Wnt signaling pathway and pluripotency (Bos taurus)

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531+pTR: Transcriptional RegulationDifferentiationStabilized beta-cateninUbiquitin Taggedbeta-cateninWnt ReceptorsCytoskeletonPromotes DifferentiationBIOTRTRNucleusTcf/Lef-1IQ1beta-cateninTcf/Lef-1TRPluripotencyTRRecruitment to UnknownUbiquitin Conjugating Enzyme+pPP2AFrizzled LigandsProtein Kinase CTRTRTcf/Lef-1+pPromotes PluripotencyPhosphorylated beta-cateninbeta-catenin24WNT7ACTNND1FOXD3APCPLAUTCF7ESRRBWNT6ZBTB33LEF1DVL2PRKCATP53WNT3FRAT1NFYAGrouchoWNT10BNKD1FZD6FZD4MAPK9WNT1FZD7PPP2R2CLRP5PRKCBCCND2PPP2R2BWNT9BPrkccFZD3PPP2CBPRKCEFOSL1AXIN1DVL1FZD10PRKCDPPM1JNANOGCTBP2TCF7L1WNT2BFZD1PPP2R3BPPP2R2AWNT5BWNT11FZD2PRKCIJUNPPARDFBXW2CCND3PRKCZWNT3ARACGAP1RHOA26S Proteasome DegradationCD44ApoptosisLDLRCSNK1EMYCLOC784935PPP2CACTNNB1WNT5AGSK3BPPP2R1BCCND1NKD2PPP2R1AAXIN2WNT16FZD8CREBBPWNT10APRKD1CTBP1FZD5FZD9PRKCHWNT11PPP2R5CPPP2R3APRKCQNLKWNT7BPPP2R5EMAPK10MMP7MAP3K7POU5F1SOX2LRP6LOC789600DVL3PPP2R4WNT2PAFAH1B1TCF7L2


Description

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.

A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP399(r45007) with a 85% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  2. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  3. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC Scholia
  4. Yi F, Pereira L, Merrill BJ; ''Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.''; Stem Cells, 2008 PubMed Europe PMC Scholia
  5. Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC Scholia
  6. ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html,
  7. Zhang X, Zhang J, Wang T, Esteban MA, Pei D; ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
120483view09:20, 8 December 2021EgonwMade two pathways clickable
117625view11:44, 21 May 2021EweitzModified title
115729view09:29, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
86915view08:05, 14 July 2016MkutmonOntology Term : 'pluripotent stem cell' added !
86914view08:05, 14 July 2016MkutmonOntology Term : 'Wnt signaling pathway' added !
86913view08:05, 14 July 2016MkutmonOntology Term : 'Wnt signaling, canonical pathway' added !
86912view08:04, 14 July 2016Mkutmonfix ontology tag issue
80808view15:26, 30 June 2015Mkutmonhomology conversion
72100view21:41, 24 October 2013Mkutmonadded datasource for "Proteasome Degradation" and "Apoptosis"
63388view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
48128view05:47, 9 May 2012MaintBotUpdating from human to fix xref duplication
40561view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33799view00:16, 9 December 2009MaintBotAutomatic update of empty xrefs
32489view12:45, 17 August 2009MaintBotFixed text labels
32184view12:33, 15 August 2009MaintBotFixed text labels
31655view11:37, 14 August 2009MaintBotFixed group labels
31187view19:29, 13 August 2009MaintBotFixed text labels
30579view22:08, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183
APCGeneProduct533233 (Entrez Gene)
AXIN1GeneProduct504357 (Entrez Gene)
AXIN2GeneProduct511619 (Entrez Gene)
ApoptosisPathwayWP254
CCND1GeneProduct524530 (Entrez Gene)
CCND2GeneProduct615414 (Entrez Gene)
CCND3GeneProduct540547 (Entrez Gene)
CD44GeneProduct281057 (Entrez Gene)
CREBBPGeneProduct505453 (Entrez Gene)
CSNK1EGeneProduct
CTBP1GeneProduct513131 (Entrez Gene)
CTBP2GeneProduct281730 (Entrez Gene)
CTNNB1GeneProduct539003 (Entrez Gene)
CTNND1GeneProduct515187 (Entrez Gene)
DVL1GeneProduct523325 (Entrez Gene)
DVL2GeneProduct614312 (Entrez Gene)
DVL3GeneProduct539203 (Entrez Gene)
ESRRBGeneProduct528437 (Entrez Gene)
FBXW2GeneProduct767863 (Entrez Gene)
FOSL1GeneProduct531389 (Entrez Gene)
FOXD3GeneProduct
FRAT1GeneProduct505664 (Entrez Gene)
FZD10GeneProduct
FZD1GeneProduct445417 (Entrez Gene)
FZD2GeneProduct538507 (Entrez Gene)
FZD3GeneProduct445419 (Entrez Gene)
FZD4GeneProduct445416 (Entrez Gene)
FZD5GeneProduct538536 (Entrez Gene)
FZD6GeneProduct445418 (Entrez Gene)
FZD7GeneProduct524255 (Entrez Gene)
FZD8GeneProduct
FZD9GeneProduct521364 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
GrouchoGeneProduct
JUNGeneProduct280831 (Entrez Gene)
LDLRGeneProduct281276 (Entrez Gene)
LEF1GeneProduct535399 (Entrez Gene)
LOC784935GeneProduct784935 (Entrez Gene)
LOC789600GeneProduct789600 (Entrez Gene)
LRP5GeneProduct534450 (Entrez Gene)
LRP6GeneProduct536328 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MMP7GeneProduct286794 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
NANOGGeneProduct538951 (Entrez Gene)
NFYAGeneProduct
NKD1GeneProduct618586 (Entrez Gene)
NKD2GeneProduct
NLKGeneProduct507204 (Entrez Gene)
PAFAH1B1GeneProduct282513 (Entrez Gene)
PLAUGeneProduct281408 (Entrez Gene)
POU5F1GeneProduct282316 (Entrez Gene)
PPARDGeneProduct353106 (Entrez Gene)
PPM1JGeneProduct
PPP2CAGeneProduct282320 (Entrez Gene)
PPP2CBGeneProduct524361 (Entrez Gene)
PPP2R1AGeneProduct535321 (Entrez Gene)
PPP2R1BGeneProduct100138150 (Entrez Gene)
PPP2R2AGeneProduct508045 (Entrez Gene)
PPP2R2BGeneProduct509290 (Entrez Gene)
PPP2R2CGeneProduct782110 (Entrez Gene)
PPP2R3AGeneProduct787607 (Entrez Gene)
PPP2R3BGeneProduct
PPP2R4GeneProduct514460 (Entrez Gene)
PPP2R5CGeneProduct
PPP2R5EGeneProduct533617 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCEGeneProduct507041 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCIGeneProduct528478 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PRKD1GeneProduct533270 (Entrez Gene)
PrkccGeneProduct
RACGAP1GeneProduct514618 (Entrez Gene)
RHOAGeneProduct338049 (Entrez Gene)
SOX2GeneProduct784383 (Entrez Gene)
TCF7GeneProduct
TCF7L1GeneProduct515303 (Entrez Gene)
TCF7L2GeneProduct
TP53GeneProduct281542 (Entrez Gene)
WNT10AGeneProduct
WNT10BGeneProduct539337 (Entrez Gene)
WNT11GeneProduct613288 (Entrez Gene) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
WNT1GeneProduct540662 (Entrez Gene)
WNT16GeneProduct538627 (Entrez Gene)
WNT2GeneProduct493729 (Entrez Gene)
WNT2BGeneProduct445420 (Entrez Gene)
WNT3GeneProduct540753 (Entrez Gene)
WNT3AGeneProduct522467 (Entrez Gene)
WNT5AGeneProduct530005 (Entrez Gene)
WNT5BGeneProduct508008 (Entrez Gene)
WNT6GeneProduct505075 (Entrez Gene)
WNT7AGeneProduct533782 (Entrez Gene)
WNT7BGeneProduct
WNT9BGeneProduct541243 (Entrez Gene)
ZBTB33GeneProduct784871 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1010"