Glycolysis and gluconeogenesis - for workshop (Homo sapiens)

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1GluconeogenesisGlycolysisSLC2A3Fructose-1,6BPFBP1LactatePyruvateMDH1PGAM2GlucosePFKLHK32P-GlycerateGlyceraldehyde 3P3P-GlycerateLDHASLC2A5Triglyceride synthesisSLC2A1ALDOCPGK2Pentose Phosphate PathwayGCKENO2MPC2GOT1ENO3MalateHK2SLC2A4LDHCPKM2Glucose-6PPFKPENO1PyruvateFBP2SLC2A2MPC1PKM2LDHAL6BPGK1Glycogen metabolism1,3BP-GlycerateGlucosePFKMAspartateDihydroxyacetone-PALDOBP-enolpyruvateLDHBGAPDHPCK1OxaloacetateGAPDHSTPI1PGAM1HK1Fructose 6PALDOAG6PCPKLRGlucose-6P (open)PGIFructose 6P (open)GPI


Description

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the ATP and NADH.

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids.

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Ontology Terms

 

Bibliography

  1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128073view00:42, 24 January 2024EweitzModified title
110562view16:58, 18 May 2020KhanspersModified description
109919view17:14, 6 April 2020KhanspersModified description
107170view14:25, 17 September 2019MaintBotChEBI identifier normalization
106800view13:28, 17 September 2019MaintBotHMDB identifier normalization
98730view23:31, 2 October 2018Khanspersupdated complexes
98728view23:14, 2 October 2018Khanspersfine tuning
98726view20:22, 2 October 2018KhanspersModified description
98725view20:22, 2 October 2018KhanspersModified description
98724view20:21, 2 October 2018KhanspersModified title
98723view20:21, 2 October 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1,3BP-GlycerateMetaboliteHMDB01270 (HMDB)
2P-GlycerateMetaboliteHMDB00362 (HMDB)
3P-GlycerateMetaboliteHMDB00807 (HMDB)
ALDOAGeneProduct226 (Entrez Gene)
ALDOBGeneProduct229 (Entrez Gene)
ALDOCGeneProduct230 (Entrez Gene)
AspartateMetaboliteHMDB00191 (HMDB)
Dihydroxyacetone-PMetaboliteHMDB01473 (HMDB)
ENO1GeneProduct2023 (Entrez Gene)
ENO2GeneProduct2026 (Entrez Gene)
ENO3GeneProduct2027 (Entrez Gene)
FBP1GeneProduct2203 (Entrez Gene)
FBP2GeneProduct8789 (Entrez Gene)
Fructose 6P (open)MetaboliteCHEBI:57579 (ChEBI) fructose-6-phosphate (2-) open form
Fructose 6PMetabolite61527 (ChEBI)
Fructose-1,6BPMetaboliteHMDB01058 (HMDB)
G6PCGeneProduct2538 (Entrez Gene) Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway
GAPDHGeneProductENSG00000111640 (Ensembl)
GAPDHSGeneProduct26330 (Entrez Gene)
GCKGeneProduct2645 (Entrez Gene) Gck is mainly active in liver
GOT1GeneProduct2805 (Entrez Gene)
GPIGeneProduct2821 (Entrez Gene) glucose-6-phosphate isomerase
Glucose-6P (open)MetaboliteCHEBI:57584 (ChEBI) D-Glucose-6-Phosphate (2-) open form
Glucose-6PMetaboliteCHEBI:75052 (ChEBI) Glucose-6-Phosphate (2-)
GlucoseMetaboliteHMDB00122 (HMDB)
Glyceraldehyde 3PMetaboliteHMDB01112 (HMDB)
Glycogen metabolismPathwayWP500 (WikiPathways)
HK1GeneProduct3098 (Entrez Gene)
HK2GeneProduct3099 (Entrez Gene)
HK3GeneProduct3101 (Entrez Gene)
LDHAGeneProduct3939 (Entrez Gene)
LDHAL6BGeneProduct92483 (Entrez Gene)
LDHBGeneProduct3945 (Entrez Gene)
LDHCGeneProduct3948 (Entrez Gene)
LactateMetaboliteHMDB00190 (HMDB)
MDH1GeneProduct4190 (Entrez Gene)
MPC1GeneProduct51660 (Entrez Gene)
MPC2GeneProduct25874 (Entrez Gene)
MalateMetaboliteHMDB00744 (HMDB)
OxaloacetateMetaboliteHMDB00223 (HMDB)
P-enolpyruvateMetaboliteHMDB00263 (HMDB)
PCK1GeneProduct5105 (Entrez Gene)
PFKLGeneProduct5211 (Entrez Gene)
PFKMGeneProduct5213 (Entrez Gene)
PFKPGeneProduct5214 (Entrez Gene)
PGAM1GeneProduct5223 (Entrez Gene)
PGAM2GeneProduct5224 (Entrez Gene)
PGIGeneProduct5.3.1.9 (Enzyme Nomenclature) phosphoglucose isomerase (PGI)
PGK1GeneProduct5230 (Entrez Gene)
PGK2GeneProduct5232 (Entrez Gene)
PKLRGeneProduct5313 (Entrez Gene)
PKM2GeneProduct5315 (Entrez Gene)
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
PyruvateMetaboliteHMDB00243 (HMDB)
SLC2A1GeneProduct6513 (Entrez Gene)
SLC2A2GeneProduct6514 (Entrez Gene)
SLC2A3GeneProduct6515 (Entrez Gene)
SLC2A4GeneProduct6517 (Entrez Gene)
SLC2A5GeneProduct6518 (Entrez Gene)
TPI1GeneProduct7167 (Entrez Gene)
Triglyceride synthesisPathwayWP325 (WikiPathways)

Annotated Interactions

No annotated interactions

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