CRD motif and sFRPs influence on Wnt signaling (Danio rerio)
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Legend:
Activation by N-terminal CRD motif
Endocytosis
Enhanced
signaling
JNK
Fz7 receptor
papc
sFRP2
distinct non-canonical
Wnt pathways
RhoA
Fz7a
Fz7 receptor
Ror2 receptor
Wnt5a
JNK
sFRP2
Ror2
Fz7 receptor
Ror2 receptor
distinct non-canonical
Wnt pathways
Activation by extracellular CRD motif
Endocytosis
Fz7b
distinct non-canonical
Wnt pathways
JNK
papc
papc
papc
papc
papc
papc
Endocytosis
Description
New PW on Danio rerio signaling
Comments
Study conducted on wild-type zebrafish AB2O3.
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Bibliography
Brinkmann EM, Mattes B, Kumar R, Hagemann AI, Gradl D, Scholpp S, Steinbeisser H, Kaufmann LT, Özbek S; ''Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation.''; J Biol Chem, 2016
PubMed
Europe PMC
Scholia
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Comment
96496
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21:34, 15 March 2018
DeSl
Changed gene node to textlabel where needed, slight modification of title.
96495
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21:32, 15 March 2018
DeSl
Added more IDs
96494
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21:16, 15 March 2018
DeSl
Ontology Term : 'embryonic stem cell' added !
96492
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21:11, 15 March 2018
DeSl
Ontology Term : 'Wnt signaling pathway' added !
96491
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21:11, 15 March 2018
DeSl
Modified description
96489
view
21:08, 15 March 2018
DeSl
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
Fz7 receptor
Protein
Fz7a
GeneProduct
ENSDARG00000060004 (Ensembl)
Fz7b
GeneProduct
ENSDARG00000027589 (Ensembl)
JNK
Protein
RhoA
Protein
Ror2
Protein
Ror2 receptor
Protein
Wnt5a
Protein
distinct non-canonical Wnt pathways
Pathway
papc
Protein
sFRP2
Protein
Annotated Interactions
No annotated interactions
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Pathway
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No annotated interactions