Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells (Homo sapiens)

From WikiPathways

Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none LateendosomeMVBLegendEnhanced tumor growthChemoresistancePromotes EMTInhibited apoptosisESCRT-dependent pathwayProliferationManumycin ARAB27ARRASRRAS2MRASHRASKRASNRASALIXARAFMAPK1BRAFRAF1RRASRRAS2MRASHRASKRASNRASMAPK3ALIXHNRNPH1EarlyendosomeMVBRAB5ARAB5BRAB5CHGSRAB27AESCRT-independent pathwayName: Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cellsOrganism: Homo sapiens


Description

Schematic representation of inhibition of exosome biogenesis and secretion by the antibiotic Manumycin A (MA) in castration-resistant prostate cancer cells (CRPC) cells. The inhibition of Ras/Raf/ERK1/2 pathway by MA leads to transcriptional down-regulation of hnRNP H1. A decrease in hnRNP H1 transcripts leads to inhibition of exosome biogenesis and secretion by suppressing ALIX and RAB27A. Description from Datta et al.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Pathway Ontology : p53 signaling pathway
 

Bibliography

  1. Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, Jones JC, Mondal D, Ferrer M, Abdel-Mageed AB; ''Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.''; Cancer Lett, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138745
Approved
view01:06, 1 May 2025EweitzModified title
138744view00:59, 1 May 2025EweitzFix typo, add identifier for metabolite
134835view12:48, 27 July 2024EweitzOntology Term : 'drug pathway' added !
134834view12:47, 27 July 2024EweitzModified description
134833view12:45, 27 July 2024EweitzRefine legend
134832view12:42, 27 July 2024EweitzOntology Term : 'neoplastic cell' added !
97800
CPTAC
view19:10, 8 June 2018KhanspersOntology Term : 'Ras family mediated signaling pathway' added !
97652view20:43, 31 May 2018KhanspersModified title
97651view20:09, 31 May 2018KhanspersOntology Term : 'prostate cancer' added !
97650view20:08, 31 May 2018KhanspersModified description
97649view20:06, 31 May 2018KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ALIXGeneProductENSG00000170248 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
HGSGeneProductENSG00000185359 (Ensembl)
HNRNPH1GeneProductENSG00000169045 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MRASGeneProductENSG00000158186 (Ensembl)
Manumycin AMetaboliteCHEBI:29623 (ChEBI)
NRASGeneProductENSG00000213281 (Ensembl)
RAB27AGeneProductENSG00000069974 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB5BGeneProductENSG00000111540 (Ensembl)
RAB5CGeneProductENSG00000108774 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RRAS2GeneProductENSG00000133818 (Ensembl)
RRASGeneProductENSG00000126458 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4301"
Personal tools