Nuclear receptors meta-pathway (Homo sapiens)

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14, 34CAR/PXR LigandOtherOtherOtherOtherOtherCAR target genes3212532ESR1UGT1A7PPARAHSP90AA1SULT2A1ALOX5APCBR3SERPINB9PTGR1IL12BCES4ATXNABCC4TSC22D3SMARCA1AntioxidantproteinsHSP90AB1SQSTM1CES1PDK4CYP2B6HBEGFKTN1NR0B2ABCC2ABCB4GSTA2SLC2A11ABCC5UGT1A9ALAS1CYP1A1STAT3GSTA4Co-activatorsMFGE8GSTP1MAFGCYP2C9PMP2PPARGC1AJUNCYP2A6TNFAIP3CYP7A1MGST2FGD4PRDX1TranscriptionfactorsSNAI2ABCG5SLC2A12CAP2ARL5BKEAP1SLC7A5PGDCDKN1CSERPINB2UGT1A9SLC27A5HMOX1GSTA2MAFFME1GSTA1FTLTGFAUGT1A3FGFBP1CYP2A6FASNRGS2UGT1A3MYOFBIRC2SULT2A1G6PDMGST1SLC2A9SREBF1Bile acid &xenobiotics transportRXRACYP3A4PPARDNR0B2SLC2A6SRGNIL17BNQO1CBR1MGST3NCOA6B3GNT5PRRG4BIRC3ABCC3EGR1UGT1A3ABCB11NFE2L2SLC7A11EP300FGF13Cell proliferationand apoptosisDrug and steroidmetabolismSLC2A3CUL1IL12AJUNBTHBDCES3DNAJC7UGT2B7IFNGTGFBR2POLKS100PSULT1A1EPB41L4BCYP2C19GCLCIRS2UGT1A6CES5AGSTA3IL11SOD3CCL2ABCG8DNERBile acidneosynthesisGSTT1PDGFBCell proliferationand differentiationUGT1A4AMIGO2UGT1A6CYP7A1JUNANGPTL4ABCC2NCOA2SERPINA1EDN2CCL20NR0B2HGFPDE4BAGERZIC2GSTT2NAV3GCC1SLC2A10IL1BPPARAGPX2Phase 2metabolismCPEB4PLK2CYP3A7UGT1A1GPR153SLC19A2CES2NR1H4SP1SRXN1SLC2A7EPHA3BHLHE40CXCR7MGAMNCOA1HSPA1ASLC2A1ABHD2BAATTGFBR3ACAA1TXNRD3CYP1B1SCNN1ACYP7A1SLC10A1UGT1A7GSRPRDX6CYP8B1SLC2A4SLC2A2NR3C1GCLMUGT1A9CYP2A6SRCNRG1FTH1ABCC3UGT1A4SLC2A13NFKB2UGT1A1FKBP5SULT2A1TGFB2ENC1UGT2B4ALDH3A1ABCB1SLC2A14TNS4CYP2B6UGT1A4LRRC8ACYP4A11PTGS2POU5F1KAT2BAKAP13PCK1SLCO2B1GSTA5PPARGC1Abile acidconjugationMT1IPPPP2R4CYP3A4BLVRBFGF19SP1SERTAD2SLC26A2GGT1SLC2A5CYP4A11DNAJB1SMC1AHSP90AA1ACOX1SPRY1SDPRADH7STOMEHHADHGPR115TranscriptionfactorsGPAMNR1I3ETNK2DNAJC15CYP3A4PPP1R14CIP6K3CYP3A5GADD45BInflammationNR1H3CYP1A2SPINK13TGFB1CES3MetabolismEPHA2ANKRD1CDC42EP3TGFB1SLC2A8SEC14L1GPX3TXNRD129333348484022222247483403161134328401621, 241339816283384216816401516216161473347221651403522NR1I35397322282216331611351611162228411164638316LigandDNAJC7HSP90AA1CoregulatorsGenesTATA boxPBREMRXRANR1I3LigandCo-activatorsNCOA1EGFR pathwayEP300UGT1A6AHRR3, 16, 19SRC40CDKN1B40AIPCYP1B1UGT1A13, 19, 35, 40, 473, 16, 19ALDH3A147GSTA23, 19AHRJUNDNQO1313, 19IGFBP120NFE2L219BAXJUN40CYP1A2493, 19, 35, 40, 47EGFRHSP90AA1TNFPTGES3IL217HES16ARNTCDC37CYP1A13, 19, 35, 40, 47AHRARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxUGT1A9Hepatocyteproliferation16, 29NR1H329SCP229CPT1A29APOC329FABP129CCND129PLTP29DBI29APOA229CPT229APOA129CYP4A1129ACADMCDK429CYP7A12929MYC29mitochondrialomega-oxidationSLC27A129Cholesterolcatabolismperoxisomalbeta-oxidationKLK1529APOA529CDK1CYP8B129PPAR alpha ligand29PPARAGenesTATA boxPPREPPARARXRALigandlipoproteinmetabolismfatty acidtransportmitochondrialbeta-oxidationPXR target genes9, 28SLCO1B19HSP90AA1NR1I2SRPX2NCOA3FOXO145CYP4F12CYP3A49UGT1A139DNAJC7ABCC49NRIP1UnknownCYP2B63GSTA29PSMC5PPARGC1ANCOA1NCOA2ABCB19NR1I2LigandCoregulatorsGenesTATA boxXRERXRANR1I2LigandAhR LigandCo-activatorsGenesTATA boxNR1I3NR1I2NR3C1RXRA21, 24NR1I3NR1I2NR3C1HSP90AA1GR ligandp23HSP90AA1p23NR3C1HSP90AA136, 43p23NR3C1Ligand43NR3C143LigandLigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGRECoregulatorsGR inhibitorytarget genesLXR ligandNR1H3LigandRXRA21, 24PTGES3RXRA21, 24NR1H3CYP2B6CYP2C92222GenesTATA boxVDREVDR target genesVDR26, 43LigandRXRACYP3A422VDRVDR ligandRXRAVDRLigandER ligandESR1ESR1LigandLigandGenesTATA boxEREESR1LigandESR1LigandESR141ESR1ESR1LigandLigandCoregulatorsER target genes18GenesTATA boxNR1H3LigandLXRERXRA21, 24LXR target genesFXR ligandNR1H451RXRALigandGenesTATA boxNR1H4RXRA51LigandFXREBile aciddetoxification8NR1H451LigandUGT1A4UGT1A61616UGT1A9UGT1A316CYP2C916CYP3A53CYP2C193SULT2A13ABCC2522ABCC322EHHADHFOXO13345Inflammation32Growth andapoptosis32Signaltransduction32Inflammation32Growth andapoptosis32SignaltransductionMetabolism32Transport3232NuclearreceptorsFXR Target genesGR stimulatorytarget genesMulti-drugresistanceDrug and steroidmetabolismPhase 2metabolismMulti-drugresistancePhase 2metabolismDrug and steroidmetabolismPhase 2metabolismDrug and steroidmetabolismMulti-drugresistanceTranscriptionfactorsDrug and steroidmetabolismTranscriptionfactorsDrug and steroidmetabolismPPAR alphatarget genesAhR target genesGenesTATA boxRXRALigandARENRF2 targetgenesPhase 1proteinsPhase 2proteins1GSTM51GSTM1GSTM2GSTM3GSTM4Transport1SLC5A2SLC5A1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SLC5A8SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14Growth factorsand receptorsNFE2L21NRF2 ligandKEAP1NFE2L2LigandNFE2L2NFE2L2SCDOtherOtherOtherOtherOther


Description

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism.

Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors generally only happens when a ligand is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor, which, in turn, activates the receptor, resulting in up- or down-regulation of gene expression.

A unique property of nuclear receptors that differentiates them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. As a consequence, nuclear receptors play key roles in both embryonic development and adult homeostasis. Nuclear receptors may be classified according to either mechanism or homology.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
126680view16:51, 11 June 2023EgonwFixed character encoding issues
126012view11:37, 26 March 2023EgonwWrong ligand term
125859view10:46, 13 March 2023DeSlFixed last 'ligand' classified as protein
125858view10:44, 13 March 2023DeSlResolved typo in description
125857view10:43, 13 March 2023DeSlRemoved empty comment from Description
125856view10:42, 13 March 2023DeSlConnected unconnected line
125855view10:41, 13 March 2023DeSlConverted textLabels 'ligand; to DataNode Metabolite, with ChEBI annotation; changed two protein datanodes to metaboliute for ligand.
125833view07:00, 13 March 2023EgonwAdded ChEBI identifiers for ligands
120815view15:30, 11 January 2022SusanOntology Term : 'transcription factor mediated signaling pathway' added !
117808view14:40, 22 May 2021EweitzModified title
115341view14:20, 14 February 2021EgonwMade more pathways clickable
103038view11:54, 2 February 2019MaintBotReplaced an outdated Ensembl identifiers with the new one.
97489view13:23, 23 May 2018Fehrhartlayout
97488view13:17, 23 May 2018Fehrhartadded annotations
97487view13:08, 23 May 2018Fehrhartadded annotations
97484view12:58, 23 May 2018FehrhartModified description
97483view12:56, 23 May 2018Fehrhartadded annotations
97481view12:50, 23 May 2018Fehrhartadded annotations
97480view12:42, 23 May 2018Fehrhartadded annotations
97479view12:35, 23 May 2018Fehrhartadded annotations
97478view12:12, 23 May 2018FehrhartModified description
97477view12:11, 23 May 2018FehrhartModified description
97476view12:07, 23 May 2018Fehrhartall connections done (hopefully)
97475view12:04, 23 May 2018Fehrhartconnections
97474view12:02, 23 May 2018Fehrhartconnections...
97473view12:00, 23 May 2018Fehrhartfixed connections
97472view11:58, 23 May 2018Fehrhartfixed connections
97471view11:56, 23 May 2018Fehrhartfixed connections
97470view11:55, 23 May 2018Fehrhartfixed more connections
97469view11:53, 23 May 2018Fehrhartfixed more connections
97467view09:20, 23 May 2018Fehrhartfixed more connections
97463view08:48, 22 May 2018Fehrhartfixed connections
87959view13:12, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
83040view04:29, 18 November 2015Mkutmonfixed issue with references
83016view13:30, 17 November 2015FehrhartUpdate of outdated identifiers
79825view08:28, 17 April 2015EgonwFixed the Ensembl data source.
78569view14:50, 7 January 2015MaintBotadded missing graphIds
78210view14:44, 14 December 2014EgonwChanged schema.
78209view14:42, 14 December 2014MaintBotModified title
78095view11:38, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB11GeneProductENSG00000073734 (Ensembl)
ABCB1GeneProductENSG00000085563 (Ensembl)
ABCB4GeneProductENSG00000005471 (Ensembl)
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
ABCC5GeneProductENSG00000114770 (Ensembl)
ABCG5GeneProductENSG00000138075 (Ensembl)
ABCG8GeneProductENSG00000143921 (Ensembl)
ABHD2GeneProductENSG00000140526 (Ensembl)
ACAA1GeneProductENSG00000060971 (Ensembl)
ACADMGeneProductENSG00000117054 (Ensembl)
ACOX1GeneProductENSG00000161533 (Ensembl)
ADH7GeneProductENSG00000196344 (Ensembl)
AGERGeneProductENSG00000204305 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
AHRRGeneProductENSG00000063438 (Ensembl)
AIPGeneProductENSG00000110711 (Ensembl)
AKAP13GeneProductENSG00000170776 (Ensembl)
ALAS1GeneProductENSG00000023330 (Ensembl)
ALDH3A1GeneProductENSG00000108602 (Ensembl)
ALOX5APGeneProductENSG00000132965 (Ensembl)
AMIGO2GeneProductENSG00000139211 (Ensembl)
ANGPTL4GeneProductENSG00000167772 (Ensembl)
ANKRD1GeneProductENSG00000148677 (Ensembl)
APOA1GeneProductENSG00000118137 (Ensembl)
APOA2GeneProductENSG00000158874 (Ensembl)
APOA5GeneProductENSG00000110243 (Ensembl)
APOC3GeneProductENSG00000110245 (Ensembl)
ARL5BGeneProductENSG00000165997 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
Antioxidant proteinsPathwayWP408 (WikiPathways)
B3GNT5GeneProductENSG00000176597 (Ensembl)
BAATGeneProductENSG00000136881 (Ensembl)
BAX GeneProductENSG00000087088 (Ensembl)
BHLHE40GeneProductENSG00000134107 (Ensembl)
BIRC2GeneProductENSG00000110330 (Ensembl)
BIRC3GeneProductENSG00000023445 (Ensembl)
BLVRBGeneProductENSG00000090013 (Ensembl)
Bile acid detoxificationPathwayWP1788 (WikiPathways)
Bile acid neosynthesisPathwayWP1788 (WikiPathways)
Bile acid & xenobiotics transportPathwayWP1788 (WikiPathways)
CAP2GeneProductENSG00000112186 (Ensembl)
CBR1GeneProductENSG00000159228 (Ensembl)
CBR3GeneProductENSG00000159231 (Ensembl)
CCL20GeneProductENSG00000115009 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDC37GeneProductENSG00000105401 (Ensembl)
CDC42EP3GeneProductENSG00000163171 (Ensembl)
CDK1GeneProductENSG00000170312 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CDKN1CGeneProductENSG00000129757 (Ensembl)
CES1GeneProductENSG00000198848 (Ensembl)
CES2GeneProductENSG00000172831 (Ensembl)
CES3GeneProductENSG00000172828 (Ensembl)
CES4AGeneProductENSG00000172824 (Ensembl)
CES5AGeneProductENSG00000159398 (Ensembl)
CPEB4GeneProductENSG00000113742 (Ensembl)
CPT1AGeneProductENSG00000110090 (Ensembl)
CPT2GeneProductENSG00000157184 (Ensembl)
CUL1GeneProductENSG00000055130 (Ensembl)
CXCR7GeneProductENSG00000144476 (Ensembl)
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP1B1GeneProductENSG00000138061 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP3A5GeneProductENSG00000106258 (Ensembl)
CYP3A7GeneProductENSG00000160870 (Ensembl)
CYP4A11GeneProductENSG00000187048 (Ensembl)
CYP4F12GeneProductENSG00000186204 (Ensembl)
CYP7A1GeneProductENSG00000167910 (Ensembl)
CYP8B1GeneProductENSG00000180432 (Ensembl)
Cell proliferation and apoptosisPathwayWP179 (WikiPathways)
Cell proliferation and differentiationPathwayWP2029 (WikiPathways)
Cholesterol catabolismPathwayWP4190 (WikiPathways)
Co-activators
DBIGeneProductENSG00000155368 (Ensembl)
DNAJB1GeneProductENSG00000132002 (Ensembl)
DNAJC15GeneProductENSG00000120675 (Ensembl)
DNAJC7GeneProductENSG00000168259 (Ensembl)
DNERGeneProductENSG00000187957 (Ensembl)
Drug and steroid metabolismPathwayWP496 (WikiPathways)
EDN2GeneProductENSG00000127129 (Ensembl)
EGFR pathwayPathwayWP1910 (WikiPathways)
EGFRGeneProductENSG00000146648 (Ensembl)
EGR1GeneProductENSG00000120738 (Ensembl)
EHHADHGeneProductENSG00000113790 (Ensembl)
ENC1GeneProductENSG00000171617 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
EPB41L4BGeneProductENSG00000095203 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
EPHA3GeneProductENSG00000044524 (Ensembl)
ESR1GeneProductENSG00000091831 (Ensembl)
ETNK2GeneProductENSG00000143845 (Ensembl)
FABP1GeneProductENSG00000163586 (Ensembl)
FASNGeneProductENSG00000169710 (Ensembl)
FGD4GeneProductENSG00000139132 (Ensembl)
FGF13GeneProductENSG00000129682 (Ensembl)
FGF19GeneProductENSG00000162344 (Ensembl)
FGFBP1GeneProductENSG00000137440 (Ensembl)
FKBP5GeneProductENSG00000096060 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FTH1GeneProductENSG00000167996 (Ensembl)
FTLGeneProductENSG00000087086 (Ensembl)
G6PDGeneProductENSG00000160211 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GCC1GeneProductENSG00000179562 (Ensembl)
GCLCGeneProductENSG00000001084 (Ensembl)
GCLMGeneProductENSG00000023909 (Ensembl)
GGT1GeneProductENSG00000100031 (Ensembl)
GPAMGeneProductENSG00000119927 (Ensembl)
GPR115GeneProductENSG00000153294 (Ensembl)
GPR153GeneProductENSG00000158292 (Ensembl)
GPX2GeneProductENSG00000176153 (Ensembl)
GPX3GeneProductENSG00000211445 (Ensembl)
GSRGeneProductENSG00000104687 (Ensembl)
GSTA1GeneProductENSG00000243955 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
GSTA3GeneProductENSG00000174156 (Ensembl)
GSTA4GeneProductENSG00000170899 (Ensembl)
GSTA5GeneProductENSG00000182793 (Ensembl)
GSTM1GeneProductENSG00000134184 (Ensembl)
GSTM2GeneProductENSG00000213366 (Ensembl)
GSTM3GeneProductENSG00000134202 (Ensembl)
GSTM4GeneProductENSG00000168765 (Ensembl)
GSTM5GeneProductENSG00000134201 (Ensembl)
GSTP1GeneProductENSG00000084207 (Ensembl)
GSTT1GeneProductENSG00000277656 (Ensembl)
GSTT2GeneProductENSG00000099984 (Ensembl)
Growth and apoptosisPathwayWP2657 (WikiPathways)
Growth factors and receptorsPathwayWP2657 (WikiPathways)
HBEGFGeneProductENSG00000113070 (Ensembl)
HES1GeneProductENSG00000114315 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl)
HMOX1GeneProductENSG00000100292 (Ensembl)
HSP90AA1 GeneProductENSG00000080824 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
HSP90AB1GeneProductENSG00000096384 (Ensembl)
HSPA1AGeneProductENSG00000204389 (Ensembl)
Hepatocyte proliferationPathwayWP313 (WikiPathways) in mice (possibly also in humans?)
IFNGGeneProductENSG00000111537 (Ensembl)
IGFBP1 GeneProductENSG00000146678 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL17BGeneProductENSG00000127743 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL2 GeneProductENSG00000109471 (Ensembl)
IP6K3GeneProductENSG00000161896 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
InflammationPathwayWP453 (WikiPathways)
JUNBGeneProductENSG00000171223 (Ensembl)
JUNDGeneProductENSG00000130522 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
KAT2BGeneProductENSG00000114166 (Ensembl)
KEAP1GeneProductENSG00000079999 (Ensembl)
KLK15GeneProductENSG00000174562 (Ensembl)
KTN1GeneProductENSG00000126777 (Ensembl)
LRRC8AGeneProductENSG00000136802 (Ensembl)
LigandMetaboliteQ899107 (Wikidata)
MAFFGeneProductENSG00000185022 (Ensembl)
MAFGGeneProductENSG00000197063 (Ensembl)
ME1GeneProductENSG00000065833 (Ensembl)
MFGE8GeneProductENSG00000140545 (Ensembl)
MGAMGeneProductENSG00000179087 (Ensembl)
MGST1GeneProductENSG00000008394 (Ensembl)
MGST2GeneProductENSG00000085871 (Ensembl)
MGST3GeneProductENSG00000143198 (Ensembl)
MT1IPGeneProduct644314 (Entrez Gene)
MYCGeneProductENSG00000136997 (Ensembl)
MYOFGeneProductENSG00000138119 (Ensembl)
MetabolismPathwayWP702 (WikiPathways)
Multi-drug resistancePathwayWP2489 (WikiPathways)
NAV3GeneProductENSG00000067798 (Ensembl)
NCOA1GeneProductENSG00000084676 (Ensembl)
NCOA2GeneProductENSG00000140396 (Ensembl)
NCOA3GeneProductENSG00000124151 (Ensembl)
NCOA6GeneProductENSG00000198646 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NQO1GeneProductENSG00000181019 (Ensembl)
NR0B2GeneProductENSG00000131910 (Ensembl)
NR1H3GeneProductENSG00000025434 (Ensembl)
NR1H4GeneProductENSG00000012504 (Ensembl)
NR1I2GeneProductENSG00000144852 (Ensembl)
NR1I3GeneProductENSG00000143257 (Ensembl)
NR3C1GeneProductENSG00000113580 (Ensembl)
NRG1GeneProductENSG00000157168 (Ensembl)
NRIP1GeneProductENSG00000180530 (Ensembl)
Nuclear receptorsPathway
PCK1GeneProductENSG00000124253 (Ensembl)
PDE4BGeneProductENSG00000184588 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDK4GeneProductENSG00000004799 (Ensembl)
PGDGeneProductENSG00000142657 (Ensembl)
PLK2GeneProductENSG00000145632 (Ensembl)
PLTPGeneProductENSG00000100979 (Ensembl)
PMP2GeneProductENSG00000147588 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
POU5F1GeneProductENSG00000204531 (Ensembl)
PPAR alpha ligand
PPARAGeneProductENSG00000186951 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PPP1R14CGeneProductENSG00000198729 (Ensembl)
PPP2R4GeneProductENSG00000119383 (Ensembl) plays a role in translocation of CAR
PRDX1GeneProductENSG00000117450 (Ensembl)
PRDX6GeneProductENSG00000117592 (Ensembl)
PRRG4GeneProductENSG00000135378 (Ensembl)
PSMC5GeneProductENSG00000087191 (Ensembl)
PTGES3GeneProductENSG00000110958 (Ensembl)
PTGR1GeneProductENSG00000106853 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
Phase 1

proteins

PathwayWP702 (WikiPathways)
Phase 2 metabolismPathwayWP702 (WikiPathways)
Phase 2

proteins

PathwayWP702 (WikiPathways)
RGS2GeneProductENSG00000116741 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
S100PGeneProductENSG00000163993 (Ensembl)
SCDGeneProductENSG00000099194 (Ensembl)
SCNN1AGeneProductENSG00000111319 (Ensembl)
SCP2GeneProductENSG00000116171 (Ensembl)
SDPRGeneProductENSG00000168497 (Ensembl)
SEC14L1GeneProductENSG00000129657 (Ensembl)
SERPINA1GeneProductENSG00000197249 (Ensembl)
SERPINB2GeneProductENSG00000197632 (Ensembl)
SERPINB9GeneProductENSG00000170542 (Ensembl)
SERTAD2GeneProductENSG00000179833 (Ensembl)
SLC10A1GeneProductENSG00000100652 (Ensembl) inhibition
SLC19A2GeneProductENSG00000117479 (Ensembl)
SLC26A2GeneProductENSG00000155850 (Ensembl)
SLC27A1GeneProductENSG00000130304 (Ensembl)
SLC27A5GeneProductENSG00000083807 (Ensembl)
SLC2A10GeneProductENSG00000197496 (Ensembl)
SLC2A11GeneProductENSG00000133460 (Ensembl)
SLC2A12GeneProductENSG00000146411 (Ensembl)
SLC2A13GeneProductENSG00000151229 (Ensembl)
SLC2A14GeneProductENSG00000173262 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC2A2GeneProductENSG00000163581 (Ensembl)
SLC2A3GeneProductENSG00000059804 (Ensembl)
SLC2A4GeneProductENSG00000181856 (Ensembl)
SLC2A5GeneProductENSG00000142583 (Ensembl)
SLC2A6GeneProductENSG00000160326 (Ensembl)
SLC2A7GeneProductENSG00000197241 (Ensembl)
SLC2A8GeneProductENSG00000136856 (Ensembl)
SLC2A9GeneProductENSG00000109667 (Ensembl)
SLC39A10GeneProductENSG00000196950 (Ensembl)
SLC39A11GeneProductENSG00000133195 (Ensembl)
SLC39A12GeneProductENSG00000148482 (Ensembl)
SLC39A13GeneProductENSG00000165915 (Ensembl)
SLC39A14GeneProductENSG00000104635 (Ensembl)
SLC39A1GeneProductENSG00000143570 (Ensembl)
SLC39A2GeneProductENSG00000165794 (Ensembl)
SLC39A3GeneProductENSG00000141873 (Ensembl)
SLC39A4GeneProductENSG00000147804 (Ensembl)
SLC39A5GeneProductENSG00000139540 (Ensembl)
SLC39A6GeneProductENSG00000141424 (Ensembl)
SLC39A7GeneProductENSG00000112473 (Ensembl)
SLC39A8GeneProductENSG00000138821 (Ensembl)
SLC39A9GeneProductENSG00000029364 (Ensembl)
SLC5A10GeneProductENSG00000154025 (Ensembl)
SLC5A11GeneProductENSG00000158865 (Ensembl)
SLC5A12GeneProductENSG00000148942 (Ensembl)
SLC5A1GeneProductENSG00000100170 (Ensembl)
SLC5A2GeneProductENSG00000140675 (Ensembl)
SLC5A3GeneProductENSG00000198743 (Ensembl)
SLC5A4GeneProductENSG00000100191 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLC5A6GeneProductENSG00000138074 (Ensembl)
SLC5A7GeneProductENSG00000115665 (Ensembl)
SLC5A8GeneProductENSG00000256870 (Ensembl)
SLC5A9GeneProductENSG00000117834 (Ensembl)
SLC6A11GeneProductENSG00000132164 (Ensembl)
SLC6A13GeneProductENSG00000010379 (Ensembl)
SLC6A14GeneProductENSG00000268104 (Ensembl)
SLC6A15GeneProductENSG00000072041 (Ensembl)
SLC6A16GeneProductENSG00000063127 (Ensembl)
SLC6A17GeneProductENSG00000197106 (Ensembl)
SLC6A18GeneProductENSG00000164363 (Ensembl)
SLC6A19GeneProductENSG00000174358 (Ensembl)
SLC6A1GeneProductENSG00000157103 (Ensembl)
SLC6A20GeneProductENSG00000163817 (Ensembl)
SLC6A2GeneProductENSG00000103546 (Ensembl)
SLC6A3GeneProductENSG00000142319 (Ensembl)
SLC6A4GeneProductENSG00000108576 (Ensembl)
SLC6A5GeneProductENSG00000165970 (Ensembl)
SLC6A6GeneProductENSG00000131389 (Ensembl)
SLC6A7GeneProductENSG00000011083 (Ensembl)
SLC6A8GeneProductENSG00000130821 (Ensembl)
SLC6A9GeneProductENSG00000196517 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)
SLCO1B1GeneProductENSG00000134538 (Ensembl)
SLCO2B1GeneProductENSG00000137491 (Ensembl) inhibition
SMARCA1GeneProductENSG00000102038 (Ensembl)
SMC1AGeneProductENSG00000072501 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SOD3GeneProductENSG00000109610 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SPINK13GeneProductENSG00000214510 (Ensembl)
SPRY1GeneProductENSG00000164056 (Ensembl)
SQSTM1GeneProductENSG00000161011 (Ensembl)
SRC GeneProductENSG00000197122 (Ensembl)
SRC GeneProductENSG00000197122 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
SREBF1GeneProductENSG00000072310 (Ensembl)
SRGNGeneProductENSG00000122862 (Ensembl)
SRPX2GeneProductENSG00000102359 (Ensembl)
SRXN1GeneProductENSG00000271303 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STOMGeneProductENSG00000148175 (Ensembl)
SULT1A1GeneProductENSG00000196502 (Ensembl) during fasting
SULT2A1GeneProductENSG00000105398 (Ensembl)
Signal transductionPathwayWP1909 (WikiPathways)
TGFAGeneProductENSG00000163235 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TGFBR3GeneProductENSG00000069702 (Ensembl)
THBDGeneProductENSG00000178726 (Ensembl)
TNF GeneProductENSG00000232810 (Ensembl)
TNFAIP3GeneProductENSG00000118503 (Ensembl)
TNS4GeneProductENSG00000131746 (Ensembl)
TSC22D3GeneProductENSG00000157514 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNRD1GeneProductENSG00000198431 (Ensembl)
TXNRD3GeneProductENSG00000197763 (Ensembl)
Transcription factorsPathwayWP1822 (WikiPathways)
TransportPathwayWP1936 (WikiPathways)
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A7GeneProductENSG00000244122 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)
UGT2B4GeneProductENSG00000156096 (Ensembl)
UGT2B7GeneProductENSG00000171234 (Ensembl)
Unknown
VDRGeneProductENSG00000111424 (Ensembl)
ZIC2GeneProductENSG00000043355 (Ensembl)
bile acid conjugationPathwayWP1788 (WikiPathways)
fatty acid transportPathwayWP357 (WikiPathways)
lipoprotein metabolismPathwayWP4129 (WikiPathways)
mitochondrial beta-oxidationPathwayWP368 (WikiPathways)
mitochondrial omega-oxidationPathwayWP206 (WikiPathways)
p23GeneProductENSG00000110958 (Ensembl)
peroxisomal beta-oxidationPathwayWP1878 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2882"
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