Diet-induced obesity inflammation-induced microvascular insulin resistance (Rattus norvegicus)
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Description
Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. Salicylate treatment fully inhibited vascular inflammation, prevented microvascular insulin resistance and significantly improved muscle metabolic responses to insulin. Insulin resistance and inflammation play an essential role in the process of microvascular insuline resistance. This study was performed on rats; a (+) or (-) indicates a change in regulation, due to high fat diet induced diabetes mellitus.
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Saving...Bibliography
- Zhao L, Fu Z, Wu J, Aylor KW, Barrett EJ, Cao W, Liu Z; ''Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity.''; Clin Sci (Lond), 2015 PubMed Europe PMC Scholia
- Jonk AM, Houben AJ, de Jongh RT, Serné EH, Schaper NC, Stehouwer CD; ''Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension.''; Physiology (Bethesda), 2007 PubMed Europe PMC Scholia
- Muris DM, Houben AJ, Schram MT, Stehouwer CD; ''Microvascular dysfunction: an emerging pathway in the pathogenesis of obesity-related insulin resistance.''; Rev Endocr Metab Disord, 2013 PubMed Europe PMC Scholia
- Houben AJHM, Martens RJH, Stehouwer CDA; ''Assessing Microvascular Function in Humans from a Chronic Disease Perspective.''; J Am Soc Nephrol, 2017 PubMed Europe PMC Scholia
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AKT | GeneProduct | Q24371776 (Wikidata)  | AKT serine/threonine kinase 1 |
| AP-1 (+) | GeneProduct | Q24383897 (Wikidata) | Jun proto-oncogene, AP-1 |
| AT II (+) | Protein | Q28560159 (Wikidata) | Angiotensin II receptor, type 2 |
| CAMS (KAM-1) | |||
| CAMS (KAM-1) (+) | |||
| Chemokinase (MCP-1) | |||
| Cytokinase (K-1) | |||
| Diabetis Mellitus (type 2) | 125853 (OMIM) | DISEASE | |
| ET 1 (+) | GeneProduct | Q24406343 (Wikidata) | Et1= endothelin 1 |
| Hyperglycemmia | 6234 (Other) | Database=http://www.diseasesdatabase.com/ddb6234.htm | |
| Hypertension | |||
| Inflammation | |||
| Inflammation PW | Pathway | WP40 (WikiPathways) | |
| Insulin | Metabolite | Q39798 (Wikidata) | |
| Insuline resistance | |||
| JNK | GeneProduct | Q24408169 (Wikidata) | |
| NFkB (+) | Protein | G8ZCS7 (Uniprot-TrEMBL) | nuclear factor kappa-light-chain-enhancer of activated B cells |
| NO (-) | Metabolite | Q207843 (Wikidata) | nitric oxide |
| PA 1 (+) | GeneProduct | Q24395829 (Wikidata) | Paxip1-associated glutamate-rich protein 1 |
| Peripheral resistance (+) | |||
| Protein Kinase C | Protein | 2.7.11.13 (Enzyme Nomenclature) | |
| RAGE PW | Pathway | WP2324 (WikiPathways) | |
| RAGE | Protein | 177 (Entrez Gene) | |
| ROS | Metabolite | Q424361 (Wikidata) | |
| Salicylate treatment | Metabolite | Q27104145 (Wikidata) | |
| TF (+) | GeneProduct | Q24370087 (Wikidata) | Transferrin |
| TLRs | Protein | Q408004 (Wikidata) | Toll-like receptors |
| TNFalpha | Protein | 24835 (Entrez Gene) | Tumor necrosis factor alpha |
| Thrombosis | 188055 (OMIM) | DISEASE | |
| VSMC growth | |||
| Vasoconstriction | |||
| Vasodilation (-) | Symptom | ||
| eNOS (-) | Protein | Q24382816 (Wikidata) | nitric oxide synthase 3 |
| endothelial dysfunction | |||
| free fatty acids (tryglycerides) | Metabolite | CHEBI:35366 (ChEBI) | |
| hypercoagulation | |||
| hyperinsulinemia | Symptom | ||
| insuline resistence (+) | |||
| insuline uptake (-) | |||
| organ dysfunction | |||
| oxidative stress | Pathway | WP173 (WikiPathways) | |
| platelet activation | |||
| stress | |||
| symapatic nervous system |
Annotated Interactions
No annotated interactions
