Uterine natural killer cells and progesterone, estrogen, and chorionic gonadotropin (Homo sapiens)

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Description

Immunometabolism at maternal-fetal interface: interactions between the hormones progesterone (P4), estrogen (estradiol, E2), and human chorionic gonadotropin (hCG) and uterine natural killer cells (uNK). This model represents the secretory phase of the menstrual cycle and first trimester period of pregnancy for these interactions.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Zhang X, Wei H; ''Role of Decidual Natural Killer Cells in Human Pregnancy and Related Pregnancy Complications.''; Front Immunol, 2021 PubMed Europe PMC Scholia
  2. Szekeres-Bartho J, Šućurović S, Mulac-Jeričević B; ''The Role of Extracellular Vesicles and PIBF in Embryo-Maternal Immune-Interactions.''; Front Immunol, 2018 PubMed Europe PMC Scholia
  3. Kitaya K, Yasuda J, Nakayama T, Fushiki S, Honjo H; ''Effect of female sex steroids on human endometrial CD16neg CD56bright natural killer cells.''; Fertil Steril, 2003 PubMed Europe PMC Scholia
  4. Sentman CL, Meadows SK, Wira CR, Eriksson M; ''Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone.''; J Immunol, 2004 PubMed Europe PMC Scholia
  5. Gordon SM; ''Interleukin-15 in Outcomes of Pregnancy.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
  6. Gregori S, Amodio G, Quattrone F, Panina-Bordignon P; ''HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal Niche.''; Front Immunol, 2015 PubMed Europe PMC Scholia
  7. Wang F, Qualls AE, Marques-Fernandez L, Colucci F; ''Biology and pathology of the uterine microenvironment and its natural killer cells.''; Cell Mol Immunol, 2021 PubMed Europe PMC Scholia
  8. Zhou J, Yan P, Ma W, Li J; ''Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders.''; Cytokine Growth Factor Rev, 2025 PubMed Europe PMC Scholia
  9. van den Heuvel MJ, Chantakru S, Xuemei X, Evans SS, Tekpetey F, Mote PA, Clarke CL, Croy BA; ''Trafficking of circulating pro-NK cells to the decidualizing uterus: regulatory mechanisms in the mouse and human.''; Immunol Invest, 2005 PubMed Europe PMC Scholia
  10. Xie M, Li Y, Meng YZ, Xu P, Yang YG, Dong S, He J, Hu Z; ''Uterine Natural Killer Cells: A Rising Star in Human Pregnancy Regulation.''; Front Immunol, 2022 PubMed Europe PMC Scholia
  11. Qu X, Yang M, Zhang W, Liang L, Yang Y, Zhang Y, Deng B, Gao W, Liu J, Yang Q, Kong B, Gong F; ''Osteopontin expression in human decidua is associated with decidual natural killer cells recruitment and regulated by progesterone.''; In Vivo, 2008 PubMed Europe PMC Scholia
  12. Motomura K, Miller D, Galaz J, Liu TN, Romero R, Gomez-Lopez N; ''The effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation.''; J Steroid Biochem Mol Biol, 2023 PubMed Europe PMC Scholia
  13. Wang X, Zhao XY; ''Transcription Factors Associated With IL-15 Cytokine Signaling During NK Cell Development.''; Front Immunol, 2021 PubMed Europe PMC Scholia
  14. Gong H, Chen Y, Xu J, Xie X, Yu D, Yang B, Kuang H; ''The regulation of ovary and conceptus on the uterine natural killer cells during early pregnancy.''; Reprod Biol Endocrinol, 2017 PubMed Europe PMC Scholia
  15. Schumacher A, Zenclussen AC; ''Human Chorionic Gonadotropin-Mediated Immune Responses That Facilitate Embryo Implantation and Placentation.''; Front Immunol, 2019 PubMed Europe PMC Scholia
  16. Guo W, Li P, Zhao G, Fan H, Hu Y, Hou Y; ''Glucocorticoid receptor mediates the effect of progesterone on uterine natural killer cells.''; Am J Reprod Immunol, 2012 PubMed Europe PMC Scholia
  17. Gibson DA, Greaves E, Critchley HO, Saunders PT; ''Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2.''; Hum Reprod, 2015 PubMed Europe PMC Scholia
  18. van den Heuvel M, Peralta C, Bashar S, Taylor S, Horrocks J, Croy BA; ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140168view06:02, 3 August 2025EgonwModified description
140167view06:02, 3 August 2025EgonwModified title
139889view19:37, 9 July 2025EgonwModified title
139880view18:04, 9 July 2025AyoubElHabchiChanged some names
139877view13:08, 9 July 2025AyoubElHabchiAdded a reference at 'recruitment'
139811view18:28, 6 July 2025EweitzOntology Term : 'endothelial cell' added !
139810view18:27, 6 July 2025EweitzOntology Term : 'natural killer cell' added !
139795view15:20, 6 July 2025AyoubElHabchiCorrected some wrong annotations.
139755view09:10, 3 July 2025DeSlUpdated title and description
139754view09:05, 3 July 2025DeSlTrying to resolve empty reference
139748view21:36, 2 July 2025AyoubElHabchiDeleted some random accident objects
139738view14:55, 2 July 2025AyoubElHabchiOntology Term : 'Jak-Stat signaling pathway' added !
139734view20:49, 1 July 2025AyoubElHabchiOntology Term : 'immune response pathway' added !
139733view20:48, 1 July 2025AyoubElHabchiOntology Term : 'immune system disease' added !
139732view20:47, 1 July 2025AyoubElHabchiOntology Term : 'chemokine mediated signaling pathway' added !
139731view20:46, 1 July 2025AyoubElHabchiOntology Term : 'cytokine mediated signaling pathway' added !
139730view20:45, 1 July 2025AyoubElHabchiOntology Term : 'integrin mediated signaling pathway' added !
139729view20:42, 1 July 2025AyoubElHabchiFixed the reference list
139707view22:53, 30 June 2025AyoubElHabchiAdded different sections in the secretory phase (recruitment, migration, proliferation and differentiaton). Also added the biological interactions between hormons and the uNK cell during first trimester period.
139411view08:46, 16 June 2025AyoubElHabchiAdded changes to recruitment of nkcells
139410view07:39, 16 June 2025AyoubElHabchiNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ANGPT1ProteinQ15389 (Uniprot-TrEMBL)
ANGPT2ProteinO15123 (Uniprot-TrEMBL)
BCL2ProteinP10415 (Uniprot-TrEMBL)
CCL2ProteinP13500 (Uniprot-TrEMBL)
CCL3ProteinP10147 (Uniprot-TrEMBL)
CCL4ProteinP13236 (Uniprot-TrEMBL)
CCL5ProteinP13501 (Uniprot-TrEMBL)
CCL7ProteinP80098 (Uniprot-TrEMBL)
CCL8ProteinP80075 (Uniprot-TrEMBL)
CD69ProteinQ07108 (Uniprot-TrEMBL)
CX3CL1ProteinP78423 (Uniprot-TrEMBL)
CXCL10ProteinP02778 (Uniprot-TrEMBL)
CXCL11ProteinO14625 (Uniprot-TrEMBL)
CXCL12ProteinP48061 (Uniprot-TrEMBL)
CXCL8 ProteinP10145 (Uniprot-TrEMBL)
CXCL8ProteinP10145 (Uniprot-TrEMBL)
CXCR3ProteinP49682 (Uniprot-TrEMBL)
CXCR4ProteinP61073 (Uniprot-TrEMBL)
ESR2ProteinQ92731 (Uniprot-TrEMBL)
EstradiolMetaboliteCHEBI:23965 (ChEBI)
EstrogenMetaboliteCHEBI:50114 (ChEBI)
GAB3ProteinQ8WWW8 (Uniprot-TrEMBL)
GATA2ProteinP23769 (Uniprot-TrEMBL)
HLA-GProteinP17693 (Uniprot-TrEMBL)
IFN-γProteinP01579 (Uniprot-TrEMBL)
IL-15ProteinP40933 (Uniprot-TrEMBL)
IL-6ProteinP05231 (Uniprot-TrEMBL)
IL10ProteinP22301 (Uniprot-TrEMBL)
IL15RAProteinQ13261 (Uniprot-TrEMBL)
IL2RBProteinP14784 (Uniprot-TrEMBL)
IL3ProteinP08700 (Uniprot-TrEMBL)
IL4ProteinP05112 (Uniprot-TrEMBL)
JAK1ProteinP23458 (Uniprot-TrEMBL)
JAK3ProteinP52333 (Uniprot-TrEMBL)
KIR2DL4ProteinQ99706 (Uniprot-TrEMBL)
L-selectin ProteinP14151 (Uniprot-TrEMBL)
MADCAM1ProteinQ13477 (Uniprot-TrEMBL)
MAP2K4ProteinP45985 (Uniprot-TrEMBL)
MAPK11ProteinQ15759 (Uniprot-TrEMBL)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MCL1ProteinQ07820 (Uniprot-TrEMBL)
MRC1ProteinP22897 (Uniprot-TrEMBL)
NKp30ProteinO14931 (Uniprot-TrEMBL)
NKp44ProteinO95944 (Uniprot-TrEMBL)
NKp46ProteinO76036 (Uniprot-TrEMBL)
NR3C1ProteinP04150 (Uniprot-TrEMBL) Glucocorticoid receptor
PGRProteinP06401 (Uniprot-TrEMBL)
PIBF1ProteinQ8WXW3 (Uniprot-TrEMBL)
ProgesteroneMetaboliteCHEBI:17026 (ChEBI)
STAT5AProteinP42229 (Uniprot-TrEMBL)
STAT5BProteinP51692 (Uniprot-TrEMBL)
TNFProteinP01375 (Uniprot-TrEMBL)
VCAM1ProteinP19320 (Uniprot-TrEMBL)
VEGFAProteinP15692 (Uniprot-TrEMBL)
hCGMetaboliteQ407172 (Wikidata)
α4-integrinProteinP13612 (Uniprot-TrEMBL)
γcProteinP31785 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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