Lamin A processing pathway (Homo sapiens)

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CCaaX group1CaaX groupCH3Farnesyl group15 amino acidsZMPSTE24Farnesyl transferaseLMNAaaXCAAX prenyl protease 1 homologMature lamin AProtein-S-isoprenylcysteine O-methyltransferasePre-lamin ACPre-lamin APre-lamin ACAAX prenyl protease 1 homologZMPSTE24CPre-lamin A


Description

Lamin-A processing pathway. Showing modifications of pre-lamin A to produce mature lamin A.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Cox LS, Faragher RG; ''From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.''; Cell Mol Life Sci, 2007 PubMed Europe PMC Scholia
  2. Broers JL, Ramaekers FC, Bonne G, Yaou RB, Hutchison CJ; ''Nuclear lamins: laminopathies and their role in premature ageing.''; Physiol Rev, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128824view23:55, 22 February 2024EweitzModified title
126536view09:46, 29 May 2023EgonwTyped a datanode and added a ChEBI identifier
120397view08:59, 30 November 2021Fehrhartboxed pathway node
110694view13:52, 28 May 2020LaurentAdded missing DataNode type
108074view11:42, 28 November 2019FehrhartModified description
108073view11:41, 28 November 2019FehrhartOntology Term : 'progeria' added !
108072view11:41, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
108071view11:41, 28 November 2019FehrhartOntology Term : 'Disease' added !
98006view12:48, 2 July 2018DeSlConnected line
98005view12:48, 2 July 2018DeSlAdded PW link to progeria syndrome PW.
97976view13:48, 28 June 2018FehrhartOntology Term : 'signaling pathway' added !
97954view12:36, 26 June 2018LorasimonsC annotated as cysteine
97951view11:35, 26 June 2018LorasimonsModified description
97950view11:27, 26 June 2018LorasimonsAdded literature
97949view11:25, 26 June 2018LorasimonsModified description
97948view11:25, 26 June 2018LorasimonsModified description
97947view11:24, 26 June 2018LorasimonsModified description
97946view11:23, 26 June 2018LorasimonsChanged layout
97911view15:39, 23 June 2018EgonwAnd now really to the protein.
97910view15:14, 23 June 2018EgonwHave the arrow go from protein to protein here too.
97749view13:08, 7 June 2018DeSlAdded weight for mature lamin A (no ID)
97733view12:57, 7 June 2018DeSlChanged C-labels to Metabolites, added ChEBI ID.
97635view13:17, 31 May 2018LorasimonsStraightening lines
97634view13:10, 31 May 2018LorasimonsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15 amino acids
CAAX prenyl protease 1 homologProteinO75844 (Uniprot-TrEMBL)
CMetaboliteCHEBI:27594 (ChEBI)
Farnesyl transferaseProtein
LMNAGeneProductENSG00000160789 (Ensembl)
Mature lamin AProtein72 kDa
Pre-lamin AGeneProductP02545 (Uniprot-TrEMBL)
Protein-S-isoprenylcysteine O-methyltransferaseProteinO60725 (Uniprot-TrEMBL)
ZMPSTE24GeneProductENSG00000084073 (Ensembl)
aaX

Annotated Interactions

No annotated interactions

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