One-carbon metabolism and related pathways (Mus musculus)

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H2O2Oxidative stress enzymesH2OBile acid biosynthesisSod2DmgdhCsadEtnk2GlycineBetaineSarcosineL-Cysteine5-oxoprolineDnmt3aPcyt2GsrGlycineCept15-Methyltetrahydrofolic acidSod1Shmt1Gpx3Chpt1GlutamateCDP-cholineCDP-Ethanolaminegamma-GlutamylcysteineGlutathione (GSH)ChkaGpx1Bhmt2TymsSod3HomocysteineBaatEthanolamineGpx6PhosphatidylcholinesO-Phosphoethanolamine3-SulfinoalanineGnmtHypotaurineTaurineChdhBhmtAhcyl1Gad2Tetrahydrofolic acidDimethylglycineGpx4PemtMthfrChkbGclcNADPGpx7PhosphocholineTaurochenodesoxycholic acidL-SerineCholineMtrTotal PhospholipidsCbsGpx510-formyldihydrofolateMat1aDnm1L-MethionineDhfrPcyt1bL-CystathionineFolic acidL-Serine5,10-Methenyltetrahydrofolic acidS-AdenosylmethioninePhosphatidylethanolamineCthSardhTaurocholic acidGpx2Cdo1Gad1Pld1Etnk1GclmMat2aGssShmt2S-AdenosylhomocysteineNADPHGlutathione disulfide (GSSG)Pcyt1a2-oxobutanoate(S)-2-Aminobutanoategamma-L-Glutamyl-L-2-aminobutyrateOphthalmateBcat1Agxt2GclcGssBcat2Gclm


Description

This pathway shows the carbon metabolism over grey and related pathways around it. Source [1]

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
142121view06:57, 4 December 2025KhanspersModified description
137454view13:19, 2 March 2025EgonwModified description
116575view11:06, 8 May 2021EweitzModified title
107198view14:28, 17 September 2019MaintBotChEBI identifier normalization
106860view13:34, 17 September 2019MaintBotHMDB identifier normalization
98296view10:23, 17 August 2018DeSlConnected last enzyme nodes properly.
98284view12:41, 16 August 2018DeSlChecked for unconnected lines (didn't find any, will remove the Quality tag. Connected all enzymes with MIM-catalysis iso line.
98239view13:53, 14 August 2018EgonwReplace two PubChem SIDs with a PubChem CIDs.
96354view17:06, 9 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
96326view09:28, 8 March 2018Mkutmonupdate NCBI Protein identifiers to Ensembl identifiers
96325view09:20, 8 March 2018Mkutmonremove old WP category
96233view13:29, 1 March 2018DeSlRemoved licence number and last modified part.
96232view13:28, 1 March 2018DeSlAdded small side branch to opthalmate conversion.
94313view12:07, 1 September 2017Marvin M2Made minor change with connection
94311view12:02, 1 September 2017Marvin M2Connected unconnected line, changed line into graphical (no connection)
94207view21:15, 25 August 2017DeSlAdded ID for phosphocholine
78414view10:25, 7 January 2015MaintBotadded missing graphIds
71311view17:14, 17 October 2013MaintBotAutomated update of data sources
69068view18:08, 8 July 2013MaintBotUpdated to 2013 gpml schema
48487view12:08, 29 May 2012EveloImproved methionine backpage
48224view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45171view08:49, 7 October 2011ThomasOntology Term : 'folate mediated one-carbon metabolic pathway' added !
43787view21:31, 27 July 2011Samuel SklarModified description
41250view00:20, 2 March 2011MaintBotRemoved redundant pathway information and comments
39628view23:06, 4 January 2011KhanspersModified categories
39587view08:22, 28 December 2010MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-2-AminobutanoateMetaboliteCHEBI:35619 (ChEBI)
10-formyldihydrofolateMetaboliteHMDB06485 (HMDB)
2-oxobutanoateMetabolite16763 (ChEBI)
3-SulfinoalanineMetaboliteC00606 (KEGG Compound)
5,10-Methenyltetrahydrofolic acidMetaboliteC00445 (KEGG Compound)
5-Methyltetrahydrofolic acidMetaboliteC00440 (KEGG Compound)
5-oxoprolineMetaboliteC01879 (KEGG Compound)
Agxt2GeneProductENSMUSG00000089678 (Ensembl)
Ahcyl1GeneProduct229709 (Entrez Gene)
BaatGeneProduct12012 (Entrez Gene)
Bcat1GeneProductENSMUSG00000030268 (Ensembl)
Bcat2GeneProductENSMUSG00000030826 (Ensembl)
BetaineMetaboliteC00719 (KEGG Compound)
BhmtGeneProduct12116 (Entrez Gene)
Bhmt2GeneProduct64918 (Entrez Gene)
CDP-EthanolamineMetaboliteC00570 (KEGG Compound)
CDP-cholineMetaboliteC00307 (KEGG Compound)
CbsGeneProduct12411 (Entrez Gene)
Cdo1GeneProduct12583 (Entrez Gene)
Cept1GeneProduct99712 (Entrez Gene)
ChdhGeneProduct218865 (Entrez Gene)
ChkaGeneProduct12660 (Entrez Gene)
ChkbGeneProduct12651 (Entrez Gene)
CholineMetaboliteC00114 (KEGG Compound)
Chpt1GeneProduct212862 (Entrez Gene)
CsadGeneProduct246277 (Entrez Gene)
CthGeneProduct107869 (Entrez Gene)
DhfrGeneProduct13361 (Entrez Gene)
DimethylglycineMetaboliteC01026 (KEGG Compound)
DmgdhGeneProduct74129 (Entrez Gene)
Dnm1GeneProduct13429 (Entrez Gene)
Dnmt3aGeneProduct13435 (Entrez Gene)
EthanolamineMetaboliteC00189 (KEGG Compound)
Etnk1GeneProduct75320 (Entrez Gene)
Etnk2GeneProduct214253 (Entrez Gene)
Folic acidMetaboliteC00504 (KEGG Compound)
Gad1GeneProduct14415 (Entrez Gene)
Gad2GeneProduct14417 (Entrez Gene)
GclcGeneProduct14629 (Entrez Gene)
GclcGeneProductENSMUSG00000032350 (Ensembl)
GclmGeneProduct14630 (Entrez Gene)
GclmGeneProductENSMUSG00000028124 (Ensembl)
GlutamateMetaboliteC00217 (KEGG Compound)
Glutathione (GSH)MetaboliteC00051 (KEGG Compound)
Glutathione disulfide (GSSG)MetaboliteC00127 (KEGG Compound)
GlycineMetaboliteC00037 (KEGG Compound)
GnmtGeneProduct14711 (Entrez Gene)
Gpx1GeneProduct14775 (Entrez Gene)
Gpx2GeneProduct14776 (Entrez Gene)
Gpx3GeneProduct14778 (Entrez Gene)
Gpx4GeneProduct625249 (Entrez Gene)
Gpx5GeneProduct14780 (Entrez Gene)
Gpx6GeneProduct75512 (Entrez Gene)
Gpx7GeneProduct67305 (Entrez Gene)
GsrGeneProduct14782 (Entrez Gene)
GssGeneProduct14854 (Entrez Gene)
GssGeneProductENSMUSG00000027610 (Ensembl)
HomocysteineMetaboliteC05330 (KEGG Compound)
HypotaurineMetaboliteC00519 (KEGG Compound)
L-CystathionineMetaboliteC02291 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-MethionineMetaboliteHMDB00696 (HMDB)
L-SerineMetaboliteC00065 (KEGG Compound)
Mat1aGeneProduct11720 (Entrez Gene)
Mat2aGeneProduct232087 (Entrez Gene)
MthfrGeneProduct17769 (Entrez Gene)
MtrGeneProduct238505 (Entrez Gene)
NADPMetaboliteC00006 (KEGG Compound)
NADPHMetaboliteC00005 (KEGG Compound)
O-PhosphoethanolamineMetaboliteC00346 (KEGG Compound)
OphthalmateMetabolite7018721 (PubChem-compound)
Pcyt1aGeneProduct13026 (Entrez Gene)
Pcyt1bGeneProduct236899 (Entrez Gene)
Pcyt2GeneProduct68671 (Entrez Gene)
PemtGeneProduct18618 (Entrez Gene)
PhosphatidylcholinesMetabolite8002-43-5 (CAS)
PhosphatidylethanolamineMetaboliteC00350 (KEGG Compound)
PhosphocholineMetaboliteCHEBI:18132 (ChEBI)
Pld1GeneProduct18805 (Entrez Gene)
S-AdenosylhomocysteineMetaboliteC00021 (KEGG Compound)
S-AdenosylmethionineMetaboliteC00019 (KEGG Compound)
SarcosineMetaboliteC00213 (KEGG Compound)
SardhGeneProduct192166 (Entrez Gene)
Shmt1GeneProduct20425 (Entrez Gene)
Shmt2GeneProduct108037 (Entrez Gene)
Sod1GeneProduct20655 (Entrez Gene)
Sod2GeneProduct20656 (Entrez Gene)
Sod3GeneProduct20657 (Entrez Gene)
TaurineMetaboliteC00245 (KEGG Compound)
Taurochenodesoxycholic acidMetaboliteC05465 (KEGG Compound)
Taurocholic acidMetaboliteC05122 (KEGG Compound)
Tetrahydrofolic acidMetaboliteC00101 (KEGG Compound)
Total PhospholipidsMetabolite16247 (ChEBI)
TymsGeneProduct22171 (Entrez Gene)
gamma-GlutamylcysteineMetaboliteC00669 (KEGG Compound)
gamma-L-Glutamyl-L-2-aminobutyrateMetabolite7014903 (PubChem-compound)

Annotated Interactions

No annotated interactions

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