Humoral immune response to fungal and bacterial pathogens (Drosophila melanogaster)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none PlasmatocyteDap Type PPGThiolester ProteinsLysine type PPGFungal B-1-3-glucansProteolytic cascadeFungal and Bacterial Virulence FactorsHemolymphFat Body CellPGRP-LCupd3DiptericinJNK SignalingRelspzpshGNBP3SPETlMyd88plltubPGRP-SDGNBP1PGRP-SADreddimdFaddJakDomelessStatimdDiap2Tak1Tab2Pird5PkeyStatStatStatStatNucleusDifDorsalcactDifDorsalPcactDifDorsalPRelRelDrosomycinAntimicrobial proteinsName: Humoral immune response to fungal and bacterial pathogensOrganism: Drosophila melanogaster


Description

Pathways regulating Drosophila's humoral response to bacterial and fungal pathogens. Pathogens such as fungal B-1-3-glucans and virulence factors illicit signalling pathways through receptors on body fat cells of Drosophila Melanogaster (Protein Toll, PGRP-LC, and Domeless). The activation of receptors initiates pathways that increase transcription of antimicrobial agents and thioester proteins. This pathway is based on figure 1 from Igboin et al.

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngApproved version
Image:Featured.pngFeatured version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : immune response pathway
 

Bibliography

  1. Igboin CO, Griffen AL, Leys EJ; ''The Drosophila melanogaster host model.''; J Oral Microbiol, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116924
Approved
Featured
view09:44, 16 May 2021EweitzModified title
90080view05:03, 13 October 2016Khanspersoverhaul
90079view23:52, 12 October 2016KhanspersModified title
88668view15:31, 12 August 2016JmeliusOntology Term : 'immune response pathway' added !
88667view15:31, 12 August 2016JmeliusOntology Term : 'PW:0000004' removed !
88666view15:31, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
85929view18:26, 21 June 2016AAR&CoModified description
85823view19:22, 15 June 2016AAR&CoModified description
85822view18:57, 15 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Diap2GeneProductFBgn0015247 (Ensembl)
DifGeneProductFBgn0011274 (Ensembl)
DiptericinProteinP24492 (Uniprot-TrEMBL)
DomelessGeneProductFBgn0043903 (Ensembl)
DorsalProteinC7LA93 (Uniprot-TrEMBL) Dorsal Not Specified
DreddGeneProductFBgn0020381 (Ensembl)
DrosomycinProteinP41964 (Uniprot-TrEMBL)
FaddGeneProductFBgn0038928 (Ensembl)
GNBP1GeneProductFBgn0040323 (Ensembl)
GNBP3GeneProductFBgn0040321 (Ensembl)
JNK SignalingPathway
JakGeneProductFBgn0004864 (Ensembl)
Myd88GeneProductFBgn0033402 (Ensembl)
PGRP-LCGeneProductFBgn0035976 (Ensembl)
PGRP-SAGeneProductFBgn0030310 (Ensembl)
PGRP-SDGeneProductFBgn0035806 (Ensembl)
RelGeneProductFBgn0014018 (Ensembl)
SPEGeneProductFBgn0039102 (Ensembl)
StatGeneProductFBgn0016917 (Ensembl)
Tab2GeneProductFBgn0086358 (Ensembl)
Tak1GeneProductFBgn0026323 (Ensembl)
TlGeneProductFBgn0262473 (Ensembl)
cactGeneProductFBgn0000250 (Ensembl)
imdGeneProductFBgn0013983 (Ensembl)
ird5GeneProductFBgn0024222 (Ensembl)
keyGeneProductFBgn0041205 (Ensembl)
pllGeneProductFBgn0010441 (Ensembl)
pshGeneProductFBgn0030926 (Ensembl)
spzGeneProductFBgn0003495 (Ensembl)
tubGeneProductFBgn0003882 (Ensembl)
upd3GeneProductFBgn0053542 (Ensembl)

Annotated Interactions

No annotated interactions

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