Isoprenoid precursor biosynthesis in Pf apicoplasts (Plasmodium falciparum)
From WikiPathways
Description
This pathway shows a apicoplast of the Plasmodium falciparum that infected a human cell. The human glycolysis provides the apicoplast with nutrients for its isoprenoid precursor biosynthesis. This pathway is being investigated for targets for malaria drug leads and drugs.
Quality Tags
Ontology Terms
Bibliography
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- Yao ZK, Krai PM, Merino EF, Simpson ME, Slebodnick C, Cassera MB, Carlier PR; ''Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies.''; Bioorg Med Chem Lett, 2015 PubMed Europe PMC Scholia
- Yeh E, DeRisi JL; ''Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.''; PLoS Biol, 2011 PubMed Europe PMC Scholia
- Hunter WN; ''The non-mevalonate pathway of isoprenoid precursor biosynthesis.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
- Hunter WN; ''Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites.''; Curr Top Med Chem, 2011 PubMed Europe PMC Scholia
- Wiemer AJ, Hsiao CH, Wiemer DF; ''Isoprenoid metabolism as a therapeutic target in gram-negative pathogens.''; Curr Top Med Chem, 2010 PubMed Europe PMC Scholia
- Wu W, Herrera Z, Ebert D, Baska K, Cho SH, DeRisi JL, Yeh E; ''A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis.''; Antimicrob Agents Chemother, 2015 PubMed Europe PMC Scholia
- Borrmann S, Lundgren I, Oyakhirome S, Impouma B, Matsiegui PB, Adegnika AA, Issifou S, Kun JF, Hutchinson D, Wiesner J, Jomaa H, Kremsner PG; ''Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria.''; Antimicrob Agents Chemother, 2006 PubMed Europe PMC Scholia
- Borrmann S, Adegnika AA, Matsiegui PB, Issifou S, Schindler A, Mawili-Mboumba DP, Baranek T, Wiesner J, Jomaa H, Kremsner PG; ''Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children.''; J Infect Dis, 2004 PubMed Europe PMC Scholia
- Ruangweerayut R, Looareesuwan S, Hutchinson D, Chauemung A, Banmairuroi V, Na-Bangchang K; ''Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria.''; Malar J, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
2-methyl-2-(E)-butenyl diphosphate | Metabolite | ||
CDP-ME | Metabolite | CHEBI:16578 (ChEBI) | 4-Diphosphocytidyl-2-C-methylerythritol |
CDP-MEP | Metabolite | 443200 (PubChem-compound) | 4-Diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate |
D-Glyceraldehyde 3-phosphate | Metabolite | HMDB01112 (HMDB) | |
DMAPP | Metabolite | 647 (PubChem-compound) | Minor product. |
DOXP | Metabolite | CHEBI:57792 (ChEBI) | 1-deoxy-D-xylulose 5-phosphate |
DXS | GeneProduct | 813741 (Entrez Gene) | |
Glycerone-P | Metabolite | CHEBI:16108 (ChEBI) | |
Glycolysis | Pathway | WP534 (WikiPathways) | |
IPP | Metabolite | 1195 (PubChem-compound) | |
IspC | GeneProduct | 812223 (Entrez Gene) | |
IspD | GeneProduct | PFA0340w (Ensembl) | PF3D7_0106900; PFA0340w; .7.7.60 |
IspE | GeneProduct | A0A1D3U940 (Uniprot-TrEMBL) | |
IspF | GeneProduct | A0A1D3RDA4 (Uniprot-TrEMBL) | |
IspG | GeneProduct | Q9BJX5 (Uniprot-TrEMBL) | |
IspH | GeneProduct | IPR003451 (InterPro) | |
MEPC | Metabolite | 126747 (PubChem-compound) | 4-Diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate |
MEP | Metabolite | CHEBI:58262 (ChEBI) | 2C-methyl-D-erythritol 4-phosphate |
MMV008138 | Metabolite | 987146 (PubChem-compound) | |
PEP/Pi translocator | GeneProduct | 813115 (Entrez Gene) | |
Phosphoenolpyruvic acid | Metabolite | HMDB00263 (HMDB) | |
Triose-P/Pi translocator | GeneProduct | 812861 (Entrez Gene) | |
fosmidomycin | Metabolite | 555 (Chemspider) | |
pyruvate | Metabolite | CHEBI:15361 (ChEBI) |
Annotated Interactions
No annotated interactions