CCL18 signaling (Homo sapiens)

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ASAP3EZRAcK311AcK253AcK258AcK60AcK263Protein1, 2PTMProliferation and differentiation in Tu686, 6-10Band FaDu cellsLactateproductionin PC3 cellsNegative regulation of hsa-miR-199a-5p leading to the increased expression of FZD4(towards Wnt/beta-catenin signaling) CCL18 Signaling PathwayLigandProliferation,migration, invasion andEMT in HSC6 and CAL27 cellsDirectionalmigration ofMDA-MB-231cellsProliferation, andmetastasis of HSC6oral carcinoma cellsProliferationof HSC6 andCAL27 cellsMyofibroblastdifferentiation ofbreast phyllodestumorsSecretion from monocytes/macrophagesthat support hematopoiesisSwitching ofCD4+CD45RO+CD25-T cells intoCD4+CD25+Foxp3+regulatoryT cellsDissociationInvasion in HEEC,ECA109,KYSE30, KYSE140KYSE510, andTE-1 cellsTumor-associatedmacrophage-inducedmetastasis ofMDA-MB-231 cellsMigration & invasionof SMMC-7721 cellsIn OS-RC-2and ACHNcells Abrogates chemotactic responses induced by their ligandsInvasion and migrationof MGC-803, GES-1 andMKN28 cellsEMT inIshikawacellsMigration andtube formationin HUVECsEMT inMDA-MB-231and MCF-7cellsMigration and invasion of BxPC-3 and PANC-1 cellsEnhancesECM adherenceof MDA-MB-231cellsAdhesion andF-actinpolymerizationMigration ofMDA-MB-231 andSKBR3 cellsPolymerizationof F-actin andCytoskeletonreorganizationin A549 and H1299 cellsMigration and invasion ofPANC-1 and Capan-2 cellsMaintenance of the Warburg effectEndothelial-MesenchymalTransformation (EndMT)in HUVECsInduction ofEMT and stemnessin Tu686 andFaDu cellsEMT in HSC6and CAL33 cellsMigration ofCaOV3 andOVCAR3 cellsMigration andinvasion of5637 bladdercancer cellsProliferation,invasion andiigration ofSkov3 cellsModulation ofCXCR4 activityNuclearGi-alphadependentMotility ofMDA-MB-231cellsEMT and invasionof MDA-MB-231and MCF-7 cellslnc-DENND3-2FZD4Ca++CCR6GSK3BS9PLCG1PPIP2PITPNM3Phsa-miR-199a-5pCCR8VIMCDH5CDH1MAPK33Y204T202CHUKS180S176MAPK1Y187T185HOTAIRSTAT3Y705AKT1T308S473CDH2FN1PRKCZPITPKBPTK2BY402SRCY419PTK2Y397ITGA5ITGB1T788T789ANXA2Y24FN1GPER1VCAM1VCAM1RELAS536RELAS536ZEB2JAK2Y1007Y1008CDH1CDH2VIMFN1EMT in Tu686,6-10B and FaDu cellsMTDHMetastasis andEMT in Tu686,6-10B andFaDu cellsNFKBIAS32VEGFCCDH1MMP2Proliferation and migrationof MG63 and 143Bosteosarcoma cellsFAM74A4lnc-FLNA-1TCRBTTLL3HIPK1-AS1lnc-MACC1-1MTERF4UCA1lnc-SLC35A5-1LINC02245lnc-COL5A1-3ATE1-AS1GOLGA6L17PLINC01881lnc-ASAP2-5TFAP2AATF3STAT1EP300TEAD4EP300LINC00319LINC01357lnc-GOLGA8Q-1MYOSLID-AS1MIAT lnc-U2AF2-2lnc-PYGL-1lnc-RGMA-3LINC00649ATP6VOE2-AS1lnc-FANCM-1VASH1-AS1lnc-SSU72P8-2lnc-ESRRB-1lnc-SLC16A3-3LINC00266-3LINC01089RAD51-AS1LINC02582LINC00467ECI2-DTlnc-ZBTB20-1LINC00629LINC01770lnc-ZFP37-1LINC01361PPM1K-DTlnc-SCN8A-1PRKAR1B-AS1LINC00974lnc-PMAIP1-9POT1-AS1BCYRN1Collagenproductionin pulmonaryfibroblastsIKBKBARF6GTPIKBKGARF6GTPPMCYASAP3AcK311KAT2BASAP1Y782Adhesion, migrationand invasion of MCF-7 cellsMMP3CDH1SNAI2PTK2BY402KITLGCDH1CXCL8SNAI1CASP8VEGFATIMP1IL6CCR8 Receptor internalizationNRASLIN28Bhsa-miR-98-5phsa-miR-27b-3pIKBKBS177S181CDH1VIMPTK2VIMSNAI1SP1PSMAD2PSMAD3PCOL1A1Migrationand invasionof MDA-MB-231cellsHematopoiesisin myeloidlong-termbone marrowculturesIL15CCL2CCL3TIMP2TGFB1FGF2MAD1L1CREB1FOSMAPK8Y185T183MAPK9T183Y185ELMO1KIF5BMT-CO2CSF2MMP9CXCR4MTORS2448S2481ACTA2ACTA2hsa-miR-21-5pIntegrin clusteringAttenuation of PIP2 binding associated activation of Ezrin by acetylation PRKCAPPRKCAPProduction ofCollagen infibroblastsCOL1A2COL1A2CCR3CCR1CCR2CCR4CCR5 Antagonistic activityRAC1GTPInvasion andmigration ofA549 and H1299 cellsCDH1CDH2POU5F1BMI1Inducesstem cell-likecharacteristicsin HSC6, CAL33 andSCC15 cellsSNAI2SNAI1 Decreased expression of PTEN (inhibitor of AKT activity) regulated by hsa-miR-21-5p PRKCDCDH1MTDHTWIST1CDH1CDH2VIMKIF5BCDH1VIMALDH1CDH1VIMCDH1CD44LIN28ASNAI1SNAI2TWIST1ZEB1ZEB2LIMK1T508CFL1S3Cytoskeletonreorganizationin MDA-MB-231cellsPMCYPMCYEZRAcK258AcK60AcK253AcK263ARF6 richmembraneprotrusionsDissociationand increasedARF6 activityPMCYPMCYASAP1Y782 Activation of LFA-1 in polarised Th2-cellsITGALITGB2PMCYRelease of intracellular TGFB1IL10Secretion in memory CD4+ T cells CYNU Dissociation and activation of NF-kappaBCYNUPIK3R3Y199PIK3R1Y467PTENhsa-miR-92bhsa-miR-26bhsa-miR-877hsa-miR-27ahsa-miR-106ahsa-miR-17hsa-miR-20bhsa-let-7ehsa-miR-20ahsa-let-7bhsa-let-7dPost-transcriptional regulation of hsa-miR-98-5p TWIST1CDH1CDH2VIMReleasefromleukocytesF-actinpolymerizationin Th2 cellsVEGFCCDH1MMP2mRNAsLncRNAsFZD4PTENCCL18CCL18CCL18CCL18CCL18CCL18ReceptorMoleculeProtein-protein interactionsProtein-protein dissociationProteinRNASmall molecule / metaboliteProtein 1Protein 2Protein complexProtein 1Protein 2Group of genes or proteinsfrom a study or gene familyAcetylationRNAProteinPost-Translational ModificationProteinPTMProteinPTMPhosphositesAcetylation sitesReported to be CCR8-mediatedReported to be PITPNM3-mediatedLeads to through knownunknown mechanisms(Multiple colored edges todisctinguish the crossing edges)CytoplasmPlasmamembraneNucleusProtein transport acrosscellular compartmentsPMCYNULeads to transcriptional ortranslational regulationFigure LegendInhibition of activityCDC25CSNAI2SNAI1CD44PROM1LDHALDHBLDHALDHBSLC2A1HIF1AMYCARNTHistamine


Description

A multi-cellular molecular signaling and functional network map of C-C Motif Chemokine Ligand 18 (CCL18): A chemokine with immunosuppressive and pro-tumor function

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Ontology Terms

 

Bibliography

  1. Krohn SC, Bonvin P, Proudfoot AE; ''CCL18 exhibits a regulatory role through inhibition of receptor and glycosaminoglycan binding.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Nibbs RJ, Salcedo TW, Campbell JD, Yao XT, Li Y, Nardelli B, Olsen HS, Morris TS, Proudfoot AE, Patel VP, Graham GJ; ''C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap.''; J Immunol, 2000 PubMed Europe PMC Scholia
  3. Lin X, Chen L, Yao Y, Zhao R, Cui X, Chen J, Hou K, Zhang M, Su F, Song E; ''CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis.''; Oncotarget, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129659view00:38, 22 May 2024EweitzModified title
126447view19:29, 30 April 2023AlexanderPicocleaned comments and pathway info
126444view19:20, 30 April 2023AlexanderPicofixed legend
126443view19:18, 30 April 2023AlexanderPicofixed legend
126442view19:04, 30 April 2023AlexanderPicoremoved data-coded color
126249view05:54, 18 April 2023EgonwLicense is CCZero (more specific)
119075view21:19, 14 June 2021EweitzOntology Term : 'signaling pathway' added !
119074view21:18, 14 June 2021EweitzModified title
119015view18:48, 9 June 2021EgonwFixed the data source to NCBI Protein
116661view11:56, 9 May 2021KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA2Rna59 (Entrez Gene)
ACTA2ProteinNP_001604.1 (RefSeq)
AKT1GeneProductNP_005154.2 (RefSeq)
ALDH1Rna102867337 (Entrez Gene)
ANXA2ProteinNP_004030.1 (RefSeq)
ARF6ProteinNP_001654.1 (RefSeq)
ARNTProtein205 (Entrez Gene)
ASAP1ProteinNP_060952.2 (RefSeq)
ASAP3ProteinNP_060177.2 (RefSeq)
ATE1-AS1Rna100130887 (Entrez Gene)
ATF3Rna467 (Entrez Gene)
ATP6VOE2-AS1Rna
BCYRN1Rna618 (Entrez Gene)
BMI1ProteinNP_005171.4 (RefSeq)
CASP8ProteinNP_001219.2 (RefSeq)
CCL18ProteinNP_002979.1 (RefSeq)
CCL2ProteinNP_002973.1 (RefSeq)
CCL3ProteinNP_002974.1 (RefSeq)
CCR1ProteinNP_001286.1 (RefSeq)
CCR2ProteinNP_001116868.1 (RefSeq)
CCR3ProteinNP_001828.1 (RefSeq)
CCR4ProteinNP_005499.1 (RefSeq)
CCR5ProteinNP_000570.1 (RefSeq)
CCR6ProteinNP_004358.2 (RefSeq)
CCR8Protein1237 (Entrez Gene)
CCR8ProteinNP_005192.1 (RefSeq)
CD44Rna960 (Entrez Gene)
CD44Rna960 (RefSeq)
CDC25CProteinNP_001781.2 (RefSeq)
CDH1Rna999 (Entrez Gene)
CDH1RnaNP_004351.1 (RefSeq)
CDH2Rna1000 (Entrez Gene)
CDH2ProteinNP_001783.2 (RefSeq)
CDH5ProteinNP_001786.2 (RefSeq)
CFL1 ProteinNP_005498.1 (RefSeq)
CHUKProteinNP_001269.3 (RefSeq)
COL1A1ProteinNP_000079.2 (RefSeq)
COL1A2Rna1278 (Entrez Gene)
COL1A2ProteinNP_000080.2 (RefSeq)
CREB1ProteinNP_004370.1 (RefSeq)
CSF2Rna1437 (Entrez Gene)
CXCL8ProteinNP_000575.1 (RefSeq)
CXCR4ProteinNP_003458.1 (RefSeq)
Ca++Metabolite271 (PubChem-substance)
ECI2-DTRna100507506 (Entrez Gene)
ELMO1 ProteinNP_055615.8 (RefSeq)
EP300Rna2033 (Entrez Gene)
EP300ProteinNP_001420.2 (RefSeq)
EZRProteinNP_003370.2 (RefSeq)
FAM74A4Rna7412 (Entrez Gene)
FGF2ProteinNP_001997.5 (RefSeq)
FN1Rna2335 (Entrez Gene)
FN1ProteinNP_002017.2 (RefSeq)
FOSProteinNP_005243.1 (RefSeq)
FZD4Rna8322 (Entrez Gene)
FZD4ProteinNP_036325.2 (RefSeq)
GOLGA6L17PRna642402 (Entrez Gene)
GPER1ProteinNP_001496.1 (RefSeq)
GSK3BProteinNP_002084.2 (RefSeq)
HIF1ARna3091 (Entrez Gene)
HIPK1-AS1Rna101928846 (Entrez Gene)
HOTAIRRna100124700 (Entrez Gene)
HistamineMetabolite18295 (ChEBI)
IKBKBProteinNP_001547.1 (RefSeq)
IKBKGProteinNP_003630.1 (RefSeq)
IL10ProteinNP_000563.1 (RefSeq)
IL15ProteinNP_751915.1 (RefSeq)
IL6ProteinNP_000591.1 (RefSeq)
ITGA5ProteinNP_002196.4 (RefSeq)
ITGALProteinNP_002200.2 (RefSeq)
ITGB1ProteinNP_002202.2 (RefSeq)
ITGB2ProteinNP_000202.3 (RefSeq)
ITPKBProteinNP_002212.3 (RefSeq)
JAK2ProteinNP_004963.1 (RefSeq)
KAT2BProteinNP_003875.3 (RefSeq)
KIF5BRna3799 (Entrez Gene)
KIF5BProteinNP_004512.1 (RefSeq)
KITLGProteinNP_000890.1 (RefSeq)
LDHARna3939 (Entrez Gene)
LDHAProteinNP_005557.1 (NCBI Protein)
LDHBRna3945 (RefSeq)
LDHBProteinNP_002291.1 (RefSeq)
LIMK1 ProteinNP_002305.1 (RefSeq)
LIN28AProteinNP_078950.1 (RefSeq)
LIN28BProteinNP_001004317.1 (RefSeq)
LINC00266-3Rna441123 (Entrez Gene)
LINC00319Rna284836 (Entrez Gene)
LINC00467Rna84791 (Entrez Gene)
LINC00629Rna100506757 (Entrez Gene)
LINC00649Rna100506334 (Entrez Gene)
LINC00974Rna147093 (Entrez Gene)
LINC01089Rna338799 (Entrez Gene)
LINC01357Rna105378912 (Entrez Gene)
LINC01361Rna101927498 (Entrez Gene)
LINC01770Rna102724312 (Entrez Gene)
LINC01881Rna728323 (Entrez Gene)
LINC02245Rna400958 (Entrez Gene)
LINC02582Rna100505817 (Entrez Gene)
MAD1L1ProteinNP_003541.2 (RefSeq)
MAPK1ProteinNP_002736.3 (RefSeq)
MAPK3ProteinNP_002737.2 (RefSeq)
MAPK8ProteinNP_620634.1 (RefSeq)
MAPK9ProteinNP_002743.3 (RefSeq)
MIAT Rna440823 (Entrez Gene)
MMP2Protein4313 (Entrez Gene)
MMP2ProteinNP_004521.1 (RefSeq)
MMP3ProteinNP_002413.1 (RefSeq)
MMP9Rna4318 (Entrez Gene)
MT-CO2Rna4513 (Entrez Gene)
MTDHRna92140 (Entrez Gene)
MTDHProteinNP_848927.2 (RefSeq)
MTERF4Rna130916 (Entrez Gene)
MTORProteinNP_004949.1 (RefSeq)
MYCRna4609 (Entrez Gene)
MYOSLID-AS1Rna101927865 (Entrez Gene)
NFKBIAProteinNP_065390.1 (RefSeq)
NRASProteinNP_002515.1 (RefSeq)
PIK3R1ProteinNP_852556.2 (RefSeq)
PIK3R3ProteinNP_003620.3 (RefSeq)
PIP2Metabolite37328 (ChEBI)
PITPNM3ProteinNP_112497.2 (RefSeq)
PLCG1ProteinNP_002651.2 (RefSeq)
POT1-AS1Rna401398 (Entrez Gene)
POU5F1ProteinNP_002692.2 (RefSeq)
PPM1K-DTRna105369192 (Entrez Gene)
PRKAR1B-AS1Rna101926963 (Entrez Gene)
PRKCAProteinNP_002728.2 (RefSeq)
PRKCDProteinNP_006245.2 (RefSeq)
PRKCZProteinNP_002735.3 (RefSeq)
PROM1Rna8842 (RefSeq)
PTENRna5728 (Entrez Gene)
PTENProteinNP_000305.3 (RefSeq)
PTK2Rna4747 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTK2BProteinNP_004094.3 (RefSeq)
PTK2ProteinNP_005598.3 (RefSeq)
RAC1 ProteinNP_002924.1 (RefSeq)
RAD51-AS1Rna100505648 (Entrez Gene)
RELAProteinNP_068810.3 (RefSeq)
SLC2A1Rna6513 (Entrez Gene)
SMAD2ProteinNP_005892.1 (RefSeq)
SMAD3ProteinNP_005893.1 (RefSeq)
SNAI1Rna6615 (Entrez Gene)
SNAI1Rna6615 (RefSeq)
SNAI1ProteinNP_005976.2 (RefSeq)
SNAI2Rna6591 (RefSeq)
SNAI2ProteinNP_003059.1 (RefSeq)
SP1ProteinNP_003100.1 (RefSeq)
SRCProteinNP_005408.1 (RefSeq)
STAT1Rna6772 (Entrez Gene)
STAT3ProteinNP_003141.2 (RefSeq)
TCRBRna7412 (Entrez Gene)
TEAD4Rna7004 (Entrez Gene)
TFAP2ARna7020 (Entrez Gene)
TGFB1Protein4313 (Entrez Gene)
TGFB1ProteinNP_000651.3 (RefSeq)
TIMP1ProteinNP_003245.1 (RefSeq)
TIMP2ProteinNP_003246.1 (RefSeq)
TTLL3Rna7412 (Entrez Gene)
TWIST1Rna7291 (Entrez Gene)
TWIST1ProteinNP_000465.1 (RefSeq)
UCA1Rna652995 (Entrez Gene)
VASH1-AS1Rna100506603 (Entrez Gene)
VCAM1Rna7412 (Entrez Gene)
VCAM1ProteinNP_001069.1 (RefSeq)
VEGFAProteinNP_003367.4 (RefSeq)
VEGFCRna7424 (Entrez Gene)
VEGFCProteinNP_005420.1 (RefSeq)
VIMRna7431 (Entrez Gene)
VIMProteinNP_003371.2 (RefSeq)
ZEB1ProteinNP_110378.3 (RefSeq)
ZEB2Protein9839 (Entrez Gene)
ZEB2ProteinNP_055610.1 (RefSeq)
hsa-let-7bRnaMIMAT0000419 (miRBase mature sequence)
hsa-let-7dRnaMIMAT0000419 (miRBase mature sequence)
hsa-let-7eRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-106aRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-17RnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-199a-5pRna
hsa-miR-20aRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-20bRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-21-5pRna406991 (Entrez Gene)
hsa-miR-26bRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-27aRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-27b-3pRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-877RnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-92bRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-98-5pRnaMIMAT0000096 (miRBase mature sequence)
lnc-ASAP2-5Rnalnc-ASAP2-5 (Other)
lnc-COL5A1-3Rnalnc-COL5A1-3 (Other)
lnc-DENND3-2Rna
lnc-ESRRB-1Rna
lnc-FANCM-1Rna
lnc-FLNA-1Rnalnc-FLNA-1 (Other)
lnc-GOLGA8Q-1Rna
lnc-MACC1-1Rnalnc-MACC1-1 (Other)
lnc-PMAIP1-9Rna
lnc-PYGL-1Rna
lnc-RGMA-3Rna
lnc-SCN8A-1Rna
lnc-SLC16A3-3Rna
lnc-SLC35A5-1Rnalnc-SLC35A5-1 (Other)
lnc-SSU72P8-2Rna
lnc-U2AF2-2Rna
lnc-ZBTB20-1Rna
lnc-ZFP37-1Rna

Annotated Interactions

No annotated interactions

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