Heterochronic gene regulation of development (Caenorhabditis elegans)
From WikiPathways
Description
The heterochronic pathway, regulating larval development in Caenorhabditis elegans, is shown.
Heterochronic is associated with the development of cells or tissues at a "different" time relative to other developmental events. Changes in developmental timing are thought to be a driving force of morphological evolution.
Regulatory relationships shown here are supported by genetic data, but not all are direct. Lin-42 is not shown, as its complex expression pattern and genetic interactions suggest that it acts at multiple steps through out the pathways, making its precise placement difficult. In the absence of ligand DAF-12 represses let-7 family miRNAs.
Arrows indicate activation - Bars indicate repression.Quality Tags
Ontology Terms
Saving...Bibliography
- Resnick TD, McCulloch KA, Rougvie AE; ''miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans.''; Dev Dyn, 2010 PubMed Europe PMC Scholia
- Moss EG; ''Heterochronic genes and the nature of developmental time.''; Curr Biol, 2007 PubMed Europe PMC Scholia
- Abbott AL; ''Heterochronic genes.''; Curr Biol, 2003 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| DAF-12 | GeneProduct | F11A1.3 (WormBase)  | |
| HBL-1 | GeneProduct | F13D11.2 (WormBase) | |
| LIN-14 | GeneProduct | T25C12.1 (WormBase) | |
| LIN-28 | GeneProduct | F02E9.2 (WormBase) | |
| LIN-29 | GeneProduct | W03C9.4 (WormBase) | |
| LIN-41 | GeneProduct | C12C8.3 (WormBase) | |
| LIN-46 | GeneProduct | R186.4 (WormBase) | |
| LIN-66 | GeneProduct | B0513.1 (WormBase) | |
| let-7 | Rna | C05G5.6 (WormBase) | |
| lin-4 | Rna | F59G1.6 (WormBase) | |
| mir-241 | Rna | F56A12.4 (WormBase) | |
| mir-48 | Rna | F56A12.3 (WormBase) | |
| mir-84 | Rna | B0395.4 (WormBase) |
Annotated Interactions
No annotated interactions
