Statin inhibition of cholesterol production (Homo sapiens)
From WikiPathways
Description
Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.
Sources: PharmGKB and Wikipedia
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.Quality Tags
Ontology Terms
Bibliography
- Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia
- Wetterau JR, Lin MC, Jamil H; ''Microsomal triglyceride transfer protein.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ABCA1 | GeneProduct | 19 (Entrez Gene) | |
ABCG5 | GeneProduct | 64240 (Entrez Gene) | |
ABCG8 | GeneProduct | 64241 (Entrez Gene) | |
APOA1 | GeneProduct | 335 (Entrez Gene) | |
APOA2 | GeneProduct | 336 (Entrez Gene) | |
APOA4 | GeneProduct | 337 (Entrez Gene) | |
APOA5 | GeneProduct | 116519 (Entrez Gene) | |
APOB | GeneProduct | 338 (Entrez Gene) | |
APOC1 | GeneProduct | 341 (Entrez Gene) | |
APOC2 | GeneProduct | 344 (Entrez Gene) | |
APOC3 | GeneProduct | 345 (Entrez Gene) | |
APOE | GeneProduct | 348 (Entrez Gene) | |
Acyl-CoA synthetase | Protein | 84532 (Entrez Gene) | |
Acyl-CoA | Metabolite | CHEBI:17984 (ChEBI) | |
CETP | GeneProduct | 1071 (Entrez Gene) | |
CYP7A1 | GeneProduct | 1581 (Entrez Gene) | |
Cholesterol ester | Metabolite | C02530 (KEGG Compound) | |
Cholesterol | Metabolite | 57-88-5 (CAS) | |
Cholic Acid | Metabolite | 81-25-4 (CAS) | |
DAG | Metabolite | C00165 (KEGG Compound) | |
DGAT1 | GeneProduct | 8694 (Entrez Gene) | |
FDFT1 | GeneProduct | 2222 (Entrez Gene) | |
Fatty acid | Metabolite | C00162 (KEGG Compound) | |
HDL | Metabolite | CHEBI:47775 (ChEBI) | |
HMG-CoA | Metabolite | HMDB0001375 (HMDB) | |
HMGCR | GeneProduct | 3156 (Entrez Gene) | |
IDL | Metabolite | CHEBI:132933 (ChEBI) | |
LCAT | GeneProduct | 3931 (Entrez Gene) | |
LDL | Metabolite | CHEBI:47774 (ChEBI) | |
LDLR | GeneProduct | 3949 (Entrez Gene) | |
LIPC | GeneProduct | 3990 (Entrez Gene) | |
LPL | GeneProduct | 4023 (Entrez Gene) | |
LRP1 | GeneProduct | 4035 (Entrez Gene) | |
Lipoproteins | Metabolite | CHEBI:6495 (ChEBI) | |
MIR33A | GeneProduct | ENSG00000207932 (Ensembl) | |
MIR33B | GeneProduct | ENSG00000207839 (Ensembl) | |
MTTP | Protein | 4547 (Entrez Gene) | |
Mevalonate arm in more detail | Pathway | WP4190 (WikiPathways) | |
Mevalonate | Metabolite | CHEBI:25350 (ChEBI) | |
PDIA2 | Protein | 64714 (Entrez Gene) | |
PLTP | GeneProduct | 5360 (Entrez Gene) | |
Phospholipid | Metabolite | C00865 (KEGG Compound) | |
SCARB1 | GeneProduct | 949 (Entrez Gene) | |
SOAT1 | GeneProduct | 6646 (Entrez Gene) | |
SQLE | GeneProduct | 6713 (Entrez Gene) | |
Squalene | Metabolite | HMDB0000256 (HMDB) | |
Statin | Metabolite | CHEBI:35664 (ChEBI) | |
Triglyceride | Metabolite | C00422 (KEGG Compound) | |
VLDL | Metabolite | CHEBI:39027 (ChEBI) |
Annotated Interactions
No annotated interactions