Rett syndrome (Homo sapiens)

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19825272711315142811641024221423219171852616214201273NCoR complex14SMARCA4TCF4NCOR2STXBP1GRIN2AXAB2SATB2GRIN2BJARID1BCRKSCN8AACTL6BHIVEP2FOXG1EIF2B2KCNJ10SHANK3SCN2ASYNGAP1TAF1BHDAC5HDAC1KCNQ2CHD4MECP2GABRDSMC1ARHOBTB2SYNE2HAP1SCN1ACDKL5NCOR1SMARCA1GPS2TRRAPHTTTBL1XSRRM3MEF2CBRAFSMARCA2CECR2IMPDH2GNAO1GABRA3TCF4GABBR2HDAC8TBL1XR1


Description

Protein-protein interactions between genes that are associated with Rett syndrome according to the paper "Ehrhart, F., Sangani, N. B., & Curfs, L. M. (2018). Current developments in the genetics of Rett and Rett-like syndrome. Current opinion in psychiatry, 31(2), 103-108."

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134292view05:54, 20 July 2024EgonwRemoved template comments
128465view21:53, 4 February 2024EweitzModified title
123518view20:14, 31 July 2022EgonwMoved KEGG pathway identifiers to the comment as they are not reaction identifiers
119230view18:54, 22 June 2021Finterlyadded DOI information
104287view12:47, 15 May 2019FehrhartOntology Term : 'neuron' added !
101964view11:00, 21 November 2018DeSlAdded ID for last wrong interaction drawing as a comment (for easy fixing later on).
101963view10:53, 21 November 2018DeSlFixed one before last wrong interaction link (keeping one for new Jenkins Test).
101962view10:51, 21 November 2018DeSlChanged more names of PWs on interactions to corresponding ID; added name to comments.
101958view10:42, 21 November 2018DeSlAdded name of "Viral carcinogenesis" to interaction as comment.
101957view10:30, 21 November 2018DeSlChanged Viral carcinogenesis pathway to ID from KEGG.
98050view05:39, 13 July 2018Fehrhartfixed unconnected line
98028view10:03, 4 July 2018FehrhartModified description
98026view09:33, 4 July 2018DeSlChanged Ref. layout
98024view09:25, 4 July 2018DeSlChanged Ref. layout
98023view09:23, 4 July 2018DeSlChanged Ref. layout
98022view09:22, 4 July 2018FehrhartModified description
98021view09:22, 4 July 2018FehrhartModified description
98020view09:21, 4 July 2018FehrhartModified description
98019view09:06, 4 July 2018DeSlChanges layout (again).
98018view09:05, 4 July 2018DeSlMore layout changes, every single line should be visible now in terms of connectivity
98017view09:02, 4 July 2018DeSlChanged layout some more
98016view09:00, 4 July 2018DeSlChanged layout, how lines are connected etc.
98015view08:52, 4 July 2018DeSlFound Gene ID in left bottom corner, which screwed up visualisation
98009view08:13, 3 July 2018FehrhartModified description
98008view08:11, 3 July 2018Fehrhartaesthetics
97973view09:16, 28 June 2018Fehrhartsome aesthetic details
97972view09:12, 28 June 2018FehrhartModified title
97971view07:25, 28 June 2018FehrhartOntology Term : 'disease pathway' added !
97970view07:24, 28 June 2018FehrhartOntology Term : 'Rett syndrome' added !
97969view07:24, 28 June 2018FehrhartModified title
97892view11:05, 20 June 2018MaxvansonErased some unnecessary genes that were not present in the pathway
97891view10:12, 20 June 2018MaxvansonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTL6BGeneProductENSG00000077080 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CDKL5 GeneProductENSG00000008086 (Ensembl)
CECR2GeneProductENSG00000099954 (Ensembl)
CHD4GeneProductENSG00000111642 (Ensembl)
CRKGeneProductENSG00000167193 (Ensembl)
EIF2B2GeneProductENSG00000119718 (Ensembl)
ENSG00000119718GeneProductEIF2B2
FOXG1 GeneProductENSG00000176165 (Ensembl)
GABBR2GeneProductENSG00000136928 (Ensembl)
GABRA3GeneProductENSG00000011677 (Ensembl)
GABRDGeneProductENSG00000187730 (Ensembl)
GNAO1GeneProductENSG00000087258 (Ensembl)
GPS2GeneProductENSG00000132522 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
HAP1GeneProductENSG00000173805 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC5GeneProductENSG00000108840 (Ensembl)
HDAC8GeneProductENSG00000147099 (Ensembl)
HIVEP2GeneProductENSG00000010818 (Ensembl) Type your comment here
HTTGeneProductENSG00000197386 (Ensembl)
IMPDH2GeneProductENSG00000178035 (Ensembl)
JARID1B GeneProductENSG00000117139 (Ensembl)
KCNJ10GeneProductENSG00000177807 (Ensembl)
KCNQ2GeneProductENSG00000281151 (Ensembl)
MECP2 GeneProductENSG00000169057 (Ensembl)
MEF2CGeneProductENSG00000081189 (Ensembl)
NCOR1GeneProductENSG00000141027 (Ensembl)
NCOR2GeneProductENSG00000196498 (Ensembl)
RHOBTB2GeneProductENSG00000008853 (Ensembl)
SATB2GeneProductENSG00000119042 (Ensembl)
SCN1AGeneProductENSG00000144285 (Ensembl)
SCN2AGeneProductENSG00000136531 (Ensembl)
SCN8AGeneProductENSG00000196876 (Ensembl)
SHANK3GeneProductENSG00000251322 (Ensembl)
SMARCA1GeneProductENSG00000102038 (Ensembl)
SMARCA2 GeneProductENSG00000080503 (Ensembl)
SMARCA4 GeneProductENSG00000127616 (Ensembl)
SMC1AGeneProductENSG00000072501 (Ensembl)
SRRM3GeneProductENSG00000177679 (Ensembl)
STXBP1GeneProductENSG00000136854 (Ensembl)
SYNE2GeneProductENSG00000054654 (Ensembl)
SYNGAP1GeneProductENSG00000197283 (Ensembl)
TAF1BGeneProductENSG00000115750 (Ensembl)
TBL1XGeneProductENSG00000101849 (Ensembl)
TBL1XR1GeneProductENSG00000177565 (Ensembl)
TCF4GeneProductENSG00000196628 (Ensembl)
TRRAPGeneProductENSG00000196367 (Ensembl)
XAB2GeneProductENSG00000076924 (Ensembl)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
CRKBRAFmim-gapNeurotrophin signaling pathway (KEGG Pathway)
GABRDGABRA3mim-bindingNicotine addiction (KEGG Pathway)
GNAO1GABBR2mim-stimulationGABAergic Synapse (KEGG Pathway)
GNAO1mim-inhibitionDopaminergic Synapse (KEGG Pathway)
GRIN2BGRIN2Amim-bindingAlcoholism (KEGG Pathway)
HAP1GABRA3mim-bindingGABAergic synapse (KEGG Pathway)
HAP1GABRDmim-bindingGABAergic synapse (KEGG Pathway)
HDAC5CHD4mim-stimulationViral Carcinogenesis (KEGG Pathway)
HDAC8HDAC5mim-bindingAlcoholism (KEGG Pathway)
HTTGRIN2Bmim-cleavageHuntington's Disease (KEGG Pathway) Type your comment here
KCNJ10GABBR2mim-stimulationGABA B receptor G-protein beta-gamma and Kir3 channel complex (Reactome)
SYNE2SMC1Amim-gapMeiotic synapsis pathway (KEGG Pathway)
TAF1BCHD4mim-stimulationSIRT1 negatively regulates rRNA expression (Reactome)
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