Neovascularization processes (Homo sapiens)

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1HSCNF-kappaBDe novo arteriogenesisNotch1NFKB1VEGFR3VEGFR2VEGFDLL2FAKEPHB4ProliferationTube formationMigrationApoptosisAngiogenesisIntegrinsNOMMP9mKitLsKitLcKitStalk ECArteriolar specificationVEGF signalingNotch signalingDLL4JAG1ECPericytesTip ECSprouting angiogenesisNOTCH3CXCR4SDF-1VasculogenesisSMCMSCSMCEPCEPHB4Cell recruitmentVessel maturationPDGF-BBRemodeling arteriogenesisANGPT1VEGFRHIF1AShear stressCell differentiationMatrix and collagendepositionTGFB1TGFB2TGFB3SMAD1SMAD2TGFBR1ALK1ALK5TGF-beta signalingEPHB2ERK1ERK2PI3KAKT1JNK2JNK1SMAD5Smad8SMAD3NFKB2RELARELBRELPDGF-betaNotch4VEGFSDF-


Description

Neovascularization (aka new vessel formation) is a crucial process related to wound healing. It supplies oxygen and nutrients to, and carries waste from, damaged tissue. Angiogenesis is a type of neovascularization, being a vital process in growth, development, and wound healing.

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Ontology Terms

 

Bibliography

  1. Murakami M, Simons M; ''Fibroblast growth factor regulation of neovascularization.''; Curr Opin Hematol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135060view12:47, 2 August 2024EweitzEconomize layout
135059view12:45, 2 August 2024EweitzEconomize layout
128749view07:59, 21 February 2024EgonwFixed the datasource of a Ensembl identifier
128748view07:57, 21 February 2024EgonwMade four pathways clickable
127967view14:49, 20 January 2024EweitzIdentify more pathways, refine style
127966view14:47, 20 January 2024EweitzIdentify some pathways
127965view14:44, 20 January 2024EweitzModified description
127964view14:41, 20 January 2024EweitzStandardize names of genes and pathways
127963view14:34, 20 January 2024EweitzModified title
127962view14:19, 20 January 2024EweitzOntology Term : 'pericyte' added !
127961view14:19, 20 January 2024EweitzOntology Term : 'smooth muscle cell' added !
107654view08:33, 25 October 2019DeSlAnnotated last GeneProduct Nodes (if possible), changed some to PW nodes (containing "signalling").
107653view08:21, 25 October 2019DeSlAdded more IDs, split up Notch1/4 in two GeneProducts.
107652view08:14, 25 October 2019DeSlAdded several IDs for bottom right.
107651view07:58, 25 October 2019DeSlChanged some GeneProducts to PW nodes (since these describe processes, not individual genes).
107650view07:55, 25 October 2019DeSlChanged MIM-conversions to arrow (since this PW doesn't include metabolites).
107649view07:52, 25 October 2019DeSlConnected last unconnected line.
107648view07:50, 25 October 2019DeSlUpdated not UTF-8 encoded characters
102451view14:28, 23 December 2018DeSlModified description
102450view14:24, 23 December 2018DeSlAdded general lit. ref
102449view14:20, 23 December 2018DeSlAnnotated left bottom side
102448view14:15, 23 December 2018DeSlAnnotated right bottom side
102447view14:05, 23 December 2018DeSlAnnotated right top side
102446view13:56, 23 December 2018DeSlAnnotated top left corner
102362view20:11, 20 December 2018FehrhartOntology Term : 'cardiovascular system homeostasis pathway' added !
102361view20:09, 20 December 2018FehrhartOntology Term : 'endothelial cell' added !
102360view20:07, 20 December 2018Fehrhartconnected unconnected lines
98401view22:06, 31 August 2018CarlosaxgNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
ALK1 GeneProductENSG00000139567 (Ensembl) aka ACVRL1
ALK5 GeneProductENSG00000106799 (Ensembl) aka TGFBR1
ANGPT1GeneProductENSG00000154188 (Ensembl)
AngiogenesisPathwayWP1993 (WikiPathways)
ApoptosisPathway
Arteriolar specificationPathway
CXCR4GeneProductENSG00000121966 (Ensembl)
Cell differentiationPathway
Cell recruitmentPathway
DLL2GeneProduct
DLL4GeneProductENSG00000128917 (Ensembl)
De novo arteriogenesisPathway
EPHB2GeneProductENSG00000133216 (Ensembl)
EPHB4GeneProductENSG00000196411 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl) AKA MAPK3
ERK2 GeneProductENSG00000100030 (Ensembl) AKA MAPL1
FAKGeneProductIPR036137 (InterPro)
HIF1AGeneProductENSG00000100644 (Ensembl)
IntegrinsGeneProduct
JAG1GeneProductENSG00000101384 (Ensembl)
JNK1GeneProductENSG00000107643 (Ensembl) AKA MAPK8
JNK2GeneProductP45984 (Uniprot-TrEMBL) AKA MAPK9, Source: [https://www.uniprot.org/uniprot/P45984]
MMP9GeneProductENSG00000100985 (Ensembl)
Matrix and

collagen

deposition		Pathway
MigrationPathway
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKB2ProteinQ00653 (Uniprot-TrEMBL)
NOGeneProduct
NOTCH3GeneProductENSG00000074181 (Ensembl)
Notch signalingPathwayWP268 (WikiPathways)
Notch1GeneProductP46531 (Uniprot-TrEMBL)
Notch4GeneProductQ99466 (Uniprot-TrEMBL)
PDGF-BBGeneProductIPR000072 (InterPro) "Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB)." SOucre: [https://en.wikipedia.org/wiki/Platelet-derived_growth_factor]. Annotated with enzyme family identifier.
PDGF-betaGeneProductENSG00000100311 (Ensembl)
PI3KGeneProductIPR000403 (InterPro)
ProliferationPathway
RELAProteinQ04206 (Uniprot-TrEMBL)
RELBProteinQ01201 (Uniprot-TrEMBL)
RELProteinQ04864 (Uniprot-TrEMBL)
Remodeling arteriogenesisPathway
SDF- GeneProductENSG00000107562 (Ensembl)
SDF-1GeneProductENSG00000107562 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD5GeneProductENSG00000113658 (Ensembl)
Shear stressPathway
Smad8GeneProductENSG00000120693 (Ensembl) aka Mothers against decapentaplegic homolog 9 also known as SMAD9, SMAD8, and MADH6
Sprouting angiogenesisPathway
TGF-beta signalingPathwayWP366 (WikiPathways)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
Tube formationPathway
VEGFGeneProductLarge protein family, unclear which specific ID is needed.
VEGF signalingPathwayWP1919 (WikiPathways)
VEGFGeneProductIPR000072 (InterPro)
VEGFR2GeneProductENSG00000128052 (Ensembl) aka KDR
VEGFR3GeneProductENSG00000037280 (Ensembl) aka FLT4
VEGFRGeneProductIPR009135 (Uniprot-TrEMBL)
VasculogenesisPathway
Vessel maturationPathway
cKitGeneProductENSG00000157404 (Ensembl) aka SCFR
mKitLGeneProductENSG00000049130 (Ensembl) "The ligand for the c-Kit receptor, KitL, exists as a membrane-associated (mKitL) and a soluble form (sKitL)." [PMID:30410062]. Annotated with KitL, since no separate IDs could be found.
sKitLGeneProductENSG00000049130 (Ensembl) "The ligand for the c-Kit receptor, KitL, exists as a membrane-associated (mKitL) and a soluble form (sKitL)." [PMID:30410062]. Annotated with KitL, since no separate IDs could be found.

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4331"
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