Lipid metabolism in senescent cells (Homo sapiens)

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1Subset PLA2 isozymesPlasma membraneSASPSenescence-associated secretory phenotypePLA2G3HRASALOX5OxylipinSLCO2A1Cell cyclearrestPLA2Lipid dropletsCDKN1APTGS2PUFATP53Free PUFACytosolPTGS2OxylipinbiosynthesisPLA2G2DPLA2G4APLA2G4CPLA2G4DPLA2G4EPLA2G4FPLA2G5PLA2G6PLA2G7PLA2G10PLA2G12APLA2G12BPLA2G1B


Description

Description of the affected lipid metabolism in senecent cells.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Wiley CD, Campisi J; ''The metabolic roots of senescence: mechanisms and opportunities for intervention.''; Nat Metab, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134714view12:29, 26 July 2024EweitzStandardize case, use singular
120374view20:35, 29 November 2021MkutmonOntology Term : 'cellular senescence pathway' added !
120372view20:34, 29 November 2021MkutmonOntology Term : 'lipid metabolic pathway' added !
120371view20:29, 29 November 2021Mkutmonadded subset PLA2 isozymes
120369view20:20, 29 November 2021MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALOX5GeneProductENSG00000012779 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
Cell cycle arrestPathway
Free PUFAMetaboliteCHEBI:26208 (ChEBI)
HRASGeneProductENSG00000174775 (Ensembl)
Lipid dropletsQ573950 (Wikidata)
Oxylipin biosynthesisPathway
OxylipinMetaboliteCHEBI:61121 (ChEBI)
PLA23.1.1.4 (Enzyme Nomenclature)
PLA2G10GeneProductENSG00000069764 (Ensembl)
PLA2G12AGeneProductENSG00000123739 (Ensembl)
PLA2G12BGeneProductENSG00000138308 (Ensembl)
PLA2G1BGeneProductENSG00000170890 (Ensembl)
PLA2G2DGeneProductENSG00000117215 (Ensembl)
PLA2G3GeneProductENSG00000100078 (Ensembl)
PLA2G4AGeneProductENSG00000116711 (Ensembl)
PLA2G4CGeneProductENSG00000105499 (Ensembl)
PLA2G4DGeneProductENSG00000159337 (Ensembl)
PLA2G4EGeneProductENSG00000188089 (Ensembl)
PLA2G4FGeneProductENSG00000168907 (Ensembl)
PLA2G5GeneProductENSG00000127472 (Ensembl)
PLA2G6GeneProductENSG00000184381 (Ensembl)
PLA2G7GeneProductENSG00000146070 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
PUFAMetaboliteCHEBI:26208 (ChEBI)
SLCO2A1GeneProductENSG00000174640 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)

Annotated Interactions

No annotated interactions

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