DNA IR-damage and cellular response via ATR (Homo sapiens)

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636. Cantor S, Drapkin R, Zhang F, Lin Y, Han J, Pamidi S, Livingston DM; ''The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
637. Singleton MR, Wentzell LM, Liu Y, West SC, Wigley DB; ''Structure of the single-strand annealing domain of human RAD52 protein.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
638. Yu X, Fu S, Lai M, Baer R, Chen J; ''BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.''; Genes Dev, 2006 PubMed Europe PMC Scholia
639. Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY; ''Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.''; Genes Dev, 2008 PubMed Europe PMC Scholia
640. Huang X, Tran T, Zhang L, Hatcher R, Zhang P; ''DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
641. Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF; ''ATM associates with and phosphorylates p53: mapping the region of interaction.''; Nat Genet, 1998 PubMed Europe PMC Scholia
642. Chiang SC, Carroll J, El-Khamisy SF; ''TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage.''; Cell Cycle, 2010 PubMed Europe PMC Scholia
643. Zou L, Liu D, Elledge SJ; ''Replication protein A-mediated recruitment and activation of Rad17 complexes.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
644. Temmerman ST, Ma CA, Borges L, Kubin M, Liu S, Derry JM, Jain A; ''Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination.''; Blood, 2006 PubMed Europe PMC Scholia
645. Ahn J, Urist M, Prives C; ''The Chk2 protein kinase.''; DNA Repair (Amst), 2004 PubMed Europe PMC Scholia
646. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ; ''Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.''; Genes Dev, 2000 PubMed Europe PMC Scholia
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648. Tréand C, du Chéné I, Brès V, Kiernan R, Benarous R, Benkirane M, Emiliani S; ''Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.''; EMBO J, 2006 PubMed Europe PMC Scholia
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677. Noll A, Ruppenthal SL, Montenarh M; ''The mitotic phosphatase cdc25C at the Golgi apparatus.''; Biochem Biophys Res Commun, 2006 PubMed Europe PMC Scholia
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679. Pampin M, Simonin Y, Blondel B, Percherancier Y, Chelbi-Alix MK; ''Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense.''; J Virol, 2006 PubMed Europe PMC Scholia
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681. Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J; ''Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.''; Cancer Cell, 2003 PubMed Europe PMC Scholia
682. Thacker J, Ganesh AN; ''DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants: comparisons to ataxia-telangiectasia cells.''; Mutat Res, 1990 PubMed Europe PMC Scholia
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684. Sharma S, Sommers JA, Driscoll HC, Uzdilla L, Wilson TM, Brosh RM Jr; ''The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
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686. Shen B, Nolan JP, Sklar LA, Park MS; ''Essential amino acids for substrate binding and catalysis of human flap endonuclease 1.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
687. Yin J, Sobeck A, Xu C, Meetei AR, Hoatlin M, Li L, Wang W; ''BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.''; EMBO J, 2005 PubMed Europe PMC Scholia
688. Yang XH, Zou L; ''Checkpoint and coordinated cellular responses to DNA damage.''; Results Probl Cell Differ, 2006 PubMed Europe PMC Scholia
689. Maldonado-Codina G, Glover DM; ''Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos.''; J Cell Biol, 1992 PubMed Europe PMC Scholia
690. Li L, Peterson CA, Kanter-Smoler G, Wei YF, Ramagli LS, Sunnerhagen P, Siciliano MJ, Legerski RJ; ''hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.''; Oncogene, 1999 PubMed Europe PMC Scholia
691. Wu L, Bachrati CZ, Ou J, Xu C, Yin J, Chang M, Wang W, Li L, Brown GW, Hickson ID; ''BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
692. Ou YH, Chung PH, Sun TP, Shieh SY; ''p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.''; Mol Biol Cell, 2005 PubMed Europe PMC Scholia
693. Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J; ''Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.''; Nat Cell Biol, 2008 PubMed Europe PMC Scholia
694. Lehner CF, O'Farrell PH; ''The roles of Drosophila cyclins A and B in mitotic control.''; Cell, 1990 PubMed Europe PMC Scholia
695. Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H; ''Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
696. Yuan J, Chen J; ''N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
697. White DE, Negorev D, Peng H, Ivanov AV, Maul GG, Rauscher FJ 3rd; ''KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions.''; Cancer Res, 2006 PubMed Europe PMC Scholia
698. Buchko GW, Daughdrill GW, de Lorimier R, Rao B K, Isern NG, Lingbeck JM, Taylor JS, Wold MS, Gochin M, Spicer LD, Lowry DF, Kennedy MA; ''Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies.''; Biochemistry, 1999 PubMed Europe PMC Scholia
699. Tanaka H, Mendonca MS, Bradshaw PS, Hoelz DJ, Malkas LH, Meyn MS, Gilley D; ''DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
700. Foray N, Marot D, Gabriel A, Randrianarison V, Carr AM, Perricaudet M, Ashworth A, Jeggo P; ''A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.''; EMBO J, 2003 PubMed Europe PMC Scholia
701. Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S; ''Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.''; EMBO J, 2009 PubMed Europe PMC Scholia
702. Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM; ''Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNFcomplex.''; Hum Mol Genet, 2001 PubMed Europe PMC Scholia
703. Tsao CC, Geisen C, Abraham RT; ''Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling.''; EMBO J, 2004 PubMed Europe PMC Scholia
704. David Y, Ziv T, Admon A, Navon A; ''The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
705. Ziółkowska-Suchanek I, Mosor M, Wierzbicka M, Rydzanicz M, Baranowska M, Nowak J; ''The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.''; Mol Cancer, 2013 PubMed Europe PMC Scholia
706. Dou H, Huang C, Singh M, Carpenter PB, Yeh ET; ''Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.''; Mol Cell, 2010 PubMed Europe PMC Scholia
707. Tan Y, Raychaudhuri P, Costa RH; ''Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes.''; Mol Cell Biol, 2007 PubMed Europe PMC Scholia
708. Bauerschmidt C, Woodcock M, Stevens DL, Hill MA, Rothkamm K, Helleday T; ''Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells.''; Exp Cell Res, 2011 PubMed Europe PMC Scholia
709. Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, Livingston DM; ''Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.''; Mol Cell, 2006 PubMed Europe PMC Scholia
710. Fujimoto H, Onishi N, Kato N, Takekawa M, Xu XZ, Kosugi A, Kondo T, Imamura M, Oishi I, Yoda A, Minami Y; ''Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.''; Cell Death Differ, 2006 PubMed Europe PMC Scholia
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History

External references

DataNodes

Name	Type	Database reference	Comment
ATM	GeneProduct	ENSG00000149311 (Ensembl)
ATRIP	Protein	Q8WXE1 (Uniprot-TrEMBL)
ATR	Protein	Q13535 (Uniprot-TrEMBL)	From Pathway: SPIKE 00003
BARD1	Protein	Q99728 (Uniprot-TrEMBL)
BCL6	Protein	P41182 (Uniprot-TrEMBL)
BLM	Protein
BRCA1	Protein	P38398 (Uniprot-TrEMBL)
BRCA2	Protein	P51587 (Uniprot-TrEMBL)
BRCC3	Protein	P46736 (Uniprot-TrEMBL)
BRIP1	Protein	Q9BX63 (Uniprot-TrEMBL)
CDC25C	Protein	P30307 (Uniprot-TrEMBL)
CDC45	Protein	O75419 (Uniprot-TrEMBL)
CEP164	Protein	Q9UPV0 (Uniprot-TrEMBL)
CHK1	Protein	O14757 (Uniprot-TrEMBL)
CHK2	Protein	O96017 (Uniprot-SwissProt)
CLK2	Protein	P49760 (Uniprot-TrEMBL)
CLSPN	Protein	Q9HAW4 (Uniprot-TrEMBL)
Cdc2	Protein	P06493 (Uniprot-TrEMBL)
Cdk2	Protein	P24941 (Uniprot-TrEMBL)
Cell Cycle Checkpoint Activation	Pathway	WP1775 (WikiPathways)
Cellular response to DNA damage	Pathway
CycA	Protein	P14785 (Uniprot-TrEMBL)
CycB	Protein	P20439 (Uniprot-TrEMBL)
DCLRE1A	Protein	Q6PJP8 (Uniprot-TrEMBL)
DNA Polymerase delta tetramer	Protein
DNA Repair	Pathway	WP707 (WikiPathways)
Damage Processing	Pathway
E2F1	Protein	Q01094 (Uniprot-TrEMBL)
EEF1E1	Protein	O43324 (Uniprot-TrEMBL)
EXO1	Protein	Q9UQ84 (Uniprot-TrEMBL)
FAM175A	Protein	Q6UWZ7 (Uniprot-TrEMBL)
FANCA	Protein	O15360 (Uniprot-TrEMBL)
FANCD2	Protein	Q9BXW9 (Uniprot-SwissProt)
FANCD2	Protein	Q9BXW9 (Uniprot-TrEMBL)
FANCI	Protein	Q9NVI1 (Uniprot-TrEMBL)
FEN1	Protein	P39748 (Uniprot-TrEMBL)
FOXM1	Protein	Q08050 (Uniprot-TrEMBL)
G1/S boundary activation	Pathway
G2/M-Phase Checkpoint	Pathway	R-HSA-69481 (Reactome)
Gamma H2AX	Protein	P16104 (Uniprot-TrEMBL)
H2AX	Protein	P16104 (Uniprot-TrEMBL)
HERC2	Protein	O95714 (Uniprot-TrEMBL)
HUS1	Protein	O60921 (Uniprot-TrEMBL)
IKPKB	Protein	Q9Y6K9 (Uniprot-TrEMBL)
M-Phase Progression	Pathway	hsa04110 (KEGG Pathway)
MCM2	Protein	P49736 (Uniprot-TrEMBL)
MCPH1	Protein	Q8NEM0 (Uniprot-TrEMBL)
MDC1	Protein	Q14676 (Uniprot-TrEMBL)
MDM2	Protein	Q00987 (Uniprot-TrEMBL)
MRE11A	Protein	P49959 (Uniprot-TrEMBL)
MSH2	Protein	P43246 (Uniprot-TrEMBL)
MUTL-ALPHA MLH1	Protein	P40692 (Uniprot-TrEMBL)
NBN	Protein	O60934 (Uniprot-TrEMBL)
PALB2	Protein	Q86YC2 (Uniprot-TrEMBL)
PARP1	Protein	P09874 (Uniprot-TrEMBL)
PCNA	Protein	P12004 (Uniprot-TrEMBL)
PLK1	Protein	P53350 (Uniprot-TrEMBL)
PML	Protein	P29590 (Uniprot-TrEMBL)
POLB	Protein	P06746 (Uniprot-TrEMBL)
POLN	Protein	Q7Z5Q5 (Uniprot-TrEMBL)
PPM1D	Protein	O15297 (Uniprot-TrEMBL)
PRKDC	Protein	P78527 (Uniprot-TrEMBL)
RAD17	Protein	O75943 (Uniprot-TrEMBL)
RAD1	Protein	O60671 (Uniprot-TrEMBL)
RAD50	Protein	Q92878 (Uniprot-TrEMBL)
RAD51	Protein	Q06609 (Uniprot-TrEMBL)
RAD52	Protein	P43351 (Uniprot-TrEMBL)
RAD9	Protein	Q99638 (Uniprot-TrEMBL)
RBBP8	Protein	Q99708 (Uniprot-TrEMBL)
RECQL4	Protein	O94761 (Uniprot-TrEMBL)
RECQL5	Protein	O94762 (Uniprot-TrEMBL)
RECQL	Protein	P46063 (Uniprot-TrEMBL)
RFWD3	Protein	Q6PCD5 (Uniprot-TrEMBL)
RMI1	Protein	Q9H9A7 (Uniprot-TrEMBL)
RNF8	Protein
RPA1	Protein
RPA1	Protein	P27694 (Uniprot-TrEMBL)
RPA2	Protein	P15927 (Uniprot-TrEMBL)
RecQ-like helicases
SHFM1	Protein	P60896 (Uniprot-TrEMBL)
SMARCAL1	Protein	Q9NZC9 (Uniprot-TrEMBL)
SMARCC2	Protein	Q8TAQ2 (Uniprot-TrEMBL)
SMC1A	Protein	Q14683 (Uniprot-TrEMBL)
SP1	Protein	P08047 (Uniprot-TrEMBL)
TDP1	Protein	Q9NUW8 (Uniprot-TrEMBL)
TOP3A	Protein	Q13472 (Uniprot-TrEMBL)
TOPBP1	Protein	Q92547 (Uniprot-TrEMBL)
TP53BP1	Protein	Q12888 (Uniprot-TrEMBL)
TP53	Protein	P04637 (Uniprot-TrEMBL)
TRIM28	Protein	Q13263 (Uniprot-TrEMBL)
The intra-S-phase checkpoint mediated arrest of cell cycle progression	Pathway	R-HSA-5693571 (Reactome)
UB2D3	Protein	P61077 (Uniprot-TrEMBL)
UIMC1	Protein	Q96RL1 (Uniprot-TrEMBL)
UPF1	Protein	Q92900 (Uniprot-TrEMBL)
USP1	Protein	O94782 (Uniprot-TrEMBL)
WRN	Protein	Q14191 (Uniprot-TrEMBL)
XPA	Protein	P23025 (Uniprot-TrEMBL)
XRCC5	Protein	P13010 (Uniprot-TrEMBL)
ssDNA

Annotated Interactions

Source	Target	Type	Database reference	Comment
ATM	TP53	mim-stimulation	00006 (SPIKE)