Monoamine transport (Homo sapiens)

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41630163030163025, 282385, 21182, 2692315, 2472220101672, 142296812233251616151214121510722621617, 1816302619, 27991281947, 13, 1511141220Negative TransportGolgiProtein ModificationCell MembraneExpressionLEGENDTransportRegulationNegative ExpressionSmall MoleculeBindingNucleusSynthesis Negative RegulationProteinAMPHSCAMP2SYN1STX1ATSC2RBL2HEPESreserpinenoradrenalineanisomycinPVRL2TNFSLC5A7FBXO32SLC6A2ITGB3SB 203580CDC25CNOS1ACHEdopamineepinephrineDBHTDO24-Aminobutanoic acidTNFRSF11BcatecholaminesAGTSLC6A3serotoninTPH2Hemicholinium-3HRH3MAPK14TGFB1I1Phorbol esterSLC6A1IL1R1citalopramUNC13BL-tryptophanADORA2ATHPPP2CBIL1BSLC6A4


Description

Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Three major classes of MATs (SERT, DAT, NET) are responsible for the reuptake of their associated amine neurotransmitters (serotonin, dopamine, norepinephrine). MATs are located just outside the synaptic cleft (peri-synaptically), transporting monoamine transmitter overflow from the synaptic cleft back to the cytoplasm of the pre-synaptic neuron.[1] MAT regulation generally occurs through phosphorylation and posttranslational modification.[2] Due to their significance in neuronal signaling, MATs are commonly associated with drugs used to treat mental disorders as well as recreational drugs. [From: https://en.wikipedia.org/wiki/Monoamine_transporter ]

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Bibliography

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  1. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
  2. Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI; ''Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia
  3. Carneiro AM, Blakely RD; ''Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  4. Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD; ''Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  5. Hahn MK, Robertson D, Blakely RD; ''A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters.''; J Neurosci, 2003 PubMed Europe PMC Scholia
  6. Miner LH, Jedema HP, Moore FW, Blakely RD, Grace AA, Sesack SR; ''Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  7. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  8. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  9. Williams JM, Owens WA, Turner GH, Saunders C, Dipace C, Blakely RD, France CP, Gore JC, Daws LC, Avison MJ, Galli A; ''Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  10. Iwamoto H, Blakely RD, De Felice LJ; ''Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  11. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
  12. Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, Quick MW, Blakely RD; ''A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity.''; J Neurosci, 2003 PubMed Europe PMC Scholia
  13. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  14. Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  15. Jayanthi LD, Samuvel DJ, Blakely RD, Ramamoorthy S; ''Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  16. Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD; ''Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  17. Hahn MK, Blakely RD; ''Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders.''; Pharmacogenomics J, 2002 PubMed Europe PMC Scholia
  18. Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD; ''p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  19. Miner LH, Schroeter S, Blakely RD, Sesack SR; ''Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals.''; J Comp Neurol, 2003 PubMed Europe PMC Scholia
  20. Dipace C, Sung U, Binda F, Blakely RD, Galli A; ''Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes.''; Mol Pharmacol, 2007 PubMed Europe PMC Scholia
  21. Savchenko V, Sung U, Blakely RD; ''Cell surface trafficking of the antidepressant-sensitive norepinephrine transporter revealed with an ectodomain antibody.''; Mol Cell Neurosci, 2003 PubMed Europe PMC Scholia
  22. Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  23. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  24. Zhu CB, Blakely RD, Hewlett WA; ''The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters.''; Neuropsychopharmacology, 2006 PubMed Europe PMC Scholia
  25. Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, Dingledine R, Gorman JM, Grigoriadis DE, Henderson DC, B Innis RB, Killen J, Laughren TP, McDonald WM, M Murphy GM Jr, Paul SM, Rudorfer MV, Sausville E, Schatzberg AF, Scolnick EM, Suppes T; ''''; , PubMed Europe PMC Scholia
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  27. Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD; ''Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  28. Hahn MK, Blakely RD; ''The functional impact of SLC6 transporter genetic variation.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  29. Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N; ''Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75.''; Neuroscience, 2008 PubMed Europe PMC Scholia
  30. Steiner JA, Carneiro AM, Blakely RD; ''Going with the flow: trafficking-dependent and -independent regulation of serotonin transport.''; Traffic, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134168view00:36, 16 July 2024EweitzStandard node color, case; lighten organelles; economize layout
134167view00:21, 16 July 2024EweitzIncrease font size, for readability
134166view00:10, 16 July 2024EweitzRefine Golgi layout placement
134165view00:07, 16 July 2024EweitzEconomize layout
134164view00:05, 16 July 2024EweitzMitigate Golgi layout discrepancy between PathVisio and Kaavio / Pvjs
134163view00:01, 16 July 2024EweitzRefine legend, economize layout
134162view23:54, 15 July 2024EweitzUse standard organelle graphics, standardize node height
134161view21:56, 15 July 2024EweitzEconomize layout
134160view21:55, 15 July 2024EweitzStandardize case
134159view21:54, 15 July 2024EweitzEconomize layout
116775view09:48, 14 May 2021EweitzModified title
107191view14:28, 17 September 2019MaintBotChEBI identifier normalization
106651view21:13, 12 September 2019KhanspersModified description
105652view05:13, 10 August 2019KhanspersModified description
97828view06:16, 10 June 2018EgonwUndo revision 97756 by [[Special:Contributions/DeSl|DeSl]] ([[User talk:DeSl|Talk]]) Text cannot be copied from other websites.
97756view13:18, 7 June 2018DeSlModified description
94734view14:58, 5 October 2017Mkutmonfix unconnected lines
90193view20:21, 21 October 2016Khanspersfixed unconnected in legend
88905view08:41, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79969view18:59, 28 April 2015Zariannotated anisomycin and catecholamines metabolites
68928view17:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
67491view11:08, 26 June 2013DdiglesOntology Term : 'monoamine transport pathway' added !
41075view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
40001view19:05, 23 January 2011AlexanderPicomore descriptive title
34584view22:25, 21 December 2009KhanspersModified categories
34456view18:24, 10 December 2009MaintBotAutomatic update of empty xrefs
33664view20:54, 2 December 2009Dex duncanadd registered user
33426view14:54, 30 November 2009MaintBotRemoved group label
33355view19:10, 24 November 2009Bzhangname change
30181view21:59, 7 July 2009BzhangNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-Aminobutanoic acidMetabolite56-12-2 (CAS)
ACHEGeneProduct43 (Entrez Gene) acetylcholinesterase (Yt blood group)
ADORA2AGeneProduct135 (Entrez Gene) adenosine A2a receptor
AGTGeneProduct183 (Entrez Gene) angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMPHGeneProduct273 (Entrez Gene) amphiphysin
CDC25CGeneProduct995 (Entrez Gene) cell division cycle 25 homolog C (S. pombe)
DBHGeneProduct1621 (Entrez Gene) dopamine beta-hydroxylase (dopamine beta-monooxygenase)
FBXO32GeneProduct114907 (Entrez Gene) F-box protein 32
HEPESMetabolite7365-45-9 (CAS)
HRH3GeneProduct11255 (Entrez Gene) histamine receptor H3
Hemicholinium-3Metabolite312-45-8 (CAS)
IL1BGeneProduct3553 (Entrez Gene) interleukin 1 beta
IL1R1GeneProduct3554 (Entrez Gene) interleukin 1 receptor, type I
ITGB3GeneProduct3690 (Entrez Gene) integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
L-tryptophanMetabolite73-22-3 (CAS)
MAPK14GeneProduct1432 (Entrez Gene) mitogen activated protein kinase 14
NOS1GeneProduct4842 (Entrez Gene) nitric oxide synthase 1 (neuronal)
PPP2CBGeneProduct5516 (Entrez Gene) protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
PVRL2GeneProduct5819 (Entrez Gene) poliovirus receptor-related 2 (herpesvirus entry mediator B)
Phorbol esterMetabolite16561-29-8 (CAS)
RBL2GeneProduct5934 (Entrez Gene) retinoblastoma-like 2 (p130)
SB 203580Metabolite152121-47-6 (CAS)
SCAMP2GeneProduct10066 (Entrez Gene) secretory carrier membrane protein 2
SLC5A7GeneProduct60482 (Entrez Gene) solute carrier family 5 (choline transporter), member 7
SLC6A1GeneProduct6529 (Entrez Gene) solute carrier family 6 (neurotransmitter transporter, GABA), member 1
SLC6A2GeneProduct6530 (Entrez Gene) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
SLC6A3GeneProduct6531 (Entrez Gene) solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
SLC6A4GeneProduct6532 (Entrez Gene) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
STX1AGeneProduct6804 (Entrez Gene) syntaxin 1A (brain)
SYN1GeneProduct6853 (Entrez Gene) synapsin I
TDO2GeneProduct6999 (Entrez Gene) tryptophan 2,3-dioxygenase
TGFB1I1GeneProduct7041 (Entrez Gene) transforming growth factor beta 1 induced transcript 1
THGeneProduct7054 (Entrez Gene) tyrosine hydroxylase
TNFGeneProduct7124 (Entrez Gene) tumor necrosis factor
TNFRSF11BGeneProduct4982 (Entrez Gene) tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
TPH2GeneProduct121278 (Entrez Gene) tryptophan hydroxylase 2
TSC2GeneProduct7249 (Entrez Gene) tuberous sclerosis 2
UNC13BGeneProduct10497 (Entrez Gene) unc-13 homolog B (C. elegans)
anisomycinMetabolite338412 (ChEBI)
catecholaminesMetabolite33567 (ChEBI)
citalopramMetabolite59729-33-8 (CAS)
dopamineMetabolite51-61-6 (CAS)
epinephrineMetabolite51-43-4 (CAS)
noradrenalineMetabolite51-41-2 (CAS)
reserpineMetabolite50-55-5 (CAS)
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions

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