Trans-sulfuration pathway (Homo sapiens)
From WikiPathways
Description
Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.
Quality Tags
Ontology Terms
Saving...Bibliography
- Beger RD, Sun J, Schnackenberg LK.; ''Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity''; doi: 10.1016/j.taap.2009.11.019, 2010 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2-Hydroxybutyrate | Metabolite | CHEBI:50613 (ChEBI)  | |
| 2-Ketobutyric acid | Metabolite | CHEBI:30831 (ChEBI) | |
| 3-Sulfinoalanine | Metabolite | HMDB00996 (HMDB) | |
| 3-Sulfinopyruvate | Metabolite | CHEBI:1665 (ChEBI) | |
| 3-sulfolactate | Metabolite | CHEBI:58738 (ChEBI) | |
| 5-Glutamyl Taurine | GeneProduct | ||
| 5-Methyl-THF | Metabolite | C00440 (KEGG Compound) | |
| ADP | Metabolite | C00008 (KEGG Compound) | |
| AHCY | Protein | 191 (Entrez Gene) | |
| AHCYL1 | Protein | 10768 (Entrez Gene) | |
| AHCYL2 | Protein | 23382 (Entrez Gene) | |
| ATP | Metabolite | C00002 (KEGG Compound) | |
| BAAT | GeneProduct | 570 (Entrez Gene) | |
| BCKDHA | GeneProduct | 593 (Entrez Gene) | |
| BCKDHB | GeneProduct | 594 (Entrez Gene) | |
| BHMT | GeneProduct | 635 (Entrez Gene) | |
| CBS | GeneProduct | 875 (Entrez Gene) | |
| CBS | GeneProduct | P32929 (Uniprot-TrEMBL) | |
| CDO1 | GeneProduct | 1036 (Entrez Gene) | |
| CKB | GeneProduct | 1152 (Entrez Gene) | |
| CKM | GeneProduct | 1158 (Entrez Gene) | |
| CKMT1A | GeneProduct | 548596 (Entrez Gene) | |
| CKMT1B | GeneProduct | 1159 (Entrez Gene) | |
| CKMT2 | GeneProduct | 1160 (Entrez Gene) | |
| CRAT | GeneProduct | 1384 (Entrez Gene) | |
| CSAD | GeneProduct | 51380 (Entrez Gene) | |
| CTH | GeneProduct | 1491 (Entrez Gene) | |
| Creatine | Metabolite | HMDB00064 (HMDB) | |
| Creatinine | Metabolite | HMDB00562 (HMDB) | |
| DBT | GeneProduct | 1629 (Entrez Gene) | |
| DLD | GeneProduct | 1738 (Entrez Gene) | |
| DNMT1 | GeneProduct | 1786 (Entrez Gene) | |
| DNMT3A | GeneProduct | 1788 (Entrez Gene) | |
| DNMT3B | GeneProduct | 1789 (Entrez Gene) | |
| DNMT3L | GeneProduct | 29947 (Entrez Gene) | |
| GAD1 | GeneProduct | 2571 (Entrez Gene) | |
| GAD2 | GeneProduct | 2572 (Entrez Gene) | |
| GADL1 | GeneProduct | 339896 (Entrez Gene) | |
| GCLC | GeneProduct | 2729 (Entrez Gene) | |
| GCLM | GeneProduct | 2730 (Entrez Gene) | |
| GGT1 | GeneProduct | 2678 (Entrez Gene) | |
| GGT5 | GeneProduct | 2687 (Entrez Gene) | |
| GGT6 | GeneProduct | 124975 (Entrez Gene) | |
| GGT7 | GeneProduct | 2686 (Entrez Gene) | |
| GOT1 | GeneProduct | 2805 (Entrez Gene) | |
| GOT2 | GeneProduct | 2806 (Entrez Gene) | |
| GSS | GeneProduct | 2937 (Entrez Gene) | |
| Glutathione | Metabolite | C00051 (KEGG Compound) | |
| Hypotaurine | Metabolite | C000519 (KEGG Compound) | |
| L-Cystathionine | Metabolite | HMDB00099 (HMDB) | |
| L-Cysteate | Metabolite | CHEBI:6206 (ChEBI) | |
| L-Cysteine | Metabolite | C00097 (KEGG Compound) | |
| L-Glutamate | Metabolite | C00025 (KEGG Compound) | |
| L-Homocysteine | Metabolite | C00155 (KEGG Compound) | |
| L-Methionine | Metabolite | C00073 (KEGG Compound) | |
| LDHA | GeneProduct | 3939 (Entrez Gene) | |
| LDHAL6A | GeneProduct | 160287 (Entrez Gene) | |
| LDHAL6B | GeneProduct | 92483 (Entrez Gene) | |
| LDHB | GeneProduct | 3945 (Entrez Gene) | |
| LDHC | GeneProduct | 3948 (Entrez Gene) | |
| MAT1A | GeneProduct | 4143 (Entrez Gene) | |
| MAT2A | GeneProduct | 4144 (Entrez Gene) | |
| MAT2B | GeneProduct | 27430 (Entrez Gene) | |
| MDH1 | GeneProduct | 4190 (Entrez Gene) | |
| MDH2 | GeneProduct | 4191 (Entrez Gene) | |
| MPST | GeneProduct | 4357 (Entrez Gene) | |
| MTR | GeneProduct | 4548 (Entrez Gene) | |
| PYRUVATE METABOLISM | Pathway | ||
| Phosphate | Metabolite | C00009 (KEGG Compound) | |
| Phosphocreatine | Metabolite | HMDB01511 (HMDB) | |
| Propionyl-CoA | Metabolite | HMDB01275 (HMDB) | |
| Propionylcarnitine | Metabolite | HMDB00824 (HMDB) | |
| Pyruvate | Metabolite | C00022 (KEGG Compound) | |
| S-Adenosylhomocysteine (SAH) | Metabolite | C00021 (KEGG Compound) | |
| S-Adenosylmethionine (SAMe) | Metabolite | C00019 (KEGG Compound) | |
| SO | Protein | F8VX56 (Uniprot-TrEMBL) | |
| SPONTANOUS | Pathway | ||
| Sulfite | Metabolite | HMDB00240 (HMDB) | |
| Taurine | Metabolite | HMDB00251 (HMDB) | |
| Taurocholate | Metabolite | CHEBI:28865 (ChEBI) | |
| Tetrahydrofolate (THF) | Metabolite | C00101 (KEGG Compound) |
Annotated Interactions
No annotated interactions
