burek C, Truisi GL, Hewitt P, Di Consiglio E, Testai E, Blaauboer BJ, Guillou C, Huber CG, Lukas A, Pfaller W, Mueller SO, Bois FY, Dekant W, Jennings P; ''Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress.''; J Proteomics, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106206
Approved
view12:10, 16 August 2019MaintBotHMDB identifier normalization
96732view08:07, 1 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94203view20:58, 25 August 2017DeSlAnnotated metabolite nodes with missing IDs.
92352view07:26, 29 May 2017FehrhartAdded some annotations
91623view18:35, 24 March 2017Khanspersconnected one interaction
91027view22:56, 22 December 2016EgonwMore content of the figure.
91002view12:46, 20 December 2016ElisaAll lines are connected
90927view16:27, 18 December 2016EgonwOntology Term : 'xenobiotic metabolic pathway' added !
90926view16:19, 18 December 2016EgonwModified description
90925view16:17, 18 December 2016EgonwModified title
90924view16:15, 18 December 2016EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ATF4GeneProductENSG00000128272 (Ensembl)
ATF4ProteinQ96AQ3 (Uniprot-TrEMBL)
KEAP1ProteinENSG00000079999 (Ensembl)
L-IsoleucineMetaboliteCHEBI:17191 (ChEBI)
L-ValineMetaboliteCHEBI:6321 (ChEBI)
L-alanineMetaboliteCHEBI:16977 (ChEBI)
L-asparagineMetaboliteCHEBI:17196 (ChEBI)
L-glutamineMetaboliteCHEBI:18050 (ChEBI)
L-leucineMetaboliteCHEBI:15603 (ChEBI)
L-threonineMetaboliteCHEBI:16857 (ChEBI)
L-tryptophanMetaboliteCHEBI:21407 (ChEBI)
L-tyrosineMetaboliteCHEBI:17895 (ChEBI)
Nrf2ProteinQ16236 (Uniprot-TrEMBL)
ROSMetaboliteQ424361 (Wikidata)
SLC1A5GeneProductENSG00000105281 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)

Annotated Interactions

No annotated interactions

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