EPO receptor signaling (Danio rerio)

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eporjak2bsrcepor1, 2PBox-1PPPPPPPPPPY343Y479Box-2DNACell membraneY343Y460PPBox-2Box-1PY431EPOzgc:77033EPOzgc:172250mapk1LOC792354map2k1stat1amapk3grb2LOC563639LOC555840socs1STAT5BcishSTAT5Astat3stat3stat1aCD45ptpruPPPgrb2raf1SOS1IRS2jak2bLOC559281rasa1raf1SOS1rasa1


Description

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia This pathway is based on ScienceSlides.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP581(r22574) with a 77% conversion rate.

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Ontology Terms

 

Bibliography

  1. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed Europe PMC Scholia
  2. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116862view10:56, 14 May 2021EweitzModified title
68669view05:27, 6 July 2013MaintBotUpdated to 2013 gpml schema
67198view10:19, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
40842view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35099view13:04, 11 February 2010Thomasadded literature
34225view21:36, 9 December 2009MaintBotAutomatic update of empty xrefs
31925view12:53, 14 August 2009MaintBotFixed group labels
31046view01:20, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CD45GeneProduct
EPOGeneProduct100004455 (Entrez Gene)
IRS2GeneProduct
LOC555840GeneProduct555840 (Entrez Gene)
LOC559281GeneProduct559281 (Entrez Gene)
LOC563639GeneProduct563639 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
SOS1GeneProduct
STAT5AGeneProduct
STAT5BGeneProduct
cishGeneProduct767678 (Entrez Gene)
eporGeneProduct751109 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
jak2bGeneProduct30298 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
ptpruGeneProduct335096 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
rasa1GeneProduct100002155 (Entrez Gene)
socs1GeneProduct445073 (Entrez Gene)
srcGeneProduct325084 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)
zgc:77033GeneProduct406598 (Entrez Gene)

Annotated Interactions

No annotated interactions
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