Ubiquinone biosynthesis (Saccharomyces cerevisiae)

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1-16trans, trans-farnesyl diphosphateNAD3,4-dihydroxy-5-hexaprenylbenzoatespontaneous4-coumaratep-hydroxyphenylpyruvateO2S-adenosyl-L-methioninegeranyl-PPS-adenosyl-L-methioninedelta3-isopentenyl-PPgeranylfarnesyl-diphosphateCO2delta3-isopentenyl-PPNH3O2p-coumaroyl-CoAhexaprenyl-diphosphateS-adenosyl-homocysteine6-methoxy-1,4-benzoquinolH2O2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol2-hexaprenyl-6-methoxyphenolO23-hexaprenyl-4-hydroxybenzoate2-hexaprenyl-3-methyl-5-hydroxy-delta3-isopentenyl-PPdelta3-isopentenyl-PPpyruvateS-adenosyl-homocysteine2-hexaprenyl-6-methoxy-1,4-benzoquinoldimethylallyl-pyrophosphateupiquinone(30)p-hydroxybenzoateS-adenosyl-homocysteine4-hydroxybenzoyl-CoAdelta3-isopentenyl-PPS-adenosyl-L-methionine4-hydroxy-phenyllactate3-methoxy-4-hydroxy-5-hexaprenylbenzoateubiquinol(30)ERG20ATPCOQ1COQ2pyrophosphateCOQ3pyrophosphateBTS1geranylgeranyl-PPpyrophosphateCOQ6pyrophosphateNADHCOQ5COQ3pyrophosphateERG20pyrophosphateacetyl-CoAchorismateCAT5Coenzyme ACoenzyme AL-tyrosine


Description

reference for curation (EC.: 4.99.1.1) Karlberg, T., et al. Biochemistry (2002) 46:13499-13506. (EC:1.3.3.3) Labbe, P. Methods Enzymol (1997) 281:367-378. SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

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Bibliography

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  1. Tran UC, Clarke CF; ''Endogenous synthesis of coenzyme Q in eukaryotes.''; Mitochondrion, 2007 PubMed Europe PMC Scholia
  2. Meganathan R; ''Ubiquinone biosynthesis in microorganisms.''; FEMS Microbiol Lett, 2001 PubMed Europe PMC Scholia
  3. Marbois B, Gin P, Faull KF, Poon WW, Lee PT, Strahan J, Shepherd JN, Clarke CF; ''Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  4. Baba SW, Belogrudov GI, Lee JC, Lee PT, Strahan J, Shepherd JN, Clarke CF; ''Yeast Coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme Q biosynthesis.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  5. Lobo Z, Maitra PK; ''Genetics of Yeast Hexokinase.''; Genetics, 1977 PubMed Europe PMC Scholia
  6. Belogrudov GI, Lee PT, Jonassen T, Hsu AY, Gin P, Clarke CF; ''Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis.''; Arch Biochem Biophys, 2001 PubMed Europe PMC Scholia
  7. Jonassen T, Proft M, Randez-Gil F, Schultz JR, Marbois BN, Entian KD, Clarke CF; ''Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  8. SUGIMURA T, RUDNEY H; ''The adaptive formation of ubiquinone 30 (coenzyme Q6) in yeast.''; Biochim Biophys Acta, 1960 PubMed Europe PMC Scholia
  9. Tran UC, Marbois B, Gin P, Gulmezian M, Jonassen T, Clarke CF; ''Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  10. Ashby MN, Edwards PA; ''Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  11. Hsu AY, Poon WW, Shepherd JA, Myles DC, Clarke CF; ''Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis.''; Biochemistry, 1996 PubMed Europe PMC Scholia
  12. Gin P, Clarke CF; ''Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  13. Olson RE, Rudney H; ''Biosynthesis of ubiquinone.''; Vitam Horm, 1983 PubMed Europe PMC Scholia
  14. Casey J, Threlfall DR; ''Synthesis of 5-demethoxyubiquinone-6 and ubiquinone-6 from 3-hexaprenyl-4-hydroxybenzoate in yeast mitochondria.''; FEBS Lett, 1978 PubMed Europe PMC Scholia
  15. Hsieh EJ, Gin P, Gulmezian M, Tran UC, Saiki R, Marbois BN, Clarke CF; ''Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex.''; Arch Biochem Biophys, 2007 PubMed Europe PMC Scholia
  16. Dibrov E, Robinson KM, Lemire BD; ''The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain.''; J Biol Chem, 1997 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118129view10:34, 25 May 2021EweitzModified title
107255view14:35, 17 September 2019MaintBotChEBI identifier normalization
92972view17:40, 21 July 2017KhanspersModified description
92971view17:40, 21 July 2017Khanspersremoved GenMAPP notes
92920view11:02, 17 July 2017DeSlChanged CAs to ChEBI ID (more stereospecific).
69850view16:03, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69644view20:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
67735view11:56, 26 June 2013DdiglesOntology Term : 'ubiquinone biosynthetic pathway' added !
41882view04:52, 2 March 2011MaintBotRemoved redundant pathway information and comments
36654view22:40, 9 April 2010MaintBotDescription and bibliography added from SGD
21327view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Ubiquinone Biosynthesis]] moved to [[Pathway:WP308]]: Moved to stable identifier
12889view08:07, 17 May 2008MaintBotautomated metabolite conversion
8999view14:14, 7 January 2008MaintBotAdded to category $category
8997view14:14, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
BTS1GeneProductS000005990 (SGD)
CAT5GeneProductS000005651 (SGD)
COQ1GeneProductS000000207 (SGD)
COQ2GeneProductS000005324 (SGD)
COQ3GeneProductS000005456 (SGD)
COQ5GeneProductS000004578 (SGD)
COQ6GeneProductS000003487 (SGD)
Coenzyme AMetabolite64885-97-8 (CAS)
ERG20GeneProductS000003703 (SGD)
L-tyrosineMetabolite60-18-4 (CAS)
NADHMetabolite53-84-9 (CAS)
acetyl-CoAMetabolite72-89-9 (CAS)
chorismateMetabolite17333 (ChEBI)
geranylgeranyl-PPMetabolite6699-20-3 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions
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