Nicotine metabolism in liver cells (Homo sapiens)

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1, 2Liver cellCotinineCYP2A6Nicotine-N-oxideNornicotineNicotine-GlucNicotineCYP2A6NornicotineNicotine-N-oxideUGT1A43'-Hydroxycotinine glucuronideCotinineCotinine N-oxide3'-HydroxycotinineCotinineglucuronideCotinine N-oxideNicotine3'-Hydroxycotinine glucuronideNornicotineNicotine-GlucNicotine iminium ionFMO35'-HydroxycotinineNornicotine5'-HydroxycotinineUGT1A9CYP2A6CYP2B63'-HydroxycotinineCotinineglucuronideAOX1


Description

Nicotine results in many metabolites after metabolization in the liver.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hukkanen J, Jacob P 3rd, Benowitz NL; ''Metabolism and disposition kinetics of nicotine.''; Pharmacol Rev, 2005 PubMed Europe PMC Scholia
  2. Benowitz NL, Hukkanen J, Jacob P 3rd; ''Nicotine chemistry, metabolism, kinetics and biomarkers.''; Handb Exp Pharmacol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
119518view14:14, 8 July 2021DeSlRemoved license item
119517view14:13, 8 July 2021DeSlUpdated shape of proteins; converted arrows to MIM types.
117166view09:50, 18 May 2021EweitzModified title
106147view12:04, 16 August 2019MaintBotHMDB identifier normalization
99039view08:54, 26 October 2018DeSlModified description
96391view07:15, 12 March 2018Asios OliaModified description
96390view07:13, 12 March 2018Asios OliaModified description
96389view07:07, 12 March 2018Asios OliaModified description
96388view07:06, 12 March 2018Asios OliaModified description
96387view07:05, 12 March 2018Asios OliaModified description
96386view07:05, 12 March 2018Asios OliaModified description
92822view19:45, 8 July 2017AlexanderPicoOntology Term : 'drug pathway' added !
92778view11:30, 4 July 2017DeSlOntology Term : 'xenobiotic metabolic pathway' added !
90593view07:00, 28 November 2016EgonwModified description
90565view09:49, 25 November 2016EgonwAdded two lit references.
89933view13:44, 6 October 2016EgonwModified description
70113view19:10, 12 July 2013MaintBotupdated to 2013 schema
70026view01:53, 12 July 2013AlexanderPicoModified title
67507view11:18, 26 June 2013DdiglesOntology Term : 'nicotine pathway' added !
56442view21:37, 7 January 2013EgonwAdded a missing HMDB data source value.
46348view12:55, 19 January 2012EgonwPeriodical save, work in progress
45359view20:45, 7 October 2011KhanspersOntology Term : 'hepatocyte' added !
41180view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38479view18:19, 17 September 2010AlexanderPicoModified description
38342view20:45, 1 September 2010KhanspersChanged name
38341view19:16, 1 September 2010KhanspersModified description
38329view18:47, 1 September 2010KhanspersChanged DataNode type and arrows
38300view21:16, 30 August 2010KhanspersChanged arrows to catalysis
38299view21:14, 30 August 2010KhanspersModified description
38298view21:13, 30 August 2010KhanspersModified description
38297view21:12, 30 August 2010KhanspersModified description
38218view20:52, 27 August 2010KhanspersModified categories
38217view20:50, 27 August 2010KhanspersModified description
38216view20:49, 27 August 2010KhanspersChanged name
38215view20:48, 27 August 2010KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3'-Hydroxycotinine glucuronideMetaboliteHMDB01204 (HMDB)
3'-HydroxycotinineMetaboliteHMDB01390 (HMDB)
5'-HydroxycotinineMetaboliteHMDB01427 (HMDB)
AOX1GeneProduct316 (Entrez Gene)
CYP2A6GeneProduct1548 (Entrez Gene)
CYP2B6GeneProduct1555 (Entrez Gene)
Cotinine N-oxideMetaboliteHMDB01411 (HMDB)
CotinineMetaboliteHMDB01046 (HMDB)
CotinineglucuronideMetaboliteHMDB01013 (HMDB)
FMO3GeneProduct2328 (Entrez Gene)
Nicotine iminium ionMetaboliteHMDB01010 (HMDB)
Nicotine-GlucMetaboliteHMDB01272 (HMDB)
Nicotine-N-oxideMetaboliteHMDB01497 (HMDB)
NicotineMetaboliteHMDB01934 (HMDB)
NornicotineMetaboliteHMDB01126 (HMDB)
UGT1A4GeneProduct54657 (Entrez Gene)
UGT1A9GeneProduct54600 (Entrez Gene)

Annotated Interactions

No annotated interactions

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