Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs) bind specific sets of RNA and regulate their translation, stability, and subcellular localization. IGF2BP1, IGF2BP2, and IGF2BP3 bind about 8400 protein-coding transcripts. The target RNAs contain the sequence motif CAUH (where H is A, U, or, C) and binding of IGFBPs increases the stability of the target RNAs.
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Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, Buchmeier S, Wahle E, Hüttelmaier S.; ''Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.''; PubMedEurope PMCScholia
Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J.; ''H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein.''; PubMedEurope PMCScholia
Noubissi FK, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, Spiegelman VS.; ''CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling.''; PubMedEurope PMCScholia
Christiansen J, Kolte AM, Hansen Tv, Nielsen FC.; ''IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes.''; PubMedEurope PMCScholia
Hüttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X, Bassell GJ, Condeelis J, Singer RH.; ''Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.''; PubMedEurope PMCScholia
Nielsen FC, Nielsen J, Christiansen J.; ''A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.''; PubMedEurope PMCScholia
Yisraeli JK.; ''VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.''; PubMedEurope PMCScholia
Lemm I, Ross J.; ''Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant.''; PubMedEurope PMCScholia
Oberman F, Rand K, Maizels Y, Rubinstein AM, Yisraeli JK.; ''VICKZ proteins mediate cell migration via their RNA binding activity.''; PubMedEurope PMCScholia
Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schäfer SA, Häring HU, 't Hart LM, van Haeften TW.; ''Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.''; PubMedEurope PMCScholia
Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T.; ''Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.''; PubMedEurope PMCScholia
Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC.; ''A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.''; PubMedEurope PMCScholia
Chao JA, Patskovsky Y, Patel V, Levy M, Almo SC, Singer RH.; ''ZBP1 recognition of beta-actin zipcode induces RNA looping.''; PubMedEurope PMCScholia
Ioannidis P, Mahaira L, Papadopoulou A, Teixeira MR, Heim S, Andersen JA, Evangelou E, Dafni U, Pandis N, Trangas T.; ''CRD-BP: a c-Myc mRNA stabilizing protein with an oncofetal pattern of expression.''; PubMedEurope PMCScholia
Insulin-like Growth Factor mRNA Binding Factor-3 (IGF2BP3, also known as IMP3 and VICKZ3) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA. Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP3 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
Insulin-like Growth Factor mRNA Binding Factor-2 (IGF2BP2, also known as IMP2 and VICKZ2) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA. Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP2 at the 5' UTR, repressing translation (Other isoforms of IGF2 are constitutive). IGF2BP2 may be a causal factor in type 2 diabetes.
Insulin-like Growth Factor mRNA Binding Factor-1 (IGF2BP1, also known as ZBP1, CRD-BP, IMP1, and VICKZ1) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA. Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP1 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive). ZBP1 (IGF2BP1) uses its third and fourth KH domains to recognize the first 28 nts of the 3' UTR of Beta actin mRNA. The KH domains are arranged as an anti-parallel pseudo-dimer that specifically recognize a bipartite element located in this RNA sequence. MYC (c-MYC) and Beta-TRCP1 mRNAs are bound at sites termed Coding Region Determinants (CDRs) in the open reading frame of the message. Binding of the MYC mRNA shields it from degradation and increases its half-life The CD44 mRNA is bound at the 3' UTR. IGF2BP1 also binds the non-coding, imprinted H19 RNA.
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Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP3 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP2 at the 5' UTR, repressing translation (Other isoforms of IGF2 are constitutive).
IGF2BP2 may be a causal factor in type 2 diabetes.
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP1 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
ZBP1 (IGF2BP1) uses its third and fourth KH domains to recognize the first 28 nts of the 3' UTR of Beta actin mRNA. The KH domains are arranged as an anti-parallel pseudo-dimer that specifically recognize a bipartite element located in this RNA sequence.
MYC (c-MYC) and Beta-TRCP1 mRNAs are bound at sites termed Coding Region Determinants (CDRs) in the open reading frame of the message. Binding of the MYC mRNA shields it from degradation and increases its half-life
The CD44 mRNA is bound at the 3' UTR.
IGF2BP1 also binds the non-coding, imprinted H19 RNA.