Folic acid network (Mus musculus)

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1013252228941921, 2661881623, 24121, 27297BInfluence on expressionTBTGeneric enzymeBBNegative effectBReactionBindingIEBNucleotide biosynthesisSynthesis of cholineMain functionsBBBTransformationBFormation of methionineTFormation of HemeCompetitionBBBBBBBBTTBBInterconversionConversionTransportMETABOLITEBTINORGANIC IONBINTRACELULARUnspecified interactionBBTBBTCNTUnspecified effectPositive effectBBPLASMA15-HETESODCopperMethionine2-Ketobutyric acidL-Glutamic acidManganeseGlycineSepw1Gpx6GlycineFads2PGG3MthfrThromboxane B2XdhCobalamin15-HETEFMN1PGG2Pyrodoxal-5'-phosphateLeukotriene D4ALA (n-3)PtgisPGE2SelkPyrodoxal-5'-phosphateDHA (n-3)PnpoF2-IsoprostaneLeukotriene B4PGD2Alox5ZincPGH2Gpx25,10-METHYL-THFNiacin5-HPETEEthanolamineLeukotriene D4NADPHMethionine sulfoxideTryptophanMethylmalonic acid Mtra-tocopherolLipoxin B4CbsPGI2FOLIC ACIDEndoperoxidaseGpx1C22:5 (n-6)FOLIC ACIDAA (n-6)ThioredoxinPGFSLA (n-6)AA (n-6)PGF2aa TocopherolCholineTxnrd2LA (n-6)BTromboxane A2EPA (n-3)PGF2aGsrAscorbic acidVitamin B12Lipoxin A4SeleniumLeukotriene A4Lipoic acidKmod5 desaturase1-MethylnicotinamidePGI2RiboflavinS-Adenosylmethionine PtgdsAdipic acid T1-methylnicotinamideGpx3d4 desaturaseTranscobalaminL-Glutamic acidTRXR 3Vitamin B12Thromboxane A2DHA (n-3)GlutathioneAdipic acidCatCopperNADPHCalciumEthanolaminePGE3TTH2OLeukotrieneE4CysteineLeukotrieneE4CalciumUric acidALA (n-3)XanthineLeukotriene C4Uric acidHomocysteineAscorbic acidS-Adenosylhomocysteine NADPFADiPF2-alphaCobalaminROSHypoxanthineS-Adenosylhomocysteine Leukotriene F4IronLipoxin A45,10-METHYL-THFEPA (n-3)Txnrd1BetaineS-AdenosylmethionineHypoxanthineTHASSeleniumSerinePtgesPGH3PGE2CarnitineCOX2Leukotriene B4SerineZincL-MethionineCystathioneSepx1Methylmalonic acidGpx4H2O2CNLeukotriene C4PGD2BGlutathione disulfideHemeC22:5 (n-6)CysteineIronCOX1NADP2-Ketobutyric acidO2HomocysteineGlutathioneIENicotinamide172015113, 1452


Description

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP176(r30153) with a 58% conversion rate.

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Bibliography

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  1. Vladimir Kery, Loelle Poneleit, Jeffrey D. Meyer, Mark C. Manning, Jan P. Kraus; ''Binding of Pyridoxal 5'-Phosphate to the Heme Protein Human Cystathionine β-Synthase''; Biochemistry 38(9), 1999 DOI Scholia
  2. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC Scholia
  3. Morrow JD, Roberts LJ 2nd.; ''The isoprostanes. Current knowledge and directions for future research.''; Biochem Pharmacol., 1996 PubMed Europe PMC Scholia
  4. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr, 1999 PubMed Europe PMC Scholia
  5. George J, Struthers AD.; ''The role of urate and xanthine oxidase inhibitors in cardiovascular disease.''; Cardiovasc Ther., 2008 PubMed Europe PMC Scholia
  6. Fernandes-Costa F: Metz J.; ''Vitamin B12 binders (transcobalamins) in serum.''; Crit Rev Clin Lab Sci. , 1982 PubMed Europe PMC Scholia
  7. Longhi RC, Fleisher LD, Tallan HH, Gaull GE.; ''Cystathionine beta-synthase deficiency: a qualitative abnormality of the deficient enzyme modified by vitamin B6 therapy.''; Pediatr Res. , 1977 PubMed Europe PMC Scholia
  8. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr. , 1999 PubMed Europe PMC Scholia
  9. https://analysis.ingenuity.com/pa/; ''Prostaglandin and Leukotriene Metabolism''; Ingenuity software
  10. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia
  11. Basu S.; ''Isoprostanes: novel bioactive products of lipid peroxidation.''; Free Radic Res., 2004 PubMed Europe PMC Scholia
  12. Fowler B.; ''Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. ''; Semin Vasc Med, 2005 PubMed Europe PMC Scholia
  13. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.''; Nat Struct Biol. , 2002 PubMed Europe PMC Scholia
  14. Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R; ''A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. ''; Molecular genetics and metabolism, 1999 PubMed Europe PMC Scholia
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  16. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM.; ''Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.''; IUBMB Life., 2008 PubMed Europe PMC Scholia
  17. https://analysis.ingenuity.com/; ''Arachidonic Acid Metabolism''; Ingenuity sofware
  18. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R, Gravel RA.; ''Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. ''; Hum Mol Genet. , 1996 PubMed Europe PMC Scholia
  19. Hall CA; ''Transcobalamins I and II as natural transport proteins of vitamin B12. ''; The Journal of clinical investigation , 1975 PubMed Europe PMC Scholia
  20. Kryukov GV, Kumar RA, Koc A, Sun Z, Gladyshev VN.; ''Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.''; Proc Natl Acad Sci U S A. , 2002 PubMed Europe PMC Scholia
  21. WikiPathways; ''Selenoproteins''; http://www.wikipathways.org/index.php/Pathway:Homo_sapiens:Selenoproteins
  22. http://lpi.oregonstate.edu/infocenter/vitamins/fa/; ''Folic acid''; Linus Pauling Institute
  23. Lu C, Qiu F, Zhou H, Peng Yp, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X.; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett., 2006 PubMed Europe PMC Scholia
  24. https://analysis.ingenuity.com/; ''Prostaglandin and Leukotriene Metabolism''; Ingenuity software
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  26. ''Food and Nutrition Board, Institute of Medicine. Vitamin B6. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline.''; Washington D.C.: National Academies Press, 1998
  27. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone''; Prostaglandins., 1982 PubMed Europe PMC Scholia
  28. Ben van Ommen, Susan Fairweather-Tait, Andreas Freidig, Alwine Kardinaal, Augustin Scalbert, Suzan Wopereis; ''A network biology model of micronutrient related health''; Br J Nutr, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125270view14:50, 31 January 2023LarsgwFix references
125269view14:49, 31 January 2023LarsgwFix references
124807view21:39, 11 December 2022AlexanderPicofixed ontology tag
124806view21:39, 11 December 2022AlexanderPicofixed citations
124777view06:26, 11 December 2022AlexanderPicofixed citations
120917view06:29, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
118150view10:40, 25 May 2021EweitzModified title
114089view07:24, 22 December 2020EgonwRemoved duplicate reference info
114033view15:51, 17 December 2020LaurentConnected lines
106851view13:33, 17 September 2019MaintBotHMDB identifier normalization
101980view20:31, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
101976view20:00, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
85058view10:53, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82696view18:11, 22 October 2015EgonwFixed a typo.
74467view16:12, 24 April 2014EgonwFixed a PubMed ID.
69126view18:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
69056view18:04, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68384view09:42, 4 July 2013EgonwMade the link to Wikipedia machine readable.
68383view09:41, 4 July 2013EgonwFixed the DataNode type of two nodes with gene identifiers.
67254view10:27, 26 June 2013Christine ChichesterOntology Term : 'pathway of folate cycle/metabolism' added !
60224view20:01, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
59041view20:43, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48256view21:44, 17 May 2012KhanspersUpdating PubChem xrefs
48230view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
43782view20:38, 27 July 2011Samuel SklarSpecify description
43781view19:18, 27 July 2011Samuel SklarPeriodical save, work in progress
42731view22:19, 24 April 2011MaintBotfixed blank db refs
42730view22:17, 24 April 2011MaintBotfixed odd db refs
41311view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
34393view22:53, 9 December 2009MaintBotAutomatic update of empty xrefs
33189view18:05, 5 November 2009KhanspersModified categories
32300view13:16, 15 August 2009MaintBotFixed text labels
31873view12:39, 14 August 2009MaintBotFixed group labels
31329view20:21, 13 August 2009MaintBotFixed text labels
30907view00:26, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-MethylnicotinamideMetaboliteHMDB00699 (HMDB)
1-methylnicotinamideMetaboliteHMDB00699 (HMDB)
15-HETEMetaboliteHMDB02218 (HMDB)
2-Ketobutyric acidMetaboliteHMDB00005 (HMDB)
5,10-METHYL-THFMetaboliteHMDB01396 (HMDB)
5-HPETEMetaboliteHMDB01193 (HMDB)
AA (n-6)MetaboliteHMDB01043 (HMDB)
ALA (n-3)MetaboliteHMDB01388 (HMDB)
Adipic acid MetaboliteHMDB00448 (HMDB)
Adipic acidMetaboliteHMDB00448 (HMDB)
Alox5Protein11689 (Entrez Gene)
Ascorbic acidMetaboliteHMDB00044 (HMDB)
BGeneProduct
BetaineMetaboliteHMDB00043 (HMDB)
C22:5 (n-6)MetaboliteHMDB01976 (HMDB)
CNGeneProduct
COX1Protein
COX2Protein
CalciumMetaboliteHMDB00464 (HMDB)
CarnitineMetaboliteHMDB00062 (HMDB)
CatProtein12359 (Entrez Gene)
CbsProtein12411 (Entrez Gene)
CholineMetaboliteHMDB00097 (HMDB)
CobalaminMetaboliteHMDB02174 (HMDB)
CopperMetaboliteHMDB00657 (HMDB)
CystathioneMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
DHA (n-3)MetaboliteHMDB02183 (HMDB)
EPA (n-3)MetaboliteHMDB01999 (HMDB)
EndoperoxidaseProtein
EthanolamineMetaboliteHMDB00149 (HMDB)
F2-IsoprostaneMetaboliteHMDB04659 (HMDB)
FADMetabolite703 (PubChem)
FMN1Metabolite342184 (Entrez Gene)
FOLIC ACIDMetaboliteHMDB00121 (HMDB)
Fads2Protein56473 (Entrez Gene)
Glutathione disulfideMetabolite65359 (PubChem) Type your comment here
GlutathioneMetaboliteHMDB00125 (HMDB)
GlycineMetaboliteHMDB00123 (HMDB)
Gpx1Protein14775 (Entrez Gene)
Gpx2Protein14776 (Entrez Gene)
Gpx3Protein14778 (Entrez Gene)
Gpx4Protein625249 (Entrez Gene)
Gpx6Protein75512 (Entrez Gene)
GsrProteinENSMUSG00000031584 (Ensembl Mouse) Type your comment here
H2O2MetaboliteHMDB03125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetabolite
HomocysteineMetaboliteHMDB00742 (HMDB)
HypoxanthineMetaboliteHMDB00157 (HMDB)
IEGeneProduct
IronMetaboliteHMDB00692 (HMDB)
KmoProtein98256 (Entrez Gene)
L-Glutamic acidMetaboliteHMDB00148 (HMDB)
L-MethionineMetaboliteHMDB00696 (HMDB)
LA (n-6)MetaboliteHMDB00673 (HMDB)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene F4Metabolite
LeukotrieneE4MetaboliteHMDB02200 (HMDB)
Lipoic acidMetaboliteHMDB01451 (HMDB)
Lipoxin A4MetaboliteHMDB04385 (HMDB)
Lipoxin B4MetaboliteHMDB05082 (HMDB)
ManganeseMetaboliteHMDB01333 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
Methylmalonic acid MetaboliteHMDB00202 (HMDB)
Methylmalonic acidMetaboliteHMDB00202 (HMDB)
MthfrProtein17769 (Entrez Gene)
MtrProtein238505 (Entrez Gene)
NADPHMetaboliteHMDB00221 (HMDB)
NADPMetaboliteHMDB00217 (HMDB)
NiacinMetaboliteHMDB01406 (HMDB)
NicotinamideMetabolite7847104 (PubChem)
O2MetaboliteHMDB01377 (HMDB)
PGD2MetaboliteHMDB01403 (HMDB)
PGE2Metabolite
PGE3MetaboliteHMDB02664 (HMDB)
PGF2aMetaboliteHMDB01139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB03235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB01381 (HMDB)
PGH3Metabolite
PGI2Metabolite
PGI2MetaboliteHMDB01335 (HMDB)
PnpoProtein103711 (Entrez Gene)
PtgdsProtein19215 (Entrez Gene)
PtgesProtein64292 (Entrez Gene)
PtgisProtein19223 (Entrez Gene)
Pyrodoxal-5'-phosphateMetaboliteHMDB01491 (HMDB)
ROSMetabolitehttp://en.wikipedia.org/wiki/Reactive_oxygen_species
RiboflavinMetaboliteHMDB00244 (HMDB) Type your comment here
S-Adenosylhomocysteine MetaboliteHMDB00939 (HMDB)
S-Adenosylmethionine MetaboliteHMDB01185 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
SODProtein
SeleniumMetaboliteHMDB01349 (HMDB)
SelkProtein80795 (Entrez Gene)
Sepw1Protein20364 (Entrez Gene)
Sepx1Protein27361 (Entrez Gene)
SerineMetaboliteHMDB00187 (HMDB)
TGeneProduct
THASProtein
TRXR 3Protein
TTGeneProduct
ThioredoxinMetabolite7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
TranscobalaminProtein
Tromboxane A2MetaboliteHMDB01452 (HMDB)
TryptophanMetaboliteHMDB00929 (HMDB)
Txnrd1Protein50493 (Entrez Gene)
Txnrd2Protein26462 (Entrez Gene)
Uric acidMetaboliteHMDB00289 (HMDB)
Vitamin B12MetaboliteHMDB00607 (HMDB)
XanthineMetaboliteHMDB00292 (HMDB)
XdhProtein22436 (Entrez Gene)
ZincMetaboliteHMDB01303 (HMDB)
a TocopherolMetaboliteHMDB01893 (HMDB)
a-tocopherolMetaboliteHMDB01893 (HMDB)
d4 desaturaseProtein
d5 desaturaseProtein
iPF2-alphaMetaboliteHMDB04659 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1273"