Sucrose biosynthesis (Saccharomyces cerevisiae)

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1H2OUDPUDP-D-glucoseH2OUDPSucrose-6-phosphatefructose-1,6-bisphosphateUTPFBP1fructose-6-phosphateYHL012Wpyrophosphatephosphatefructoseglucose-6-phosphatesucroseADPATPPGI1phosphatefructose-6-phosphateglucose-1-phosphatePGM1fructosePGM2UGP1


Description

Sucrose is synthesized from the precursors UDP-glucose and fructose 6-phosphate, which are converted into sucrose 6-phosphate by the enzyme sucrose-6-phosphate synthase. Sucrose 6-phosphate is then dephosphorylated by sucrose phosphatase, resulting in the formation of sucrose, which can be exported to other tissues. Although the reaction catalyzed by sucrose 6-phosphate synthase is energetically unfavorable, the hydrolysis of sucrose 6-phosphate to sucrose is highly exergonic, driving the overall synthesis of sucrose in an essentially irreversible manner.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Marques WL, Raghavendran V, Stambuk BU, Gombert AK; ''Sucrose and Saccharomyces cerevisiae: a relationship most sweet.''; FEMS Yeast Res, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134135view13:36, 30 June 2024EgonwAdded a review about sucrose in this species from 2016
134134view13:34, 30 June 2024EgonwUnbolded several datanode labels
125514view02:18, 24 February 2023AlexanderPicoadded description
117341view11:51, 20 May 2021EweitzModified title
96403view11:03, 12 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier (I missed one, it seems).
96368view07:30, 10 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
93725view15:49, 14 August 2017DeSlChanged incorrect ID for glucose-1-phosphate
93724view15:47, 14 August 2017DeSlChanged textlabels to metabolite nodes, annotated them, connected lines.
69669view20:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
67664view11:46, 26 June 2013DdiglesOntology Term : 'sucrose biosynthetic pathway' added !
58992view19:41, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
53537view19:49, 8 November 2012EgonwMarked several DataNode's as Metabolite.
41912view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
29887view11:14, 9 June 2009Thomasupdated ensembl references
20701view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Sucrose Biosynthesis]] moved to [[Pathway:WP14]]: Moved to stable identifier
12851view08:05, 17 May 2008MaintBotautomated metabolite conversion
10999view20:22, 2 March 2008MaintBotyeast id converter
10265view23:56, 18 January 2008AlexanderPicomanually update IDs to work with new database
8933view14:12, 7 January 2008MaintBotAdded to category $category
8931view14:12, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
FBP1GeneProductFBP1 (SGD)
H2OMetaboliteCHEBI:15377 (ChEBI)
PGI1GeneProductPGI1 (SGD)
PGM1GeneProductPGM1 (SGD)
PGM2GeneProductPGM2 (SGD)
Sucrose-6-phosphateMetaboliteCHEBI:131603 (ChEBI)
UDP-D-glucoseMetaboliteCHEBI:18066 (ChEBI)
UDPMetaboliteCHEBI:17659 (ChEBI)
UGP1GeneProductUGP1 (SGD)
UTPMetaboliteCHEBI:15713 (ChEBI)
YHL012WGeneProductYHL012W (Ensembl)
fructose-1,6-bisphosphateMetabolite
fructose-6-phosphateMetabolite643-13-0 (CAS)
fructoseMetabolite7776-48-9 (CAS)
glucose-1-phosphateMetaboliteCHEBI:16077 (ChEBI)
glucose-6-phosphateMetabolite59-56-3 (CAS)
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)
sucroseMetabolite57-50-1 (CAS)

Annotated Interactions

No annotated interactions

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