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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Plasmatocyte Dap Type PPG Thiolester Proteins Lysine type PPG Fungal B-1-3-glucans Proteolytic cascade Fungal and Bacterial Virulence Factors Hemolymph Fat Body Cell PGRP-LC upd3 Diptericin JNK Signaling Rel spz psh GNBP3 SPE Tl Myd88 pll tub PGRP-SD GNBP1 PGRP-SA Dredd imd Fadd Jak Domeless Stat imd Diap2 Tak1 Tab2 P ird5 P key Stat Stat Stat Stat Nucleus Dif Dorsal cact Dif Dorsal P cact Dif Dorsal P Rel Rel Drosomycin Antimicrobial proteins Name: Humoral immune response to fungal and bacterial pathogens Organism: Drosophila melanogaster
Description
Pathways regulating Drosophila's humoral response to bacterial and fungal pathogens. Pathogens such as fungal B-1-3-glucans and virulence factors illicit signalling pathways through receptors on body fat cells of Drosophila Melanogaster (Protein Toll, PGRP-LC, and Domeless). The activation of receptors initiates pathways that increase transcription of antimicrobial agents and thioester proteins. This pathway is based on figure 1 from Igboin et al.
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Quality Tags
Open Access This pathway is based on a pathway published in an Open Access journal.
Approved version The current version of this pathway was approved for data analysis by Martina Kutmon .
Featured version The current version of this pathway was tagged to be featured on the front page of WikiPathways by Martina Kutmon .
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Bibliography
Igboin CO, Griffen AL, Leys EJ; ''The Drosophila melanogaster host model.''; J Oral Microbiol, 2012 PubMed Europe PMC Scholia
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