Trans-sulfuration pathway (Homo sapiens)

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1DNMT1Creatine3-SulfinopyruvateGGT5LDHCL-CystathionineCKMT1BATPGOT1CSADCKBCreatinine5-Methyl-THFTetrahydrofolate (THF)2-HydroxybutyrateCRATCKMT1APYRUVATEMETABOLISMLDHAL6ADBTSOGAD1CKMT2L-HomocysteineGOT2GCLMPropionylcarnitineL-MethionineSulfiteADPCTHCDO1L-CysteateL-CysteineS-Adenosylhomocysteine (SAH)LDHBMPSTMAT1ALDHAL6BGOT12-Ketobutyric acidGADL1GGT7MDH2MAT2BPhosphocreatineTaurineGCLCPropionyl-CoA3-SulfinoalanineMTRGGT65-Glutamyl TaurineSPONTANOUSMAT2AHypotaurineGlutathioneL-GlutamateGAD2CBSLDHA3-sulfolactateMDH1S-Adenosylmethionine (SAMe)GGT1AHCYCKMCBSPyruvateBAATBCKDHATaurocholateCTHGSSPhosphateDLDBCKDHBDNMT3ADNMT3BDNMT3LAHCYL1AHCYL2BHMT


Description

Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Beger RD, Sun J, Schnackenberg LK.; ''Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity''; doi: 10.1016/j.taap.2009.11.019, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106183view12:08, 16 August 2019MaintBotHMDB identifier normalization
102689view15:32, 19 January 2019FehrhartOntology Term : 'hepatocyte' added !
102688view15:31, 19 January 2019FehrhartOntology Term : 'sulfur metabolic pathway' added !
102572view16:22, 8 January 2019EgonwFixed a KEGG identifier (one too many zeros)
97377view13:39, 12 May 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97373view09:40, 12 May 2018EgonwFixed a faulty data source where the gene ID was a label (of a metabolite, it seems). Fixes RDF loading.
96816view02:50, 10 April 2018Dipa179New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-HydroxybutyrateMetaboliteCHEBI:50613 (ChEBI)
2-Ketobutyric acidMetaboliteCHEBI:30831 (ChEBI)
3-SulfinoalanineMetaboliteHMDB00996 (HMDB)
3-SulfinopyruvateMetaboliteCHEBI:1665 (ChEBI)
3-sulfolactateMetaboliteCHEBI:58738 (ChEBI)
5-Glutamyl TaurineGeneProduct5-Glutamyl Taurine (Entrez Gene)
5-Methyl-THFMetaboliteC00440 (KEGG Compound)
ADPMetaboliteC00008 (KEGG Compound)
AHCYProtein191 (Entrez Gene)
AHCYL1Protein10768 (Entrez Gene)
AHCYL2Protein23382 (Entrez Gene)
ATPMetaboliteC00002 (KEGG Compound)
BAATGeneProduct570 (Entrez Gene)
BCKDHAGeneProduct593 (Entrez Gene)
BCKDHBGeneProduct594 (Entrez Gene)
BHMTGeneProduct635 (Entrez Gene)
CBSGeneProduct875 (Entrez Gene)
CBSGeneProductP32929 (Uniprot-TrEMBL)
CDO1GeneProduct1036 (Entrez Gene)
CKBGeneProduct1152 (Entrez Gene)
CKMGeneProduct1158 (Entrez Gene)
CKMT1AGeneProduct548596 (Entrez Gene)
CKMT1BGeneProduct1159 (Entrez Gene)
CKMT2GeneProduct1160 (Entrez Gene)
CRATGeneProduct1384 (Entrez Gene)
CSADGeneProduct51380 (Entrez Gene)
CTHGeneProduct1491 (Entrez Gene)
CreatineMetaboliteHMDB00064 (HMDB)
CreatinineMetaboliteHMDB00562 (HMDB)
DBTGeneProduct1629 (Entrez Gene)
DLDGeneProduct1738 (Entrez Gene)
DNMT1GeneProduct1786 (Entrez Gene)
DNMT3AGeneProduct1788 (Entrez Gene)
DNMT3BGeneProduct1789 (Entrez Gene)
DNMT3LGeneProduct29947 (Entrez Gene)
GAD1GeneProduct2571 (Entrez Gene)
GAD2GeneProduct2572 (Entrez Gene)
GADL1GeneProduct339896 (Entrez Gene)
GCLCGeneProduct2729 (Entrez Gene)
GCLMGeneProduct2730 (Entrez Gene)
GGT1GeneProduct2678 (Entrez Gene)
GGT5GeneProduct2687 (Entrez Gene)
GGT6GeneProduct124975 (Entrez Gene)
GGT7GeneProduct2686 (Entrez Gene)
GOT1GeneProduct2805 (Entrez Gene)
GOT2GeneProduct2806 (Entrez Gene)
GSSGeneProduct2937 (Entrez Gene)
GlutathioneMetaboliteC00051 (KEGG Compound)
HypotaurineMetaboliteC000519 (KEGG Compound)
L-CystathionineMetaboliteHMDB00099 (HMDB)
L-CysteateMetaboliteCHEBI:6206 (ChEBI)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-GlutamateMetaboliteC00025 (KEGG Compound)
L-HomocysteineMetaboliteC00155 (KEGG Compound)
L-MethionineMetaboliteC00073 (KEGG Compound)
LDHAGeneProduct3939 (Entrez Gene)
LDHAL6AGeneProduct160287 (Entrez Gene)
LDHAL6BGeneProduct92483 (Entrez Gene)
LDHBGeneProduct3945 (Entrez Gene)
LDHCGeneProduct3948 (Entrez Gene)
MAT1AGeneProduct4143 (Entrez Gene)
MAT2AGeneProduct4144 (Entrez Gene)
MAT2BGeneProduct27430 (Entrez Gene)
MDH1GeneProduct4190 (Entrez Gene)
MDH2GeneProduct4191 (Entrez Gene)
MPSTGeneProduct4357 (Entrez Gene)
MTRGeneProduct4548 (Entrez Gene)
PYRUVATE METABOLISMPathway
PhosphateMetaboliteC00009 (KEGG Compound)
PhosphocreatineMetaboliteHMDB01511 (HMDB)
Propionyl-CoAMetaboliteHMDB01275 (HMDB)
PropionylcarnitineMetaboliteHMDB00824 (HMDB)
PyruvateMetaboliteC00022 (KEGG Compound)
S-Adenosylhomocysteine (SAH)MetaboliteC00021 (KEGG Compound)
S-Adenosylmethionine (SAMe)MetaboliteC00019 (KEGG Compound)
SOProteinF8VX56 (Uniprot-TrEMBL)
SPONTANOUSPathway
SulfiteMetaboliteHMDB00240 (HMDB)
TaurineMetaboliteHMDB00251 (HMDB)
TaurocholateMetaboliteCHEBI:28865 (ChEBI)
Tetrahydrofolate (THF)MetaboliteC00101 (KEGG Compound)

Annotated Interactions

No annotated interactions

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