Glycerol teichoic acid biosynthesis (Saccharomyces cerevisiae)

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1, 2peptidoglycanUDP-acetylmannosamineundecaprenyl phosphateundecanyl-diphospho-GlcNAcGlycerol-3-phosphateUMPUDP-D-glucoseCMPpeptidoglycan-GlcNAc-ManNAc-(P-Gol)3(P-Gol-Glc)mCTPundecaprenyl phosphateUDP-Acetyl-D-glucosamineUDPundecanyl-diphospho-GlcNAcManNAc-(P-Gol)3undecanyl-diphospho-GlcNAc-ManNAc-(P-Gol)3(P-Gol-Glc)nundecanyl-diphospho-GlcNAc-ManNAc-(P-Gol)3(P-Gol-Glc)1UDPUTP3 CMPundecanyl-diphospho-GlcNAc-ManNAc-(P-Gol)3(P-Gol)n+1(Glc)n3 CDPglycerolundecanyl-diphospho-GlcNAc-ManNAcCDPglycerolglucose-1-phosphateUGP1glucose-6-phosphatePGM1pyrophosphateYHL012WPGM2


Description

The peptidoglycan layers of many gram-positive bacteria (such as Saccharomyces cerevisiae) are densely functionalized with anionic glycopolymers called wall teichoic acids (WTAs). These polymers play crucial roles in cell shape determination, regulation of cell division, and other fundamental aspects of gram-positive bacterial physiology. Additionally, WTAs are important in pathogenesis and play key roles in antibiotic resistance. Based on http://pathway.yeastgenome.org/biocyc/

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Quality Tags

Ontology Terms

 

Bibliography

  1. Swoboda, J. G., Campbell, J., Meredith, T. C., Walker, S.; ''Wall teichoic acid function, biosynthesis, and inhibition.''; Chembiochem, 2010 PubMed Europe PMC Scholia
  2. Brown S, Santa Maria JP Jr, Walker S; ''Wall teichoic acids of gram-positive bacteria.''; Annu Rev Microbiol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125335view22:32, 31 January 2023LarsgwAdd PMID to reference
117298view11:16, 20 May 2021EweitzModified title
96357view17:22, 9 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95624view23:16, 10 January 2018Khanspersremoved GenMAPP comment
95383view10:49, 11 December 2017DeSlAdded wikidata as database source where applicable
95382view10:47, 11 December 2017DeSlAdded additional identifiers for metabolites.
95381view09:29, 11 December 2017DeSlAdded wikidata as database source where applicable
95380view09:27, 11 December 2017DeSlModified description
95379view09:27, 11 December 2017DeSlAdded additional literature reference, connected unconnected lines.
95378view09:20, 11 December 2017DeSlAdded lit. ref, annotated several nodes, integrated PW elements with each other.
94158view14:01, 24 August 2017DeSlChanged all text labels into datanodes. I cannot do anything with this PW further, since I cannot find the proper source.
87559view02:17, 25 July 2016AlexanderPicoOntology Term : 'classic metabolic pathway' added !
70042view05:50, 12 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69629view20:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
41864view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
21866view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Glycerol Teichoic Acid Biosynthesis]] moved to [[Pathway:WP563]]: Moved to stable identifier
12728view08:00, 17 May 2008MaintBotautomated metabolite conversion
8753view14:08, 7 January 2008MaintBotAdded to category $category
8751view14:08, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3 CDPglycerolMetaboliteQ27102700 (Wikidata)
3 CMPMetaboliteQ412622 (Wikidata) Cytidine monophosphate
CDPglycerolMetaboliteQ27102700 (Wikidata) Cytidine diphosphate-glycerol
CMPMetaboliteQ412622 (Wikidata) Cytidine monophosphate
CTPMetaboliteCHEBI:3285 (ChEBI) Cytidine triphosphate
Glycerol-3-phosphateMetaboliteCHEBI:10648 (ChEBI)
PGM1GeneProductS000001610 (SGD)
PGM2GeneProductS000004711 (SGD)
UDP-Acetyl-D-glucosamineMetaboliteCHEBI:16264 (ChEBI)
UDP-D-glucoseMetaboliteCHEBI:52249 (ChEBI)
UDP-acetylmannosamineMetaboliteCHEBI:68678 (ChEBI)
UDPMetaboliteQ412593 (Wikidata)
UGP1GeneProductS000001518 (SGD)
UMPMetaboliteQ27074278 (Wikidata) 5'UMP
UTPMetaboliteCHEBI:15713 (ChEBI) 5'-UTP
YHL012WGeneProductS000001004 (SGD)
glucose-1-phosphateMetaboliteQ27098367 (Wikidata) Assuming closed form
glucose-6-phosphateMetabolite59-56-3 (CAS)
peptidoglycanMetabolite
peptidoglycan-GlcNAc-ManNAc-(P-Gol)3(P-Gol-Glc)mMetabolite
pyrophosphateMetabolite2466-09-3 (CAS)
undecanyl-diphospho-GlcNAc-ManNAcMetaboliteUDP-glucosamine-mannosamine?
undecanyl-diphospho-GlcNAc-ManNAc-(P-Gol)3(P-Gol)n+1(Glc)nMetabolite
undecanyl-diphospho-GlcNAc-ManNAc-(P-Gol)3(P-Gol-Glc)1Metabolite
undecanyl-diphospho-GlcNAc-ManNAc-(P-Gol)3(P-Gol-Glc)nMetabolite
undecanyl-diphospho-GlcNAcManNAc-(P-Gol)3Metabolite
undecanyl-diphospho-GlcNAcMetaboliteQ312208 (Wikidata) UDP-GlcNAc aka UDP N-acetyl-glucosamine
undecaprenyl phosphateMetaboliteCHEBI:27193 (ChEBI)

Annotated Interactions

No annotated interactions

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