FOXA2 pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none IRS2IRS1Apolipoprotein B-100PPARGC1BSLC27A5FOXO1InsulinTAGsMTTPChREBPSREBP-1cABCC2SLCO1B1ABCC4ABCC3FOXA2FOXA1GSTA1GSTA2GSTM2FASNAcetyl-CoA carboxylase 1FOXA2InsulinName: FOXA2 pathwayOrganism: Homo sapiens


Description

Role of Foxa2

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : heme biosynthetic pathway
 

Bibliography

  1. Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, Smirnova O, Matschinsky FM, Kaestner KH; ''Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.''; Mol Endocrinol, 2010 PubMed Europe PMC Scholia
  2. Horton JD; ''Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis.''; Biochem Soc Trans, 2002 PubMed Europe PMC Scholia
  3. Wolfrum C, Besser D, Luca E, Stoffel M; ''Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  4. Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH; ''Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.''; Nat Med, 2008 PubMed Europe PMC Scholia
  5. Wolfrum C, Stoffel M; ''Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion.''; Cell Metab, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116631
Approved
view11:19, 9 May 2021EweitzModified title
116279view04:52, 26 April 2021KhanspersOntology Term : 'regulatory pathway' added !
115703view08:08, 8 March 2021Fehrhartconnected unconnected line
115683view18:20, 3 March 2021EgonwNot a conversion
115625view11:45, 2 March 2021ChesdeWindtModified title
115620view00:23, 2 March 2021ChesdeWindtNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
Acetyl-CoA carboxylase 1ProteinQ13085 (Uniprot-TrEMBL)
Apolipoprotein B-100ProteinP04114 (Uniprot-TrEMBL)
ChREBPProteinQ9NP71 (Uniprot-TrEMBL)
FASNGeneProductENSG00000169710 (Ensembl)
FOXA1GeneProductENSG00000129514 (Ensembl)
FOXA2 GeneProductENSG00000125798 (Ensembl)
FOXA2GeneProductENSG00000125798 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
GSTA1GeneProductENSG00000243955 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
GSTM2GeneProductENSG00000213366 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
InsulinProteinA6XGL2 (Uniprot-TrEMBL)
MTTPGeneProductENSG00000138823 (Ensembl)
PPARGC1BGeneProductENSG00000155846 (Ensembl)
SLC27A5GeneProductENSG00000083807 (Ensembl)
SLCO1B1GeneProductENSG00000134538 (Ensembl)
SREBP-1cProteinP36956 (Uniprot-TrEMBL)
TAGsMetabolite17855 (ChEBI)

Annotated Interactions

No annotated interactions

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