Lamin A processing pathway (Homo sapiens)
From WikiPathways
Description
Lamin-A processing pathway. Showing modifications of pre-lamin A to produce mature lamin A.
Quality Tags
Ontology Terms
Pathway Ontology : classic metabolic pathway
Bibliography
- Cox LS, Faragher RG; ''From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.''; Cell Mol Life Sci, 2007 PubMed Europe PMC Scholia
- Broers JL, Ramaekers FC, Bonne G, Yaou RB, Hutchison CJ; ''Nuclear lamins: laminopathies and their role in premature ageing.''; Physiol Rev, 2006 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
15 amino acids | |||
AAX | |||
CAAX prenyl protease 1 homolog | Protein | O75844 (Uniprot-TrEMBL) ![]() | |
C | Metabolite | CHEBI:27594 (ChEBI) ![]() | |
Farnesyl transferase | Protein | ||
LMNA | GeneProduct | ENSG00000160789 (Ensembl) ![]() | |
Mature lamin A | Protein | 72 kDa | |
Pre-lamin A | GeneProduct | P02545 (Uniprot-TrEMBL) ![]() | |
Protein-S-isoprenylcysteine O-methyltransferase | Protein | O60725 (Uniprot-TrEMBL) ![]() | |
ZMPSTE24 | GeneProduct | ENSG00000084073 (Ensembl) ![]() |
Annotated Interactions
No annotated interactions