Ophthalmate biosynthesis in hepatocytes (Homo sapiens)
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Description
This pathway visualises the mechanism of ophthalmate biosynthesis in hepatocytes. GSH can inhibits GCC; however when the cell is facing oxidative stress, GSH is consumed, and therefore activating GCS. This enhances the biosynthesis of ophthalmate, which is transported out of the cell over the hepatocellular membrane via MRP transporters.
Quality Tags
Ontology Terms
Saving...Bibliography
- Orlowski M, Wilk S; ''Synthesis of ophthalmic acid in liver and kidney in vivo.''; Biochem J, 1978 PubMed Europe PMC Scholia
- Soga T, Baran R, Suematsu M, Ueno Y, Ikeda S, Sakurakawa T, Kakazu Y, Ishikawa T, Robert M, Nishioka T, Tomita M; ''Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
- Oppenheimer L, Wellner VP, Griffith OW, Meister A; ''Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites.''; J Biol Chem, 1979 PubMed Europe PMC Scholia
- Huang CS, Moore WR, Meister A; ''On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.''; Proc Natl Acad Sci U S A, 1988 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2AB | Metabolite | Q27104317 (Wikidata)  | aka 2-aminobutyrate |
| Cys | Metabolite | Q186474 (Wikidata) | |
| GCS | Protein | 6.3.2.2 (Enzyme Nomenclature) | aka Glutamate Cysteine Ligase (GCL) (EC 6.3.2.2), previously known as gamma-glutamylcysteine synthetase (GCS) |
| GS | Protein | 6.3.2.3 (Enzyme Nomenclature) | aka Glutathione synthetase (GSS) |
| GSH | Metabolite | Q116907 (Wikidata) | aka glutathione |
| Gamma-Glu-2AB | Metabolite | 78437958 (PubChem-compound) | aka gamma-Glutamyl-2-aminobutyrate |
| Gamma-Glu-Cys | Metabolite | Q288236 (Wikidata) | |
| MRP-transporter | Protein | ||
| Ophthalmate | Metabolite | Q7098084 (TTD Drug) | aka ophthalmic acid |
| Ophthalmate | Metabolite | Q7098084 (Wikidata) | aka ophthalmic acid |
Annotated Interactions
No annotated interactions
