Effect of progerin on genes involved in progeria (Homo sapiens)

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Nuclear abnormalitiesHeterochromatin silencingMi-2/NuRD complexTranscriptionHP1Accumulation DNA damageTranscriptionEuchromatin silencingDysfunctional adipose tissueMethyl groupMethylationProgerinRBBP4CBX1MBD2SERBP1E2F1HDAC2KDM1AHistone H3.2SKIPMBD3MTA1CBX3CBX5MTA3Histone H3.3p53 pathwayMTA2Notch signalingCHD3Histone H3.1LEF1HDAC1CHD4RBBP7Wnt pathwayHistone H3.2Histone H3.3Histone H3.1SUV39H1CBX1CBX3CBX5SUV39H1RB1TP53Bone abnormalitiesEpigenetic changesApoptosis/senescence


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Daemen S, Kutmon M, Evelo CT; ''A pathway approach to investigate the function and regulation of SREBPs.''; Genes Nutr, 2013 PubMed Europe PMC Scholia
  2. Zhang Y, Reinberg D; ''Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.''; Genes Dev, 2001 PubMed Europe PMC Scholia
  3. Hernandez L, Roux KJ, Wong ES, Mounkes LC, Mutalif R, Navasankari R, Rai B, Cool S, Jeong JW, Wang H, Lee HS, Kozlov S, Grunert M, Keeble T, Jones CM, Meta MD, Young SG, Daar IO, Burke B, Perantoni AO, Stewart CL; ''Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.''; Dev Cell, 2010 PubMed Europe PMC Scholia
  4. Vidak S, Foisner R; ''Molecular insights into the premature aging disease progeria.''; Histochem Cell Biol, 2016 PubMed Europe PMC Scholia
  5. Millard CJ, Varma N, Saleh A, Morris K, Watson PJ, Bottrill AR, Fairall L, Smith CJ, Schwabe JW; ''The structure of the core NuRD repression complex provides insights into its interaction with chromatin.''; Elife, 2016 PubMed Europe PMC Scholia
  6. Gonzalo S, Kreienkamp R, Askjaer P; ''Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.''; Ageing Res Rev, 2017 PubMed Europe PMC Scholia
  7. Prokocimer M, Barkan R, Gruenbaum Y; ''Hutchinson-Gilford progeria syndrome through the lens of transcription.''; Aging Cell, 2013 PubMed Europe PMC Scholia
  8. Cox LS, Faragher RG; ''From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.''; Cell Mol Life Sci, 2007 PubMed Europe PMC Scholia
  9. Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS; ''Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128823view23:53, 22 February 2024EweitzModified title
128822view23:52, 22 February 2024EweitzModified description
123412view11:13, 25 July 2022EgonwMade three pathways clickable
116686view14:17, 9 May 2021EweitzModified title
108245view10:02, 2 December 2019FehrhartAdded protein ID for progeria - isoform 6 of LMNA
108063view13:20, 27 November 2019FehrhartOntology Term : 'disease pathway' added !
98049view05:35, 13 July 2018FehrhartAdded ID for p53 pathway
98027view09:40, 4 July 2018Lorasimonslayout
98025view09:31, 4 July 2018Lorasimonschange gene- SREBF1 - add references
98004view12:44, 2 July 2018DeSlChanged legend arrow to graphical line.
98003view12:43, 2 July 2018DeSlCOnnected unconnected line
97992view12:09, 29 June 2018LorasimonsOntology Term : 'progeria' added !
97991view12:08, 29 June 2018LorasimonsModified description
97990view11:47, 29 June 2018LorasimonsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CBX1GeneProductENSG00000108468 (Ensembl)
CBX3GeneProductENSG00000122565 (Ensembl)
CBX5GeneProductENSG00000094916 (Ensembl)
CHD3GeneProductENSG00000170004 (Ensembl)
CHD4GeneProductENSG00000111642 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
Histone H3.1ProteinP68431 (Uniprot-TrEMBL)
Histone H3.2ProteinQ71DI3 (Uniprot-TrEMBL)
Histone H3.3ProteinP84243 (Uniprot-TrEMBL)
KDM1AGeneProductENSG00000004487 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MBD2GeneProductENSG00000134046 (Ensembl)
MBD3GeneProductENSG00000071655 (Ensembl)
MTA1GeneProductENSG00000182979 (Ensembl)
MTA2GeneProductENSG00000149480 (Ensembl)
MTA3GeneProductENSG00000057935 (Ensembl)
Notch signalingPathwayWP268 (WikiPathways)
ProgerinProtein
RB1GeneProductENSG00000139687 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
RBBP7GeneProductENSG00000102054 (Ensembl)
SERBP1GeneProductENSG00000142864 (Ensembl)
SKIPGeneProductENSG00000132376 (Ensembl)
SUV39H1GeneProductENSG00000101945 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
Wnt pathwayPathwayWP363 (WikiPathways)
p53 pathwayPathway

Annotated Interactions

No annotated interactions

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