Lidocaine metabolism (Homo sapiens)

From WikiPathways

Revision as of 00:13, 13 October 2017 by Khanspers (Talk | contribs)
Jump to: navigation, search
1, 21-33-hydroxylidocaineCYP1A22,6-xylidine2-amino-3-methylbenzoatemonoethylglycinexylidide4-hydroxy-2,6-dimethylaniline3-hydroxymonoethylglycinexylidideLidocaineCYP3A4glycinexylidideCYP1A2CYP3A4


Description

Lidocaine is primarily metabolized by CYP1A2 but minor involvement of CYP3A4 is observed too. Based on KEGG

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Isohanni MH, Neuvonen PJ, Olkkola KT; ''Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.''; Basic Clin Pharmacol Toxicol, 2006 PubMed Europe PMC Scholia
  2. Wang JS, Backman JT, Wen X, Taavitsainen P, Neuvonen PJ, Kivistö KT; ''Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.''; Pharmacol Toxicol, 1999 PubMed Europe PMC Scholia
  3. Orlando R, Piccoli P, De Martin S, Padrini R, Floreani M, Palatini P; ''Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.''; Clin Pharmacol Ther, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106722view13:16, 17 September 2019MaintBotHMDB identifier normalization
94915view00:13, 13 October 2017Khanspersmoved link to KEGG
94737view15:03, 5 October 2017EgonwAdded a missing mim-type.
92384view18:19, 31 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
74430view15:48, 18 April 2014EgonwAdded a third reference.
74429view15:47, 18 April 2014EgonwModified description
74428view15:43, 18 April 2014EgonwAdded two literature references.
74427view15:36, 18 April 2014EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
74424view15:33, 18 April 2014EgonwRemoved a redundant (empty) comment.
74423view15:32, 18 April 2014EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2,6-xylidineMetaboliteCHEBI:28738 (ChEBI)
2-amino-3-methylbenzoateMetabolite4161142 (PubChem-compound)
3-hydroxylidocaineMetabolite161824 (PubChem-compound)
3-hydroxymonoethyl glycinexylidideMetaboliteC16572 (KEGG Compound)
4-hydroxy- 2,6-dimethylanilineMetaboliteCHEBI:55545 (ChEBI)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
LidocaineMetaboliteHMDB14426 (HMDB)
glycinexylidideMetaboliteCHEBI:357241 (ChEBI)
monoethyl glycinexylidideMetabolite24415 (PubChem-compound)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2646"
Personal tools