Ebola virus infection in host (Homo sapiens)

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Revision as of 19:09, 20 September 2018 by Elisson nl (Talk | contribs)
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323735346121281232ITGA2Filamin ACLEC10AASGR1ADAM17ICAM2ICAM3RHOBCD209CLEC4MHAVCR1MHC1GAS6TYRO3ITGA3ITGA4ITGA5ITGA1ITGA6ITGB1ITGB3BST2RAB7ACell MembraneRAB5ANPC1NPC2CTSBCTSLLysosomeNucleusAXLMERTKIKBKEIRF7KPNA1CLEC4GVP35VP24IQGAP1VP40TBK1EBOLAC1QBPTLR4TIMD4VIRUS'RNATPCN2TSG101STAT1NEDD4SOCS3PIK3RCDC42Trans-InfectionMHC2Macropinocytosis17IRF326Interferon ResponseExit of Secreted GPAssembly and BuddingCLATHRINITGAVsGPCytokine Signal351517203CLEC6AMBL2GP1,244444021523CAVEOLINFOLR1RHOC23973636ssGP33Transcription, Translation and ReplicationVP30Cell AdhesionImmune Surveillance LNPLopes, E. N. 2017Endosome44Fusion toCleave EnvelopeFusion to Ebola's GPChanges the pH3734343025133737GP81410RAC1519EGFR19Exit byAKT1MFGE81818CD300A1818PRKRADDX589HAVCR29IL416DAB2IPTFAP2ARAB9A27EIF2AK2EIF2S12222VPS33AVPS18VPS39VPS41VPS11VPS16NFKBVPS4A36dsRNAEPS153838ERK38RASA2RHOAGELSOLINACTIN28Actin CytoskeletonEP300CREBBP353535CDC44F-ACTINFILAMINPAK11111TIAM123VAV2IGF1R28CLTC24CLTACLTBCLTCL1CAV1CAV2CAV3PIK3R1PIK3CAPIK3CBPIK3CDPIK3R3PIK3R2IsoformsPP1LC8TOP121FLNAFLNBFLNCGSNSCINMAPK1MAPK3NFKB1NFKB2RELRELAACTN1ACTN4ACTBACTG1HLA-AHLA-BHLA-CHLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-EHLA-FHLA-GHLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB3HLA-DRB4HLA-DRB566342234313173343321313131966137182019136421172127262117234137131361366632626613131362206661322422243222262226666261361010202110101010101010101010101010101010510101010131344333342342342642564622264RELB13EBOLAEBOLAPtdSerGP112931Filamin BFilamin C


Description

The Ebola virus (EBOV) pathway represents the virus infection on humans, the whole process happens to left to right direction. the initial targets are macrophages and dendritic cells, but the virus has tropisms to infect all kind of cells, with the exception of lymphocytes. Here we represent all cells in general whithin one diagram.

Ebola attachment is made althrough the plasma membrane, after that, a viral glycoprotein induces penetration by endocytosis. This process is made by membranes proteins. During the penetration, Its particles travel in compartments where a viral glycoprotein is cleaved and fused to the endosomal membrane, which results in the uncoation of viral compartments in cytoplasm cell. By this momment the virus make the replication and Host’s imunne down-regulation. During the release process, the newly-created viruses are released from host cell, causing the cell break apart, waiting for the cell to die or by budding off through the cell membrane. Depending on the type of infected cell some trans-infection could happen.

This is the first Ebola pathway construction (under development).

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View approved pathways at the new wikipathways.org.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134288view05:36, 20 July 2024EgonwRemoved a template comment
120623view22:45, 20 December 2021KhanspersModified title
118435view14:40, 27 May 2021Mkutmonfixed publication refs
117706view12:26, 22 May 2021EweitzModified title
101851view14:32, 13 November 2018Elisson nl
101850view14:30, 13 November 2018Elisson nlInteractions correction
98605view20:09, 20 September 2018Elisson nlModified description
98604view19:52, 20 September 2018Elisson nlModified description
98603view19:48, 20 September 2018Elisson nlModification in interactions
98602view19:09, 20 September 2018Elisson nlAnnotated interaction
98332view04:31, 23 August 2018Elisson nlModified description
98331view04:08, 23 August 2018Elisson nlReferences Accentuation Correction
98330view03:54, 23 August 2018Elisson nlReferences Changed
98292view15:35, 16 August 2018DeSlAdded last missing IDs, coloured MHC1 and 2 subunits for clarity 9couldn't find a ID for these groups). Also added a lit. reference describing the effect of LC8 on VP35
98291view15:17, 16 August 2018DeSlAdded more identifiers.
98290view14:57, 16 August 2018DeSlModified description
97372view19:31, 11 May 2018Elisson nlNew References
97362view20:19, 10 May 2018Elisson nlReferences
97361view19:57, 10 May 2018Elisson nlReferences
97360view19:37, 10 May 2018Elisson nlReferences
97357view19:15, 10 May 2018Elisson nlReferences
97356view19:12, 10 May 2018Elisson nlReferences
97353view19:00, 10 May 2018Elisson nlReferences
97351view18:55, 10 May 2018Elisson nlNew References
97327view19:23, 9 May 2018KhanspersOntology Term : 'viral infectious disease' added !
97326view19:22, 9 May 2018KhanspersOntology Term : 'Ebola hemorrhagic fever' added !
97325view19:22, 9 May 2018Khanspersadded xrefs
97170view21:45, 2 May 2018Elisson nlReferences
96845view17:45, 12 April 2018Elisson nlModified description
96805view10:25, 9 April 2018DeSlChanged lines to graphical lines for Ebola virus drawing
96804view10:17, 9 April 2018DeSlAdded IDs from https://www.wikipathways.org/index.php/Pathway:WP4180
96119view02:55, 20 February 2018Elisson nlModified description
96118view02:47, 20 February 2018Elisson nlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTINGeneProductIPR004000 (InterPro)
ACTN1GeneProductENSG00000072110 (Ensembl)
ACTN4GeneProductENSG00000130402 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
ASGR1GeneProductENSG00000141505 (Ensembl)
AXLGeneProductENSG00000167601 (Ensembl)
BST2GeneProductENSG00000130303 (Ensembl)
C1QBPGeneProductENSG00000108561 (Ensembl)
CAV1GeneProductENSG00000105974 (Ensembl)
CAV2GeneProductENSG00000105971 (Ensembl)
CAV3GeneProductENSG00000182533 (Ensembl)
CAVEOLINGeneProductIPR001612 (InterPro)
CD209GeneProductENSG00000090659 (Ensembl)
CD300AGeneProductENSG00000167851 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDC44GeneProductP35251 (Uniprot-TrEMBL) Annotated according to synonimic name with RFC1 according to Uniprot (although not mentioned for Homo sapiens species).
CLATHRINGeneProduct1211 (Entrez Gene)
CLEC10AGeneProductENSG00000132514 (Ensembl)
CLEC4GGeneProductENSG00000182566 (Ensembl)
CLEC4MGeneProductENSG00000104938 (Ensembl)
CLEC6AGeneProductENSG00000205846 (Ensembl)
CLTAGeneProductENSG00000122705 (Ensembl)
CLTBGeneProductENSG00000175416 (Ensembl)
CLTCGeneProductENSG00000141367 (Ensembl)
CLTCL1GeneProductENSG00000070371 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTSBGeneProductENSG00000164733 (Ensembl)
CTSLGeneProductENSG00000135047 (Ensembl)
DAB2IPGeneProductENSG00000136848 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2S1GeneProductENSG00000134001 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
EPS15GeneProductENSG00000085832 (Ensembl)
ERKGeneProduct
F-ACTINGeneProductENSG00000075624 (Ensembl)
FILAMINGeneProduct
FLNAGeneProductENSG00000196924 (Ensembl)
FLNBGeneProductENSG00000136068 (Ensembl)
FLNCGeneProductENSG00000128591 (Ensembl)
FOLR1GeneProductENSG00000110195 (Ensembl)
Filamin AGeneProduct2316 (Entrez Gene)
Filamin BGeneProduct2317 (Entrez Gene)
Filamin CGeneProduct2318 (Entrez Gene)
GAS6GeneProductENSG00000183087 (Ensembl)
GELSOLINGeneProductA0A0A0MS51 (Uniprot-TrEMBL)
GSNGeneProductENSG00000148180 (Ensembl)
HAVCR1GeneProductENSG00000113249 (Ensembl)
HAVCR2GeneProductENSG00000135077 (Ensembl)
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-BGeneProductENSG00000234745 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-DMAGeneProductENSG00000204257 (Ensembl)
HLA-DMBGeneProductENSG00000242574 (Ensembl)
HLA-DOAGeneProductENSG00000204252 (Ensembl)
HLA-DOBGeneProductENSG00000241106 (Ensembl)
HLA-DPA1GeneProductENSG00000231389 (Ensembl)
HLA-DPB1GeneProductENSG00000223865 (Ensembl)
HLA-DQA1GeneProductENSG00000196735 (Ensembl)
HLA-DQA2GeneProductENSG00000237541 (Ensembl)
HLA-DQB1GeneProductENSG00000179344 (Ensembl)
HLA-DQB2GeneProductENSG00000232629 (Ensembl)
HLA-DRAGeneProductENSG00000204287 (Ensembl)
HLA-DRB1GeneProductENSG00000196126 (Ensembl)
HLA-DRB3GeneProduct3125 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProductENSG00000198502 (Ensembl)
HLA-EGeneProductENSG00000204592 (Ensembl)
HLA-FGeneProductENSG00000204642 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
ICAM2GeneProductENSG00000108622 (Ensembl)
ICAM3GeneProductENSG00000076662 (Ensembl)
IGF1RGeneProductENSG00000140443 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IQGAP1GeneProductENSG00000140575 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGA3GeneProductENSG00000005884 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGA5GeneProductENSG00000161638 (Ensembl)
ITGA6GeneProductENSG00000091409 (Ensembl)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
KPNA1GeneProductENSG00000114030 (Ensembl)
LC8GeneProduct8655 (NCBI Protein)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductMAPK3 (HGNC)
MBL2GeneProductENSG00000165471 (Ensembl)
MERTKGeneProductENSG00000153208 (Ensembl)
MFGE8GeneProductENSG00000140545 (Ensembl)
MHC1GeneProduct"In humans, the HLAs corresponding to MHC class I are HLA-A, HLA-B, and HLA-C." https://en.wikipedia.org/wiki/MHC_class_I
MHC2GeneProduct"In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA). HLAs corresponding to MHC class II are HLA-DP, HLA-DM, HLA-DOA, HLA-DOB, HLA-DQ, and HLA-DR." https://en.wikipedia.org/wiki/MHC_class_II
NEDD4GeneProductENSG00000069869 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NFKBGeneProductENSG00000109320 (Ensembl)
NPC1GeneProductENSG00000141458 (Ensembl)
NPC2GeneProductENSG00000119655 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIK3RGeneProductENSG00000145675 (Ensembl)
PP1GeneProduct3.1.3.16 (Enzyme Nomenclature)
PRKRAGeneProductENSG00000180228 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB7AGeneProductENSG00000075785 (Ensembl)
RAB9AGeneProductENSG00000123595 (Ensembl) PUBMED
RAC1GeneProductENSG00000136238 (Ensembl)
RASA2GeneProductENSG00000155903 (Ensembl)
RELGeneProduct5966 (Entrez Gene)
RELAGeneProductENSG00000173039 (Ensembl)
RELBGeneProductENSG00000104856 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
RHOBGeneProductENSG00000143878 (Ensembl)
RHOCGeneProductENSG00000155366 (Ensembl)
SCINGeneProductENSG00000006747 (Ensembl)
SOCS3GeneProductENSG00000184557 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TIAM1GeneProductENSG00000156299 (Ensembl)
TIMD4GeneProductENSG00000145850 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TOP1GeneProductENSG00000198900 (Ensembl)
TPCN2GeneProductENSG00000162341 (Ensembl)
TSG101GeneProductENSG00000074319 (Ensembl)
TYRO3GeneProductENSG00000092445 (Ensembl)
VAV2GeneProductENSG00000160293 (Ensembl)
VPS11GeneProductENSG00000160695 (Ensembl)
VPS16GeneProductENSG00000215305 (Ensembl)
VPS18GeneProductENSG00000104142 (Ensembl)
VPS33AGeneProductENSG00000139719 (Ensembl)
VPS39GeneProductENSG00000166887 (Ensembl)
VPS41GeneProductENSG00000006715 (Ensembl)
VPS4AGeneProductENSG00000132612 (Ensembl)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADAM17Exit of Secreted GPArrow13 (Other) PUBMED
ASGR1GPmim-binding65 (Other) PUBMED
AXLGAS6mim-stimulation27 (Other) PUBMED
BST2Assembly and BuddingTBar33 (Other) PUBMED
C1QBPmim-binding46 (Other) PUBMED
CD209GPmim-binding32 (Other) PUBMED
CD300APtdSermim-binding68 (Other) PUBMED
CDC42mim-necessary-stimulation6 (Other) PUBMED
CLATHRIN62 (Other) PUBMED
CLATHRIN63 (Other) PUBMED
CLATHRIN64 (Other) PUBMED
CLEC10AGPmim-binding31 (Other) PUBMED
CLEC4GGPmim-binding42 (Other) PUBMED
CLEC6AGPmim-binding47 (Other) PUBMED
CREBBP57 (Other) PUBMED
CTSBEBOLAArrow2 (Other) PUBMED
CTSLEBOLAArrow3 (Other) PUBMED
EBOLANPC1Arrow4 (Other) PUBMED
EGFRGPmim-stimulation11 (Other) PUBMED
EIF2AK2EIF2S1Arrow72 (Other) PUBMED
ERK1 (Other) PUBMED
F-ACTINmim-stimulation7 (Other) PUBMED
FOLR1GPmim-binding24 (Other) PUBMED
GAS6PtdSermim-necessary-stimulation26 (Other) PUBMED
GP1,2ITGA1TBar19 (Other) PUBMED
GP1,2ITGA2TBar23 (Other) PUBMED
GP1,2ITGA3TBar22 (Other) PUBMED
GP1,2ITGA4TBar20 (Other) PUBMED
GP1,2ITGA5TBar21 (Other) PUBMED
GP1,2ITGA6TBar18 (Other) PUBMED
GP1,2ITGB1TBar17 (Other) PUBMED
HAVCR1TIMD4mim-stimulation37 (Other) PUBMED
HAVCR2mim-binding36 (Other) PUBMED
IGF1RPIK3Rmim-binding67 (Other) PUBMED
IKBKEIRF7Arrow38 (Other) PUBMED
IL4CLEC4Gmim-stimulation41 (Other) PUBMED
IQGAP1Arrow43 (Other) PUBMED
ITGAVmim-binding16 (Other) PUBMED
ITGB3mim-binding15 (Other) PUBMED
Interferon Response44 (Other) PUBMED
Interferon Response58 (Other) PUBMED
Interferon ResponseCREBBP59 (Other) PUBMED
Interferon ResponseSTAT154 (Other) PUBMED
KPNA1STAT1TBar40 (Other) PUBMED
MBL2GPmim-stimulation45 (Other) PUBMED
MERTKGAS6mim-stimulation28 (Other) PUBMED
MFGE8PtdSermim-necessary-stimulation14 (Other) PUBMED
NEDD4Arrow51 (Other) PUBMED
NPC2NPC1Arrow5 (Other) PUBMED
PAK1CDC42mim-binding8 (Other) PUBMED
PAK1mim-binding12 (Other) PUBMED
PIK3RAKT1mim-binding66 (Other) PUBMED
PRKRADDX58Arrow70 (Other) PUBMED
RAB5ALysosomeArrow9 (Other) PUBMED
RAB7ARAB5AArrow10 (Other) PUBMED
RHOBmim-binding56 (Other) PUBMED
RHOCmim-binding55 (Other) PUBMED
SOCS3TLR4Arrow52 (Other) PUBMED
TBK1IRF3Arrow39 (Other) PUBMED
TIMD4PtdSermim-necessary-stimulation35 (Other) PUBMED
TLR4Cytokine SignalArrow53 (Other) PUBMED
TPCN2Transcription, Translation and ReplicationArrow48 (Other) PUBMED
TSG101Arrow49 (Other) PUBMED
TYRO3GAS6mim-stimulation25 (Other) PUBMED
Trans-InfectionICAM2Arrow30 (Other) PUBMED
Trans-InfectionICAM3Arrow29 (Other) PUBMED
Trans-InfectionMHC1Arrow61 (Other) PUBMED
Trans-InfectionMHC2Arrow60 (Other) PUBMED
VP35EIF2AK2TBar71 (Other) PUBMED
VP35PRKRATBar69 (Other) PUBMED
VPS4AArrow50 (Other) PUBMED
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