Histidine, purine, and pyrimidine superpathway (Saccharomyces cerevisiae)
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H2O
NAD
phosphoribosyl-ATP
NAD
H2O
reduced flavodoxin
oxidized flavodoxin
AMP
reduced thioredoxin
carbamoyl-phosphate
dihydroorotate
AMP
CTP
phosphoribosyl-formamido-carboxamide
L-aspartate
5-phospho-ribosyl-glycineamide
THF
H2O
H2O
phosphoribulosylformimino-AICAR-P
imidazole acetol-phosphate
UDP
H2O
histidinal
histidinol
UMP
5’-phosphoribosyl-5-aminoimidazole
acceptor
NAD
orotidine-5’-phosphate
5’-phosphoribosyl-4-(N-
H+
orotate
L-aspartate
CO2
fumerate
H+
THF
H2O
H2O
phosphoribosylformiminoAICAR-phosphate
phosphoribosyl-carboxy-aminoimidazole
5-phosphoribosylamine
H2O
H2O
AMP
oxidized thioredoxin
UTP
5’-phosphoribosyl-N-formylglycineamide
CO2
deoxy-GTP
IMP
D-erythro-imidazole-glycerol-phosphate
2-oxoglutarate
H2O
H2O
H2O
5-phosphoribosyl-n-formylglycineamidine
carbamoyl-L-aspartate
HCO3
reduced acceptor
H+
H2O
H2O
phosphoribosyl-AMP
H2O
sucinocarboxamide)-5-aminoimidazole
H2O
NH3
GUK1
PRS2
ADE8
phosphate
L-glutamine
ADP
GUA1
HIS6
ADE13
phosphate
ATP
CDP
HIS5
HIS4
NADH
ADE1
ADP
HIS4
ATP
pyrophosphate
L-histidinol-phosphate
IMD4
10-formyl-THF
PRS5
ATP
IMD2
xanthosine-5-phosphate
dGDP
phosphate
ATP
URA8
phosphate
L-glutamate
ADP
ADP
URA6
phosphate
2 ADP
RNR2
L-glycine
ATP
GDP
L-glutamate
L-glutamine
ADE17
GMP
HIS3
ATP
ATP
pyrophosphate
RNR3
ATP
PRPP
YNK1
PRS4
ADP
D-ribose-5-phosphate
ADE5,7
phosphate
HIS4
ADP
URA4
IMD3
NADH
ATP
GTP
L-glutamine
HIS1
URA2
10-formyl-THF
L-glutamate
L-glutamate
phosphate
ADP
NADH
ADE16
L-glutamate
ATP
ATP
L-glutamine
ADE17
ADE5,7
ADP
ADE16
pyrophosphate
L-histidine
ATP
AICAR
URA5
ATP
HIS4
PRS3
L-glutamine
ATP
2 ATP
ADP
URA7
ADE6
URA2
YNK1
ATP
phosphate
pyrophosphate
URA1
URA10
ADP
ATP
ADP
RNR4
ADP
ADE2
URA3
L-glutamine
HIS2
L-glutamate
pyrophosphate
phosphate
L-glutamate
RNR1
PRS1
phosphate
ADE4
Description
No description
Comments
GenMAPP remarks
Based on
http://pathway.yeastgenome.org/biocyc/
Try the New WikiPathways
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
''Histidine, purine, and pyrimidine superpathway''; YeastPathways,
History
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Compare
Revision
Action
Time
User
Comment
135544
view
20:00, 23 September 2024
Khanspers
Modified description
135448
view
21:58, 5 September 2024
Khanspers
Ontology Term : 'classic metabolic pathway' added !
135447
view
21:58, 5 September 2024
Khanspers
removed GenMAPP comments
135446
view
21:57, 5 September 2024
Khanspers
135445
view
21:56, 5 September 2024
Khanspers
lit ref
135314
view
00:05, 17 August 2024
Khanspers
interactions
122754
view
05:17, 10 May 2022
Egonw
Added identifiers to water nodes
117345
view
11:53, 20 May 2021
Eweitz
Modified title
107259
view
14:35, 17 September 2019
MaintBot
ChEBI identifier normalization
94664
view
13:18, 4 October 2017
DeSl
Changed ribose-5-P label to D-ribose-5-P
94663
view
13:17, 4 October 2017
DeSl
Connected all lines, changed all textlabels to metabolite nodes, connected all genes to the lines.
93079
view
09:22, 28 July 2017
Elisa
Fixed some of the unconnected interactions (left side of the pathway).
93011
view
14:46, 24 July 2017
DeSl
Changed wrong CAS number (salt) for correct ChEBI ID
85638
view
16:11, 4 June 2016
Egonw
Fixed the CAS number.
71897
view
10:35, 22 October 2013
Mkutmon
changed AICAR from Unknown to Metabolite
70270
view
21:50, 15 July 2013
MaintBot
updated to 2013 schema
69872
view
18:00, 11 July 2013
Egonw
Marked a few DataNodes with CAS registry numbers as metabolites.
67670
view
11:47, 26 June 2013
Ddigles
Ontology Term : 'nucleotide metabolic pathway' added !
41803
view
04:48, 2 March 2011
MaintBot
Removed redundant pathway information and comments
21558
view
11:32, 14 November 2008
MaintBot
[[Pathway:Saccharomyces cerevisiae:Superpathway of Histidine Purine and Pyrimidine Biosynthesis]] moved to [[Pathway:WP416]]: Moved to stable identifier
12861
view
08:06, 17 May 2008
MaintBot
automated metabolite conversion
8948
view
14:13, 7 January 2008
MaintBot
Added to category $category
8946
view
14:13, 7 January 2008
M.Braymer
Uploaded new pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
10-formyl-THF
Metabolite
2800-34-2 (CAS)
2 ADP
Metabolite
58-64-0 (CAS)
2 ATP
Metabolite
1927-31-7 (CAS)
2-oxoglutarate
Metabolite
5-phospho-ribosyl-glycineamide
Metabolite
5-phosphoribosyl-n-formylglycineamidine
Metabolite
5-phosphoribosylamine
Metabolite
5’-phosphoribosyl-4-(N-
Metabolite
5’-phosphoribosyl-5-aminoimidazole
Metabolite
5’-phosphoribosyl-N-formylglycineamide
Metabolite
ADE13
GeneProduct
S000004351 (SGD)
ADE16
GeneProduct
S000004018 (SGD)
ADE17
GeneProduct
S000004727 (SGD)
ADE1
GeneProduct
S000000070 (SGD)
ADE2
GeneProduct
S000005654 (SGD)
ADE4
GeneProduct
S000004915 (SGD)
ADE5,7
GeneProduct
S000003203 (SGD)
ADE6
GeneProduct
S000003293 (SGD)
ADE8
GeneProduct
S000002816 (SGD)
ADP
Metabolite
58-64-0 (CAS)
AICAR
Metabolite
3031-94-5 (CAS)
AMP
Metabolite
ATP
Metabolite
1927-31-7 (CAS)
CDP
Metabolite
63-38-7 (CAS)
CO2
Metabolite
CTP
Metabolite
D-erythro-imidazole-glycerol-phosphate
Metabolite
D-ribose-5-phosphate
Metabolite
3615-55-2 (CAS)
GDP
Metabolite
146-91-8 (CAS)
GMP
Metabolite
85-32-5 (CAS)
GTP
Metabolite
2564-35-4 (CAS)
GUA1
GeneProduct
S000004830 (SGD)
GUK1
GeneProduct
S000001550 (SGD)
H+
Metabolite
H2O
Metabolite
HCO3
Metabolite
HIS1
GeneProduct
S000000857 (SGD)
HIS2
GeneProduct
S000001921 (SGD)
HIS3
GeneProduct
S000005728 (SGD)
HIS4
GeneProduct
S000000535 (SGD)
HIS5
GeneProduct
S000001378 (SGD)
HIS6
GeneProduct
S000001282 (SGD)
IMD2
GeneProduct
S000001259 (SGD)
IMD3
GeneProduct
S000004424 (SGD)
IMD4
GeneProduct
S000004520 (SGD)
IMP
Metabolite
L-aspartate
Metabolite
L-glutamate
Metabolite
56-86-0 (CAS)
L-glutamine
Metabolite
56-85-9 (CAS)
L-glycine
Metabolite
56-40-6 (CAS)
L-histidine
Metabolite
71-00-1 (CAS)
L-histidinol-phosphate
Metabolite
25679-93-0 (CAS)
NAD
Metabolite
NADH
Metabolite
53-84-9 (CAS)
NH3
Metabolite
PRPP
Metabolite
97-55-2 (CAS)
PRS1
GeneProduct
S000001664 (SGD)
PRS2
GeneProduct
S000000901 (SGD)
PRS3
GeneProduct
S000001003 (SGD)
PRS4
GeneProduct
S000000164 (SGD)
PRS5
GeneProduct
S000005422 (SGD)
RNR1
GeneProduct
S000000872 (SGD)
RNR2
GeneProduct
S000003563 (SGD)
RNR3
GeneProduct
S000001328 (SGD)
RNR4
GeneProduct
S000003412 (SGD)
THF
Metabolite
UDP
Metabolite
UMP
Metabolite
URA10
GeneProduct
S000004884 (SGD)
URA1
GeneProduct
S000001699 (SGD)
URA2
GeneProduct
S000003666 (SGD)
URA3
GeneProduct
S000000747 (SGD)
URA4
GeneProduct
S000004412 (SGD)
URA5
GeneProduct
S000004574 (SGD)
URA6
GeneProduct
S000001507 (SGD)
URA7
GeneProduct
S000000135 (SGD)
URA8
GeneProduct
S000003864 (SGD)
UTP
Metabolite
YNK1
GeneProduct
S000001550 (SGD)
carbamoyl-L-aspartate
Metabolite
carbamoyl-phosphate
Metabolite
dGDP
Metabolite
28862 (ChEBI)
deoxy-GTP
Metabolite
dihydroorotate
Metabolite
fumerate
Metabolite
histidinal
Metabolite
histidinol
Metabolite
imidazole acetol-phosphate
Metabolite
orotate
Metabolite
orotidine-5’-phosphate
Metabolite
oxidized flavodoxin
Metabolite
oxidized thioredoxin
Metabolite
phosphate
Metabolite
14265-44-2 (CAS)
phosphoribosyl-AMP
Metabolite
phosphoribosyl-ATP
Metabolite
phosphoribosyl-carboxy-aminoimidazole
Metabolite
phosphoribosyl-formamido-carboxamide
Metabolite
phosphoribosylformiminoAICAR-phosphate
Metabolite
phosphoribulosylformimino-AICAR-P
Metabolite
pyrophosphate
Metabolite
2466-09-3 (CAS)
reduced flavodoxin
Metabolite
reduced thioredoxin
Metabolite
sucinocarboxamide)-5-aminoimidazole
Metabolite
xanthosine-5-phosphate
Metabolite
523-98-8 (CAS)
Annotated Interactions
No annotated interactions
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Annotated Interactions
No annotated interactions