Histidine metabolism (Mycobacterium tuberculosis)

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hisDL-histidinol-PL-HistidinePhosphoribulosyl-formimino-AICAR-phosphateD-erythro-Imidazole-glycerol phosphateCobCL-histidinalN-MethylhistaminehisC1histidinol-phosphataseL-histidinolMethylimidazole acetaldehydePhosphoribosyl-formimino-AICAR-phosphateS-(Hercyn-2-yl)-L-cysteine S-oxidegamma-glutamyl hercynylcysteine S-oxide hydrolase ErgothioneineaofHhisFhisHL-histidine N alpha-methyltransferasehisEImidazole-acetol phosphate5-Phosphoribosyl diphosphateHercyninealdehyde dehydrogenase (NAD+)Imidazole-4-acetatehisGgamma-L-Glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxidehisC2hercynylcysteine S-oxide lyasePhosphoribosyl-AMPPentose phosphate pathwayhisIhisAgamma-glutamyl hercynylcysteine S-oxide synthase hisBPhosphoribosyl-ATPImidazole-4-acetaldehydeThiourocanic acid


Description

Source: KEGG Pathways

Mycobacterium tuberculosis is an obligate pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. This coating makes the cells impervious to Gram staining, and as a result, M. tuberculosis can appear either Gram-negative or Gram-positive.

Several of the proteins needed for hystidine metabolism are not present in Mycobacterium tuberculosis, resulting in incomplete knowledge on the formation of for example imidazole-4-acetaldehyde and N-methylhistamine.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
134124view23:10, 28 June 2024Khanspersupdate board height
115241view08:29, 7 February 2021EgonwMade one more pathway clickable
101920view13:15, 17 November 2018EgonwReplaced old Uniprot data sources with the new ones.
95555view13:44, 27 December 2017DeSlRemoved licence number
95427view16:25, 14 December 2017DeSlOntology Term : 'Mycobacterium tuberculosis infection pathway' added !
95426view16:24, 14 December 2017DeSlModified description
95425view16:23, 14 December 2017DeSlModified description
95424view16:19, 14 December 2017DeSlRemoved all faulty IDs (KEGG orthologs), exchanged with ECnumbers. Added missing metabolites, removed the ones which could not be present biologically. Changed layout. Changged arrows to correct MIM type. Connected all enzymes accordingly.
77717view17:05, 15 October 2014EgonwReplaced 'Kegg enzyme' (not in recent BridgeDb versions) with 'Enzyme Nomenclature'.
72095view21:36, 24 October 2013Mkutmonadded datasource for "Purin metabolism"
71650view19:34, 17 October 2013MaintBotAutomated update of data sources
69571view20:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
67338view10:39, 26 June 2013Christine ChichesterOntology Term : 'histidine metabolic pathway' added !
41507view01:12, 2 March 2011MaintBotRemoved redundant pathway information and comments
40071view03:27, 6 February 2011AlexanderPicocurated edges
38996view19:41, 25 September 2010AlexanderPicoModified description
38995view19:41, 25 September 2010AlexanderPico
38994view19:40, 25 September 2010AlexanderPicofixed lines, groups and pathway nodes; refactored layout a bit
38630view21:06, 22 September 2010AllanKuchinskymoved EC:2.1.1.- to a straight line
38613view00:52, 22 September 2010AllanKuchinskyremoved spurious enzyme family -- ajk
38212view23:25, 26 August 2010KhanspersChanged xrefs
38211view23:08, 26 August 2010KhanspersChanged xrefs
37736view21:35, 29 June 2010KhanspersModified categories
37735view19:18, 29 June 2010KhanspersRemoved group
37734view19:16, 29 June 2010KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5-Phosphoribosyl diphosphateMetaboliteC00119 (KEGG Compound)
CobCProteinP9WQ89 (Uniprot-SwissProt)
D-erythro-Imidazole-glycerol phosphateMetaboliteC04666 (KEGG Compound)
ErgothioneineMetaboliteC05570 (KEGG Compound)
HercynineMetaboliteC05575 (KEGG Compound)
Imidazole-4-acetaldehydeMetaboliteC05130 (KEGG Compound)
Imidazole-4-acetateMetaboliteC02835 (KEGG Compound)
Imidazole-acetol phosphateMetaboliteC01267 (KEGG Compound)
L-HistidineMetaboliteC00135 (KEGG Compound)
L-histidinalMetaboliteC01929 (KEGG Compound)
L-histidine

N alpha-

methyltransferase		Protein2.1.1.44 (Enzyme Nomenclature)
L-histidinol-PMetaboliteC01100 (KEGG Compound)
L-histidinolMetaboliteC00860 (KEGG Compound)
Methylimidazole acetaldehydeMetaboliteC05827 (KEGG Compound)
N-MethylhistamineMetaboliteC05127 (KEGG Compound)
Pentose phosphate pathwayPathwayWP1684 (WikiPathways)
Phosphoribosyl-AMPMetaboliteC02741 (KEGG Compound)
Phosphoribosyl-ATPMetaboliteC02739 (KEGG Compound)
Phosphoribosyl-formimino-AICAR-phosphateMetaboliteC04896 (KEGG Compound)
Phosphoribulosyl-formimino-AICAR-phosphateMetaboliteC04916 (KEGG Compound)
S-(Hercyn-2-yl)- L-cysteine S-oxideMetaboliteC20994 (KEGG Compound)
Thiourocanic acidMetaboliteC05571 (KEGG Compound)
aldehyde dehydrogenase (NAD+)GeneProduct1.2.1.3 (Enzyme Nomenclature) Original kegg element: gene;19;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aofHGeneProduct1.4.3.4 (Enzyme Nomenclature) Original kegg element: gene;20;mtu:Rv3170
gamma-L-Glutamyl-

S-(hercyn-2-yl)-

L-cysteine S-oxide		MetaboliteC20995 (KEGG Compound)
gamma-glutamyl

hercynylcysteine

S-oxide hydrolase 		Protein3.5.1.1.18 (Enzyme Nomenclature)
gamma-glutamyl

hercynylcysteine

S-oxide synthase 		Protein1.1.499.50 (Enzyme Nomenclature)
hercynylcysteine S-oxide lyaseProtein4.4.1.36 (Enzyme Nomenclature)
hisAGeneProduct5.3.1.16 (Enzyme Nomenclature) Original kegg element: gene;32;mtu:Rv1603
hisBGeneProductRv1601 (TubercuList) Original kegg element: gene;30;mtu:Rv1601
hisC1GeneProductI6XYD8 (Uniprot-SwissProt) Original kegg element: gene;29;mtu:Rv1600 mtu:Rv3772
hisC2GeneProductI6Y4H4 (Uniprot-SwissProt) Original kegg element: gene;29;mtu:Rv1600 mtu:Rv3772
hisDGeneProduct1.1.1.23 (Enzyme Nomenclature) Original kegg element: gene;27;mtu:Rv1599
hisEGeneProduct3.6.1.31 (Enzyme Nomenclature) Original kegg element: gene;34;mtu:Rv2122c
hisFGeneProductI6XYE3 (Uniprot-SwissProt) Original kegg element: gene;36;mtu:Rv1605
hisGGeneProduct2.4.2.17 (Enzyme Nomenclature) Original kegg element: gene;25;mtu:Rv2121c
hisHGeneProductI6YB19 (Uniprot-TrEMBL) Original kegg element: gene;91;mtu:Rv1602
hisIGeneProduct3.5.4.19 (Enzyme Nomenclature) Original kegg element: gene;33;mtu:Rv1606
histidinol- phosphataseGeneProduct3.1.3.15 (Enzyme Nomenclature)

Annotated Interactions

No annotated interactions

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