Apoptosis modulation by HSP70 (Bos taurus)

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1-8MitochondrionDegradation of proteinsSTRESSProteasomeApoptosomeCELL SURVIVALDegradation ofIk alpha(activation of NFkB)CASP8RIPK1NF-kB PathwayNFKB1MAPK10CASP2HSPA1AApoptosisFADDFASLGAPAF1HSPA1ACASP3BID2HSPA1ACASP8AIFM1CYCSCASP7CASP6TNFRSF1ACYCSCASP9FASMAP3K1FADDTNF-alpha


Description

This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP384(67054) with a 84.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C; ''Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.''; Oncogene, 2003 PubMed Europe PMC Scholia
  2. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG; ''The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES; ''Negative regulation of the Apaf-1 apoptosome by Hsp70.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  4. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G; ''HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
  5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY; ''Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.''; FEBS Lett, 1998 PubMed Europe PMC Scholia
  6. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B; ''The chaperone function of hsp70 is required for protection against stress-induced apoptosis.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  7. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M; ''Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.''; EMBO J, 1998 PubMed Europe PMC Scholia
  8. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G; ''Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.''; FASEB J, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
122662view05:35, 28 April 2022EgonwMade a pathway clickable
117073view14:30, 16 May 2021EweitzModified title
98546view20:52, 14 September 2018KhanspersModified description
98539view20:49, 14 September 2018Khanspersremoved GenMAPP comments
98538view20:49, 14 September 2018KhanspersModified description
98537view20:49, 14 September 2018KhanspersModified description
80857view15:28, 30 June 2015Mkutmonhomology conversion
72060view17:22, 24 October 2013Mkutmonupdated annotation for APAF1
72024view12:47, 24 October 2013Mkutmonfixed unconnected lines
67052view10:00, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
63306view20:54, 9 May 2013MaintBotUpdated to 2013 gpml schema
62054view08:38, 24 April 2013Andra
40607view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
33844view00:33, 9 December 2009MaintBotAutomatic update of empty xrefs
32532view13:00, 17 August 2009MaintBotFixed text labels
32219view12:45, 15 August 2009MaintBotFixed text labels
31715view11:53, 14 August 2009MaintBotFixed group labels
31230view19:44, 13 August 2009MaintBotFixed text labels
30651view22:33, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AIFM1GeneProductENSBTAG00000006838 (Ensembl)
  • Apoptosis Inducing Factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9131
APAF1GeneProductENSBTAG00000021661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:317
ApoptosisPathwayWP254 (WikiPathways)
BID2GeneProductENSBTAG00000013988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:637
CASP2GeneProductENSBTAG00000018159 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:835
CASP3GeneProductENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836
CASP6GeneProductENSBTAG00000012537 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:839
CASP7GeneProductENSBTAG00000006615 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:840
CASP8GeneProductENSBTAG00000015718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841
CASP9GeneProductENSBTAG00000002472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:842
CYCSGeneProductENSBTAG00000022613 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54205
FADDGeneProductENSBTAG00000018274 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8772
FASGeneProductENSBTAG00000010785 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:355
FASLGGeneProductENSBTAG00000032808 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117560
HSPA1AGeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000025441;En:ENSBTAG00000025441;
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
MAPK10GeneProductENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
NF-kB PathwayPathway
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
RIPK1GeneProductENSBTAG00000006378 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8737
TNF-alphaGeneProduct
TNFRSF1AGeneProductENSBTAG00000004211 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7132

Annotated Interactions

No annotated interactions
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