TYSND1 cleaves peroxisomal proteins (Homo sapiens)

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Bibliography

1. Mizuno Y, Ninomiya Y, Nakachi Y, Iseki M, Iwasa H, Akita M, Tsukui T, Shimozawa N, Ito C, Toshimori K, Nishimukai M, Hara H, Maeba R, Okazaki T, Alodaib AN, Al Amoudi M, Jacob M, Alkuraya FS, Horai Y, Watanabe M, Motegi H, Wakana S, Noda T, Kurochkin IV, Mizuno Y, Schönbach C, Okazaki Y.; ''Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility.''; PubMed Europe PMC Scholia
2. Jiang LL, Miyazawa S, Souri M, Hashimoto T.; ''Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.''; PubMed Europe PMC Scholia
3. Schuhmann H, Huesgen PF, Gietl C, Adamska I.; ''The DEG15 serine protease cleaves peroxisomal targeting signal 2-containing proteins in Arabidopsis.''; PubMed Europe PMC Scholia
4. Okumoto K, Kametani Y, Fujiki Y.; ''Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.''; PubMed Europe PMC Scholia
5. Huyghe S, Mannaerts GP, Baes M, Van Veldhoven PP.; ''Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model.''; PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
ACAA1(1-26)	Protein	P09110 (Uniprot-TrEMBL)
ACAA1(1-424)	Protein	P09110 (Uniprot-TrEMBL)
ACAA1	Protein	P09110 (Uniprot-TrEMBL)
ACOX1(1-438)	Protein	Q15067 (Uniprot-TrEMBL)
ACOX1(439-660)	Protein	Q15067 (Uniprot-TrEMBL)
ACOX1	Protein	Q15067 (Uniprot-TrEMBL)
AGPS(1-58)	Protein	O00116 (Uniprot-TrEMBL)
AGPS(1-658)	Protein	O00116 (Uniprot-TrEMBL)
AGPS	Protein	O00116 (Uniprot-TrEMBL)
H2O	Metabolite	CHEBI:15377 (ChEBI)
HSD17B4(1-311)	Protein	P51659 (Uniprot-TrEMBL)
HSD17B4(1-736)	Protein	P51659 (Uniprot-TrEMBL)
HSD17B4(312-736)	Protein	P51659 (Uniprot-TrEMBL)
PHYH(1-30)	Protein	O14832 (Uniprot-TrEMBL)
PHYH(1-338)	Protein	O14832 (Uniprot-TrEMBL)
PHYH	Protein	O14832 (Uniprot-TrEMBL)
SCP2(1-424)	Protein	P22307 (Uniprot-TrEMBL)
SCP2(425-547)	Protein	P22307 (Uniprot-TrEMBL)
SCP2	Protein	P22307 (Uniprot-TrEMBL)
TYSND1(1-110)	Protein	Q2T9J0 (Uniprot-TrEMBL)
TYSND1(111-566)	Protein	Q2T9J0 (Uniprot-TrEMBL)
TYSND1	Protein	Q2T9J0 (Uniprot-TrEMBL)

Annotated Interactions

Source	Target	Type	Database reference	Comment
	ACAA1(1-26)	Arrow	R-HSA-9033529 (Reactome)
ACAA1(1-424)			R-HSA-9033529 (Reactome)
	ACAA1	Arrow	R-HSA-9033529 (Reactome)
	ACOX1(1-438)	Arrow	R-HSA-9033515 (Reactome)
	ACOX1(439-660)	Arrow	R-HSA-9033515 (Reactome)
ACOX1			R-HSA-9033515 (Reactome)
	AGPS(1-58)	Arrow	R-HSA-9033506 (Reactome)
AGPS(1-658)			R-HSA-9033506 (Reactome)
	AGPS	Arrow	R-HSA-9033506 (Reactome)
H2O			R-HSA-9033490 (Reactome)
H2O			R-HSA-9033506 (Reactome)
H2O			R-HSA-9033515 (Reactome)
H2O			R-HSA-9033520 (Reactome)
H2O			R-HSA-9033524 (Reactome)
H2O			R-HSA-9033529 (Reactome)
H2O			R-HSA-9033530 (Reactome)
	HSD17B4(1-311)	Arrow	R-HSA-9033530 (Reactome)
HSD17B4(1-736)			R-HSA-9033530 (Reactome)
	HSD17B4(312-736)	Arrow	R-HSA-9033530 (Reactome)
	PHYH(1-30)	Arrow	R-HSA-9033490 (Reactome)
PHYH(1-338)			R-HSA-9033490 (Reactome)
	PHYH	Arrow	R-HSA-9033490 (Reactome)
			R-HSA-9033490 (Reactome)	The trypsin-like serine-type endopeptidase TYSND1 cleaves PHYH between amino acid residues 30 and 31, yielding PHYH(1-30) and PHYH(31-338). In mice, knockout of Tysnd1 causes reduced localization of Phyh to peroxisomes.
			R-HSA-9033506 (Reactome)	The trypsin-like serine-type endopeptidase TYSND1 cleaves AGPS between amino acid residues 58 and 59, yielding AGPS(1-58) and AGPS(59-658) (inferred from mouse homologs). In mice, knockout of TYSND1 causes reduced localization of AGPS to the peroxisome.
			R-HSA-9033515 (Reactome)	The trypsin-like serine-type endopeptidase TYSND1 cleaves ACOX1 between amino acid residues 438 and 439, yielding ACOX1(1-438) and ACOX1(439-660) (Okumoto et al. 2011, also inferred from mouse and rat homologs).
			R-HSA-9033520 (Reactome)	The trypsin-like serine-type endopeptidase TYSND1 cleaves TYSND1 between amino acid residues 110 and 111, yielding TYSND1(1-110) and TYSND1(111-566) (Okumoto et al. 2011). Self-cleavage of TYSND1 reduces its proteolytic activity.
			R-HSA-9033524 (Reactome)	The trypsin-like serine-type endopeptidase TYSND1 cleaves SCP2 (also known as SCPX) between amino acid residues 424 and 425, yielding SCP2(1-424) and SCP2(425-547) (Okumoto et al. 2011, also inferred from mouse homologs).
			R-HSA-9033529 (Reactome)	The trypsin-like serine-type endopeptidase TYSND1 cleaves ACAA1 between amino acid residues 26 and 27, yielding ACAA1(1-26) and ACAA1(27-424) (Okumoto et al. 2011). In mice, knockout of Tysnd1 causes reduced localization of Acaa1 to the peroxisome.
			R-HSA-9033530 (Reactome)	The trypsin-like serine-type endopeptidase TYSND1 cleaves HSD17B4 (Peroxisomal multifunctional enzyme type 2, MFP-2) between amino acid residues 311 and 312, yielding HSD17B4(1-311) and HSD17B4(312-736) (Okumoto et al. 2011, also inferred from mouse homologs). HSD17B4(1-311) dehydrogenates 3-hydroxyacyl-CoA; HSD17B4(312-736) acts as an enoyl-CoA hydratase (Jiang et al. 1997, reviewed in Huyghe et al. 2006). (In vitro, HSD17B4(312-736) facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes.) The uncleaved protein (HSD17B4) also catalyzes these reactions.
	SCP2(1-424)	Arrow	R-HSA-9033524 (Reactome)
	SCP2(425-547)	Arrow	R-HSA-9033524 (Reactome)
SCP2			R-HSA-9033524 (Reactome)
	TYSND1(1-110)	Arrow	R-HSA-9033520 (Reactome)
	TYSND1(111-566)	Arrow	R-HSA-9033520 (Reactome)
TYSND1			R-HSA-9033520 (Reactome)
TYSND1		mim-catalysis	R-HSA-9033490 (Reactome)
TYSND1		mim-catalysis	R-HSA-9033506 (Reactome)
TYSND1		mim-catalysis	R-HSA-9033515 (Reactome)
TYSND1		mim-catalysis	R-HSA-9033520 (Reactome)
TYSND1		mim-catalysis	R-HSA-9033524 (Reactome)
TYSND1		mim-catalysis	R-HSA-9033529 (Reactome)
TYSND1		mim-catalysis	R-HSA-9033530 (Reactome)