Apoptosis modulation by HSP70 (Homo sapiens)

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1-8MitochondrionCELL SURVIVALApoptosomeDegradation of proteinsDegradation ofIk alpha(activation of NFkB)ProteasomeSTRESSCASP7FADDApoptosisCASP9FAS-LigandTNFRSF1AFADDHSPA1AHSPA1ACYCSHSPA1APDCD8MAPK10MAP3K1CASP3RIPK1NF-kB PathwayFASAPAF1CASP2BIDNFKB1CASP8CYCSCASP6CASP8TNF-alpha


Description

Cellular stress can trigger a process of self-destruction known as apoptosis. Cells can also respond to stress by adaptive changes that increase their ability to tolerate normally lethal conditions. The major heat shock protein, Hsp70, is an effective inhibitor of apoptosis. Hsp70 rescues cells from apoptosis later in the death signaling pathway than any known anti-apoptotic protein. Down regulation of Hsp70 could be interesting in treatment for cancer.

Comments

GenMAPP remarks 
Adapted from rat by GenMAPP

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY; ''Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.''; FEBS Lett, 1998 PubMed Europe PMC Scholia
  2. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG; ''The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  3. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G; ''Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.''; FASEB J, 1999 PubMed Europe PMC Scholia
  4. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M; ''Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.''; EMBO J, 1998 PubMed Europe PMC Scholia
  5. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G; ''HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
  6. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES; ''Negative regulation of the Apaf-1 apoptosome by Hsp70.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  7. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B; ''The chaperone function of hsp70 is required for protection against stress-induced apoptosis.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C; ''Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.''; Oncogene, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126334view06:05, 22 April 2023EgonwLicense is CCZero
121706view04:40, 26 February 2022EweitzUse gene symbol
119819view10:16, 28 August 2021EgonwMade two pathways clickable
117650view11:44, 22 May 2021EweitzModified title
106301view17:43, 20 August 2019KhanspersModified description
105533view06:03, 9 August 2019KhanspersModified description
98535view20:48, 14 September 2018KhanspersModified description
98532view20:39, 14 September 2018Khanspersremoved GenMAPP comments
98531view20:38, 14 September 2018KhanspersModified description
97821view15:15, 9 June 2018EgonwReverted to version '10:00, 26 June 2013' by Egonw
97767view13:31, 7 June 2018LorasimonsModified description
97763view13:28, 7 June 2018LorasimonsModified description
67054view10:00, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
65167view18:35, 5 June 2013MaintBotfixed wp db ref
63164view20:24, 8 May 2013MaintBotUpdating GPML version
62245view21:42, 26 April 2013AlexanderPicoOverhaul of component representations
62244view21:29, 26 April 2013MaintBotUpdated label font
41236view23:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
38948view23:16, 24 September 2010KhanspersAdded apoptosis link
38947view23:14, 24 September 2010Khanspers
38802view07:23, 24 September 2010Jildaumitochondrion
34959view22:23, 8 February 2010KhanspersMoved lit refs from Comments to Bibliography
32416view17:07, 15 August 2009MaintBotFixed text labels
32073view13:37, 14 August 2009MaintBotFixed group labels
29910view14:04, 9 June 2009PaoloRomanoPeriodical save, work in progress
21486view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:HSP70 and Apoptosis]] moved to [[Pathway:WP384]]: Moved to stable identifier
15411view23:12, 27 May 2008Khanspersconnectors fix
14704view21:17, 23 May 2008KhanspersAdded connectors
12967view10:57, 17 May 2008MaintBotSticky edges patch by Sjoerd
8140view13:46, 7 January 2008MaintBot[[Pathway:Human:HSP70 and Apoptosis]] moved to [[Pathway:Homo sapiens:HSP70 and Apoptosis]]: Renaming species
7690view16:09, 18 December 2007MaintBotfixed category names
7232view12:41, 4 November 2007MaintBotAdded categories to GPML
6330view22:17, 22 May 2007I.Reyesgpml file for [[Human:HSP70_and_Apoptosis]]

External references

DataNodes

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NameTypeDatabase referenceComment
APAF1GeneProduct317 (Entrez Gene)
ApoptosisPathwayWP254 (WikiPathways)
BIDGeneProduct637 (Entrez Gene)
CASP2GeneProduct835 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP6GeneProduct839 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP8GeneProduct841 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CYCSGeneProduct54205 (Entrez Gene)
FADDGeneProduct8772 (Entrez Gene)
FAS-LigandGeneProductENSG00000117560 (Ensembl)
FASGeneProduct355 (Entrez Gene)
HSPA1AGeneProduct3303 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
NF-kB PathwayPathway
NFKB1GeneProduct4790 (Entrez Gene)
PDCD8GeneProduct9131 (Entrez Gene) Apoptosis Inducing Factor
RIPK1GeneProduct8737 (Entrez Gene)
TNF-alphaGeneProductENSG00000204490 (Ensembl)
TNFRSF1AGeneProduct7132 (Entrez Gene)

Annotated Interactions

No annotated interactions
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