MET in type 1 papillary renal cell carcinoma (Homo sapiens)

From WikiPathways

Revision as of 18:10, 23 March 2018 by Khanspers (Talk | contribs)
Jump to: navigation, search
1-6, 8-1315141515151514NucleusEpithelial cell of proximal renal tubuleEndothelial cellGene fusionsSurvivalInvasionCell junctionNegative MetregulationCell polarityActin cytoskeletonMotilityMigrationSTAT3HGFforetinibPTPsPKCMAPK8VEGFCBLPLCG1VEGFRPIK3CAPIP3METGAB1PGRB2SOS1SOS2HRASKRASNRASCRKCRKLRAPGEF1PTPN11RAP1ARAP1BARAFRAF1BRAFRAC1CDC42PAK4BUB1B-PAK6PAK1PAK2PAK3PAK6PAK5MAP2K1PMAP2K2PPPMAPK1PMAPK3PPPPIK3CBPIK3CDPIK3R1PIK3R2PIK3R3PIK3R3AKT1AKT2AKT3BADETS1PPJUNPCell cycle progressionProliferationTFE3PRCCCDKN1ATFE3SFPQTFE3DVL2TFE3RBM10CTSKBIRC7DIAPH1HIF1ACTSKTFEBTFEBCOL21A1CADM27tivantinibCRKTransformationPTK2SRCDAGIP3Ca2+


Description

No description

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Mills Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, DeVolk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, McMeekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna R; ''Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.''; N Engl J Med, 2016 PubMed Europe PMC Scholia
  2. Giubellino A, Linehan WM, Bottaro DP; ''Targeting the Met signaling pathway in renal cancer.''; Expert Rev Anticancer Ther, 2009 PubMed Europe PMC Scholia
  3. Fay AP, Signoretti S, Choueiri TK; ''MET as a target in papillary renal cell carcinoma.''; Clin Cancer Res, 2014 PubMed Europe PMC Scholia
  4. Furge KA, Zhang YW, Vande Woude GF; ''Met receptor tyrosine kinase: enhanced signaling through adapter proteins.''; Oncogene, 2000 PubMed Europe PMC Scholia
  5. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia
  6. Appleman LJ; ''MET signaling pathway: a rational target for cancer therapy.''; J Clin Oncol, 2011 PubMed Europe PMC Scholia
  7. Cecchi F, Rabe DC, Bottaro DP; ''Targeting the HGF/Met signalling pathway in cancer.''; Eur J Cancer, 2010 PubMed Europe PMC Scholia
  8. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129356view09:32, 27 March 2024MkutmonOntology Term : 'cancer pathway' added !
129355view09:32, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
127242view00:24, 26 August 2023Khanspersadded lit ref and updated description
118937view22:26, 4 June 2021EweitzOntology Term : 'epithelial cell' added !
118936view22:26, 4 June 2021EweitzOntology Term : 'endothelial cell' added !
118928view16:33, 4 June 2021Finterlyspelling siregrpid corrected to sitegrpid in state comments
118432view14:35, 27 May 2021Mkutmonfixed publication references
112059view21:58, 17 September 2020KhanspersModified description
112057view21:53, 17 September 2020Khanspersupdated and added ptms
112056view21:08, 17 September 2020KhanspersModified description
112055view20:54, 17 September 2020KhanspersOntology Term : 'cancer' added !
112054view20:53, 17 September 2020KhanspersOntology Term : 'papillary renal cell carcinoma' added !
105480view05:37, 8 August 2019KhanspersModified description
105443view04:54, 8 August 2019KhanspersModified description
97130view19:00, 30 April 2018Khanspersupdated lit refs, updated connections
96851view19:39, 13 April 2018Khansperscorrected placement of states
96632view22:47, 23 March 2018Khanspersupdated Chebi ids
96629view19:28, 23 March 2018Khanspersupdating gene fusions
96628view18:11, 23 March 2018KhanspersModified description
96627view18:10, 23 March 2018Khanspersupdated phosphosites and mutations
96452view09:31, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96109view00:16, 17 February 2018KhanspersModified title
96011view11:14, 15 February 2018DdiglesOntology Term : 'malignant cell' added !
95923view18:14, 5 February 2018Khanspersfixed unconnected
95850view22:02, 25 January 2018Khanspersadded Appleman ref
95849view22:00, 25 January 2018KhanspersModified title
95848view21:59, 25 January 2018KhanspersOntology Term : 'altered scatter factor/hepatocyte growth factor signaling pathway' added !
95847view21:58, 25 January 2018KhanspersOntology Term : 'papillary renal cell carcinoma' added !
95845view21:55, 25 January 2018Khanspersfixed unconnected
95824view21:51, 23 January 2018KhanspersModified description
95823view21:48, 23 January 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BIRC7GeneProductENSG00000101197 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
BUB1B-PAK6GeneProductENSG00000259288 (Ensembl)
CADM2GeneProductENSG00000175161 (Ensembl)
CBLGeneProductENSG00000110395 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
COL21A1GeneProductENSG00000124749 (Ensembl)
CRKGeneProductENSG00000167193 (Ensembl)
CRKLGeneProductENSG00000099942 (Ensembl)
CTSKGeneProductENSG00000143387 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
DAGMetaboliteCHEBI:4481 (ChEBI)
DIAPH1GeneProductENSG00000131504 (Ensembl)
DVL2GeneProductENSG00000004975 (Ensembl)
ETS1GeneProductENSG00000134954 (Ensembl)
GAB1GeneProductENSG00000109458 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IP3MetaboliteCHEBI:84244 (ChEBI)
JUNGeneProductENSG00000177606 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
METGeneProduct4233 (Entrez Gene)
NRASGeneProductENSG00000213281 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PAK2GeneProductENSG00000180370 (Ensembl)
PAK3GeneProductENSG00000077264 (Ensembl)
PAK4GeneProductENSG00000130669 (Ensembl)
PAK5GeneProductENSG00000101349 (Ensembl)
PAK6GeneProductENSG00000137843 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PKCGeneProduct
PLCG1GeneProductENSG00000124181 (Ensembl)
PRCCGeneProductENSG00000143294 (Ensembl)
PTK2GeneProductENSG00000169398 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
PTPsGeneProduct
RAC1GeneProductENSG00000136238 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
RAP1BGeneProductENSG00000127314 (Ensembl)
RAPGEF1GeneProductENSG00000107263 (Ensembl)
RBM10GeneProductENSG00000182872 (Ensembl)
SFPQGeneProductENSG00000116560 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TFE3GeneProductENSG00000068323 (Ensembl)
TFEBGeneProductENSG00000112561 (Ensembl)
VEGFGeneProduct
VEGFRGeneProduct
foretinibMetaboliteQ5469311 (Wikidata)
tivantinibMetaboliteQ17123902 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4205"
Personal tools