CCL18 signaling (Homo sapiens)

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Description

A multi-cellular molecular signaling and functional network map of C-C Motif Chemokine Ligand 18 (CCL18): A chemokine with immunosuppressive and pro-tumor function

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Quality Tags

Ontology Terms

 

Bibliography

  1. Krohn SC, Bonvin P, Proudfoot AE; ''CCL18 exhibits a regulatory role through inhibition of receptor and glycosaminoglycan binding.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Nibbs RJ, Salcedo TW, Campbell JD, Yao XT, Li Y, Nardelli B, Olsen HS, Morris TS, Proudfoot AE, Patel VP, Graham GJ; ''C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap.''; J Immunol, 2000 PubMed Europe PMC Scholia
  3. Lin X, Chen L, Yao Y, Zhao R, Cui X, Chen J, Hou K, Zhang M, Su F, Song E; ''CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis.''; Oncotarget, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140127view12:34, 31 July 2025EgonwCalcium ion with unicode
129659view00:38, 22 May 2024EweitzModified title
126447view19:29, 30 April 2023AlexanderPicocleaned comments and pathway info
126444view19:20, 30 April 2023AlexanderPicofixed legend
126443view19:18, 30 April 2023AlexanderPicofixed legend
126442view19:04, 30 April 2023AlexanderPicoremoved data-coded color
126249view05:54, 18 April 2023EgonwLicense is CCZero (more specific)
119075view21:19, 14 June 2021EweitzOntology Term : 'signaling pathway' added !
119074view21:18, 14 June 2021EweitzModified title
119015view18:48, 9 June 2021EgonwFixed the data source to NCBI Protein
116661view11:56, 9 May 2021KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA2Rna59 (Entrez Gene)
ACTA2ProteinNP_001604.1 (RefSeq)
AKT1GeneProductNP_005154.2 (RefSeq)
ALDH1Rna102867337 (Entrez Gene)
ANXA2ProteinNP_004030.1 (RefSeq)
ARF6ProteinNP_001654.1 (RefSeq)
ARNTProtein205 (Entrez Gene)
ASAP1ProteinNP_060952.2 (RefSeq)
ASAP3ProteinNP_060177.2 (RefSeq)
ATE1-AS1Rna100130887 (Entrez Gene)
ATF3Rna467 (Entrez Gene)
ATP6VOE2-AS1Rna
BCYRN1Rna618 (Entrez Gene)
BMI1ProteinNP_005171.4 (RefSeq)
CASP8ProteinNP_001219.2 (RefSeq)
CCL18ProteinNP_002979.1 (RefSeq)
CCL2ProteinNP_002973.1 (RefSeq)
CCL3ProteinNP_002974.1 (RefSeq)
CCR1ProteinNP_001286.1 (RefSeq)
CCR2ProteinNP_001116868.1 (RefSeq)
CCR3ProteinNP_001828.1 (RefSeq)
CCR4ProteinNP_005499.1 (RefSeq)
CCR5ProteinNP_000570.1 (RefSeq)
CCR6ProteinNP_004358.2 (RefSeq)
CCR8Protein1237 (Entrez Gene)
CCR8ProteinNP_005192.1 (RefSeq)
CD44Rna960 (Entrez Gene)
CD44Rna960 (RefSeq)
CDC25CProteinNP_001781.2 (RefSeq)
CDH1Rna999 (Entrez Gene)
CDH1RnaNP_004351.1 (RefSeq)
CDH2Rna1000 (Entrez Gene)
CDH2ProteinNP_001783.2 (RefSeq)
CDH5ProteinNP_001786.2 (RefSeq)
CFL1 ProteinNP_005498.1 (RefSeq)
CHUKProteinNP_001269.3 (RefSeq)
COL1A1ProteinNP_000079.2 (RefSeq)
COL1A2Rna1278 (Entrez Gene)
COL1A2ProteinNP_000080.2 (RefSeq)
CREB1ProteinNP_004370.1 (RefSeq)
CSF2Rna1437 (Entrez Gene)
CXCL8ProteinNP_000575.1 (RefSeq)
CXCR4ProteinNP_003458.1 (RefSeq)
Ca²⁺Metabolite271 (PubChem-substance)
ECI2-DTRna100507506 (Entrez Gene)
ELMO1 ProteinNP_055615.8 (RefSeq)
EP300Rna2033 (Entrez Gene)
EP300ProteinNP_001420.2 (RefSeq)
EZRProteinNP_003370.2 (RefSeq)
FAM74A4Rna7412 (Entrez Gene)
FGF2ProteinNP_001997.5 (RefSeq)
FN1Rna2335 (Entrez Gene)
FN1ProteinNP_002017.2 (RefSeq)
FOSProteinNP_005243.1 (RefSeq)
FZD4Rna8322 (Entrez Gene)
FZD4ProteinNP_036325.2 (RefSeq)
GOLGA6L17PRna642402 (Entrez Gene)
GPER1ProteinNP_001496.1 (RefSeq)
GSK3BProteinNP_002084.2 (RefSeq)
HIF1ARna3091 (Entrez Gene)
HIPK1-AS1Rna101928846 (Entrez Gene)
HOTAIRRna100124700 (Entrez Gene)
HistamineMetabolite18295 (ChEBI)
IKBKBProteinNP_001547.1 (RefSeq)
IKBKGProteinNP_003630.1 (RefSeq)
IL10ProteinNP_000563.1 (RefSeq)
IL15ProteinNP_751915.1 (RefSeq)
IL6ProteinNP_000591.1 (RefSeq)
ITGA5ProteinNP_002196.4 (RefSeq)
ITGALProteinNP_002200.2 (RefSeq)
ITGB1ProteinNP_002202.2 (RefSeq)
ITGB2ProteinNP_000202.3 (RefSeq)
ITPKBProteinNP_002212.3 (RefSeq)
JAK2ProteinNP_004963.1 (RefSeq)
KAT2BProteinNP_003875.3 (RefSeq)
KIF5BRna3799 (Entrez Gene)
KIF5BProteinNP_004512.1 (RefSeq)
KITLGProteinNP_000890.1 (RefSeq)
LDHARna3939 (Entrez Gene)
LDHAProteinNP_005557.1 (NCBI Protein)
LDHBRna3945 (RefSeq)
LDHBProteinNP_002291.1 (RefSeq)
LIMK1 ProteinNP_002305.1 (RefSeq)
LIN28AProteinNP_078950.1 (RefSeq)
LIN28BProteinNP_001004317.1 (RefSeq)
LINC00266-3Rna441123 (Entrez Gene)
LINC00319Rna284836 (Entrez Gene)
LINC00467Rna84791 (Entrez Gene)
LINC00629Rna100506757 (Entrez Gene)
LINC00649Rna100506334 (Entrez Gene)
LINC00974Rna147093 (Entrez Gene)
LINC01089Rna338799 (Entrez Gene)
LINC01357Rna105378912 (Entrez Gene)
LINC01361Rna101927498 (Entrez Gene)
LINC01770Rna102724312 (Entrez Gene)
LINC01881Rna728323 (Entrez Gene)
LINC02245Rna400958 (Entrez Gene)
LINC02582Rna100505817 (Entrez Gene)
MAD1L1ProteinNP_003541.2 (RefSeq)
MAPK1ProteinNP_002736.3 (RefSeq)
MAPK3ProteinNP_002737.2 (RefSeq)
MAPK8ProteinNP_620634.1 (RefSeq)
MAPK9ProteinNP_002743.3 (RefSeq)
MIAT Rna440823 (Entrez Gene)
MMP2Protein4313 (Entrez Gene)
MMP2ProteinNP_004521.1 (RefSeq)
MMP3ProteinNP_002413.1 (RefSeq)
MMP9Rna4318 (Entrez Gene)
MT-CO2Rna4513 (Entrez Gene)
MTDHRna92140 (Entrez Gene)
MTDHProteinNP_848927.2 (RefSeq)
MTERF4Rna130916 (Entrez Gene)
MTORProteinNP_004949.1 (RefSeq)
MYCRna4609 (Entrez Gene)
MYOSLID-AS1Rna101927865 (Entrez Gene)
NFKBIAProteinNP_065390.1 (RefSeq)
NRASProteinNP_002515.1 (RefSeq)
PIK3R1ProteinNP_852556.2 (RefSeq)
PIK3R3ProteinNP_003620.3 (RefSeq)
PIP2Metabolite37328 (ChEBI)
PITPNM3ProteinNP_112497.2 (RefSeq)
PLCG1ProteinNP_002651.2 (RefSeq)
POT1-AS1Rna401398 (Entrez Gene)
POU5F1ProteinNP_002692.2 (RefSeq)
PPM1K-DTRna105369192 (Entrez Gene)
PRKAR1B-AS1Rna101926963 (Entrez Gene)
PRKCAProteinNP_002728.2 (RefSeq)
PRKCDProteinNP_006245.2 (RefSeq)
PRKCZProteinNP_002735.3 (RefSeq)
PROM1Rna8842 (RefSeq)
PTENRna5728 (Entrez Gene)
PTENProteinNP_000305.3 (RefSeq)
PTK2Rna4747 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTK2BProteinNP_004094.3 (RefSeq)
PTK2ProteinNP_005598.3 (RefSeq)
RAC1 ProteinNP_002924.1 (RefSeq)
RAD51-AS1Rna100505648 (Entrez Gene)
RELAProteinNP_068810.3 (RefSeq)
SLC2A1Rna6513 (Entrez Gene)
SMAD2ProteinNP_005892.1 (RefSeq)
SMAD3ProteinNP_005893.1 (RefSeq)
SNAI1Rna6615 (Entrez Gene)
SNAI1Rna6615 (RefSeq)
SNAI1ProteinNP_005976.2 (RefSeq)
SNAI2Rna6591 (RefSeq)
SNAI2ProteinNP_003059.1 (RefSeq)
SP1ProteinNP_003100.1 (RefSeq)
SRCProteinNP_005408.1 (RefSeq)
STAT1Rna6772 (Entrez Gene)
STAT3ProteinNP_003141.2 (RefSeq)
TCRBRna7412 (Entrez Gene)
TEAD4Rna7004 (Entrez Gene)
TFAP2ARna7020 (Entrez Gene)
TGFB1Protein4313 (Entrez Gene)
TGFB1ProteinNP_000651.3 (RefSeq)
TIMP1ProteinNP_003245.1 (RefSeq)
TIMP2ProteinNP_003246.1 (RefSeq)
TTLL3Rna7412 (Entrez Gene)
TWIST1Rna7291 (Entrez Gene)
TWIST1ProteinNP_000465.1 (RefSeq)
UCA1Rna652995 (Entrez Gene)
VASH1-AS1Rna100506603 (Entrez Gene)
VCAM1Rna7412 (Entrez Gene)
VCAM1ProteinNP_001069.1 (RefSeq)
VEGFAProteinNP_003367.4 (RefSeq)
VEGFCRna7424 (Entrez Gene)
VEGFCProteinNP_005420.1 (RefSeq)
VIMRna7431 (Entrez Gene)
VIMProteinNP_003371.2 (RefSeq)
ZEB1ProteinNP_110378.3 (RefSeq)
ZEB2Protein9839 (Entrez Gene)
ZEB2ProteinNP_055610.1 (RefSeq)
hsa-let-7bRnaMIMAT0000419 (miRBase mature sequence)
hsa-let-7dRnaMIMAT0000419 (miRBase mature sequence)
hsa-let-7eRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-106aRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-17RnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-199a-5pRna
hsa-miR-20aRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-20bRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-21-5pRna406991 (Entrez Gene)
hsa-miR-26bRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-27aRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-27b-3pRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-877RnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-92bRnaMIMAT0000419 (miRBase mature sequence)
hsa-miR-98-5pRnaMIMAT0000096 (miRBase mature sequence)
lnc-ASAP2-5Rnalnc-ASAP2-5 (Other)
lnc-COL5A1-3Rnalnc-COL5A1-3 (Other)
lnc-DENND3-2Rna
lnc-ESRRB-1Rna
lnc-FANCM-1Rna
lnc-FLNA-1Rnalnc-FLNA-1 (Other)
lnc-GOLGA8Q-1Rna
lnc-MACC1-1Rnalnc-MACC1-1 (Other)
lnc-PMAIP1-9Rna
lnc-PYGL-1Rna
lnc-RGMA-3Rna
lnc-SCN8A-1Rna
lnc-SLC16A3-3Rna
lnc-SLC35A5-1Rnalnc-SLC35A5-1 (Other)
lnc-SSU72P8-2Rna
lnc-U2AF2-2Rna
lnc-ZBTB20-1Rna
lnc-ZFP37-1Rna

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5097"